protein 2,155 words KG: NPTX1 2026-03-28
kind:proteinsection:proteinsstate:published
Contents

NPTX1 Protein

🔬 Protein Info
Gene SymbolNPTX1
AliasesNeuronal Pentraxin 1
FunctionNeuronal Pentraxin 1 (NPTX1) is a member of the pentraxin family of proteins, which are characterized by their ability to bind to phosphatidylserine and apoptotic cells.
Subcellular Localization</strong></td><td>Extracellular, synaptic vesicles, secreted</td></tr>
Molecular Weight47 kDa
Amino Acids430 aa
Pathwaysoxidative stress response
Ensembl IDENSG00000143157
GeneCardsNPTX1
Human Protein AtlasNPTX1
Associated DiseasesInflammation, Neuroinflammation
InteractionsSERPINA3, CTSB, CTSD, PDGFRB, SYNAPSE, CHI3L1
KG Connections111 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (14)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Key Papers (1)

Randomized control trial of evaluation of Clemastine effects on visual
Clinical neurology and neurosu 2020

See Also (11)

Alzheimer Indonesia
institution · KG edge: biomarker_for
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: biomarker_for
IL4 Gene
gene · KG edge: biomarker_for
FGF2 — Fibroblast Growth Factor 2
gene · KG edge: biomarker_for
CTSS — Cathepsin S
gene · KG edge: inhibits

Knowledge Graph (12 edges)

NPTX1 associated_with CHIT1
NPTX1 biomarker_for MDH1
NPTX1 associated_with PDGFRB
NPTX1 biomarker_for SQSTM1
NPTX1 biomarker_for BDNF
NPTX1 biomarker_for APOE
NPTX1 biomarker_for NEFL
NPTX1 associated_with CHI3L1
NPTX1 associated_with VEGFA
NPTX1 biomarker_for GFAP