protein 1,399 words KG: TUBB3 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

TUBB3 Protein

🔬 Protein Info
Gene SymbolTUBB3
Full NameTUBB3 (βIII-Tubulin)
Chromosome16q24.3
Protein FamilyTubulin family
Protein TypeStructural Protein
Target ClassStructural Protein
FunctionTUBB3 performs essential neuronal functions:
Mechanism of ActionSmall molecule stabilizers of microtubule structure or assembly
DruggabilityMedium (0.49)
Clinical StageApproved
Molecular Weight50 kDa
Amino Acids450 aa
PathwaysAkt, Autophagy, Cell Cycle, Pi3K, Proteasome
UniProt IDQ9YH59
Ensembl IDENSG00000198363
GeneCardsTUBB3
Human Protein AtlasTUBB3
Associated DiseasesAlzheimer, Alzheimer's disease, Anoikis Resistance, Bone Metastasis, Huntington, Huntington's disease
Known Drugs/Compoundsrapamycin
InteractionsSRC, ATG7, JUN, ACTB, NGF, VEGFA
SciDEX TargetView Target Profile (8 clinical trials)
SciDEX HypothesesQuantum Coherence Disruption in Cellular Communica
KG Connections424 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (20)

Quantum Coherence Disruption in Cellular Communication
Score: 0.34
Circadian Clock-Autophagy Synchronization
Score: 0.55
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.50

Related Analyses (8)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (7)

Alzheimer Indonesia
institution · KG edge: activates
ATG7 Gene
gene · KG edge: activates
ATG14 Gene
gene · KG edge: activates
ar
gene · KG edge: activates
ACTB Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

TUBB3 associated_with neurodegeneration
TUBB3 co_discussed CLOCK
TUBB3 co_discussed PLIN2
TUBB3 co_discussed PIEZO1
TUBB3 co_discussed GABRA1
TUBB3 co_discussed G3BP1
TUBB3 inhibits SRC
TUBB3 associated_with STK11
TUBB3 associated_with VIM
TUBB3 regulates BECN1