protein 831 words KG: SYNJ1 2026-03-14
kind:proteinsection:proteinsstate:published
Contents

SYNJ1 Protein

🔬 Protein Info
Gene SymbolSYNJ1
Chromosome21q22.11
Protein TypePhosphatase
FunctionSYNJ1 is crucial for synaptic vesicle cycling
Subcellular Localization</td><td>Presynaptic terminal, endocytic zone</td></tr>
Molecular Weight165 kDa
Amino Acids428 aa
Exons31
PathwaysEndosomal Sorting
UniProt IDSYNJ1
GeneCardsSYNJ1
Human Protein AtlasSYNJ1
Associated DiseasesAls, Cancer, Ms, Parkinson
InteractionsVPS35, VPS13C, ATP13A2, DNAJC6, FBXO7, PINK1
KG Connections79 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (3)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (14)

LRRK2 G2019S Transgenic Mouse Model
model · KG edge: associated_with
Lysosome Dysfunction in Neurodegeneration
mechanism · KG edge: therapeutic_target
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: therapeutic_target
MACF1 — Microtubule-actin crosslinking factor 1
gene · KG edge: associated_with
GAK Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

SYNJ1 associated_with DNAJC6
SYNJ1 associated_with PARK2
SYNJ1 associated_with VPS35
SYNJ1 associated_with PRKN
SYNJ1 interacts_with VPS35
SYNJ1 regulates Endosomal Sorting
SYNJ1 modulates Dopamine Release
SYNJ1 interacts_with VPS13C
SYNJ1 expressed_in VPS13C
SYNJ1 associated_with Parkinson