therapeutic 1,104 words KG: ent-gene-9f063e98 2026-03-29
kind:therapeuticsection:therapeuticsstate:publishedtopic:parkinsonsdisease:parkinsons-diseasemechanism:lrnk2-pathway
Contents

LRRK2-Targeting Therapies

🔬 Protein Info
Gene SymbolLRRK2
Full NameTargeting Therapies
Chromosome12q12
Protein TypeProtein
Amino Acids2527 aa
PathwaysMAPK
UniProt IDSearch UniProt
GeneCardsLRRK2
Human Protein AtlasLRRK2
BIIB122 (DNL151)Biogen/Denali
PF-06685360Pfizer
PBT434Prima BioMed
GZ-161Pharma partners
LL-010Lexicon
MRC-4869Medical Research Council
Associated DiseasesALS, Aging, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/CompoundsRAPAMYCIN, levodopa, Cigarette Smoking, MLi-2, PF-06447475, Environmental Toxicants
InteractionsATG16L1, RB1CC1, GABARAP, ERN1, STAT3, IFNG
KG Connections2480 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (25)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.39
Lysosomal Positioning Dynamics Modulation
Score: 0.43
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59

Related Analyses (13)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

Related Experiments (28)

AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Thera
validation · proposed · Score: 0.40
AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40
AAV Serotype Comparison for LRRK2 Knockdown in PD
validation · proposed · Score: 0.40
Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40
Computational Modeling of Alpha-Synuclein Propagation in PD
validation · proposed · Score: 0.40

See Also (15)

Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 3 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 3 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 3 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 3 hypotheses
Vagus Nerve Pathway in Neurodegeneration
mechanism · Pages share 3 hypotheses

Knowledge Graph (2 edges)

ent-gene-9f063e98 data_in benchmark_ot_ad_answer_key:LRRK2
benchmark_ot_ad_answer_key:LRRK2 data_in ent-gene-9f063e98