gene 1,738 words KG: GRM5 2026-03-27
kind:genesection:genesstate:published
Contents

GRM5 Gene - Metabotropic Glutamate Receptor 5

🧬 Gene Info
Gene SymbolGRM5
AliasesGLUR5, mGlu5, GPRC1E
Chromosome11q14.2
Protein FamilyClass C GPCR, metabotropic glutamate receptors
Protein TypeReceptor
FunctionmGluR5 mediates modulatory glutamate signaling
Subcellular LocalizationPlasma membrane, Dendritic spines
Molecular Weight132 kDa
Exons10
PathwaysMAPK
UniProt IDP41594
NCBI Gene ID2915
GeneCardsGRM5
Human Protein AtlasGRM5
ProteinmGluR5 protein
Associated DiseasesAlzheimer, Autism, Bipolar, Cancer, Inflammation, Ms
InteractionsFGF13, CDK5R2, SLC17A7, GRIK4, SLC6A2, SLC1A1
KG Connections130 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.47
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (6)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (10)

Alzheimer Indonesia
institution · KG edge: associated_with
GABRA1 Gene
gene · KG edge: associated_with
FGF13 — Fibroblast Growth Factor 13
gene · KG edge: associated_with
DRD2 Gene
gene · KG edge: associated_with
DRD1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

GRM5 associated_with GABARAP
GRM5 associated_with GABRB1
GRM5 therapeutic_target SCN8A
GRM5 therapeutic_target STAT1
GRM5 therapeutic_target FGF13
GRM5 therapeutic_target SCN2B
GRM5 therapeutic_target CDK5R2
GRM5 therapeutic_target ISG15
GRM5 associated_with HTR2A
GRM5 associated_with GABRA1