| Gene Symbol | SLC1A1 |
| Protein Type | Transporter |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | pyramidal neurons and medium spiny neurons - Glia: Low expression in astrocytes compared to EAAT1 (GL |
| Molecular Weight | 57 kDa |
| GeneCards | SLC1A1 |
| Human Protein Atlas | SLC1A1 |
| High-affinity glutamate uptake | Km for glutamate approximately 10-20 μM |
| Sodium coupling | Transport is driven by the inward Na+ gradient |
| Stoichiometry | 3 Na+ + 1 glutamate + 1 H+ in / 1 K+ out |
| Electrogenic | Net positive charge influx during transport |
| Cysteine transport | EAAT3 also transports cystine, supporting glutathione synthesis |
| Brain | Highest expression in hippocampus (CA1 > CA3 > dentate gyrus), cerebral cortex (layers II-III), basal ganglia (striatum > globus pallidus), and olfactory bulb |
| Neuronal subtypes | Predominantly expressed in pyramidal neurons and medium spiny neurons |
| Glia | Low expression in astrocytes compared to EAAT1 (GLAST) and EAAT2 (GLT-1) |
| Associated Diseases | Alzheimer, Autism, Bipolar, Cancer, Inflammation, Parkinson |
| Interactions | CACNA1B, CACNA1H, DRD1, DRD2, GABRA1, GABRB2 |
| KG Connections | 61 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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