protein 722 words KG: XBP1
Contents

XBP1 - X-Box Binding Protein 1

🔬 Protein Info
Gene SymbolXBP1
Full NameX-Box Binding Protein 1
AliasesPage for XBP1
Chromosome22q12.1
Protein TypeTranscription Factor
FunctionER Expansion and Biogenesis: Increases ER membrane synthesis and volume
Primary ExpressionBrain, Liver, Pancreas, Immune cells
Molecular Weight29 kDa
Amino Acids261 aa
PathwaysAutophagy, Er Stress, Glycolysis, Mitophagy, Unfolded Protein Response
UniProt IDP17861
NCBI Gene ID7499
Ensembl IDENSG00000143419
GeneCardsXBP1
Human Protein AtlasXBP1
Associated Diseasesoligodendrocyte demyelination, Tumor
InteractionsAKT, AND, APOE4, ATF3, ATF4, ATF6
KG Connections264 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (1)

ER-Associated Degradation (ERAD) Cross-Activation
Score: 0.55

Knowledge Graph (12 edges)

CXCL2 therapeutic_target XBP1
IL6 therapeutic_target XBP1
ATF4 activates XBP1
PPP1R15A activates XBP1
IL12B therapeutic_target XBP1
XBP1 therapeutic_target CXCL1
XBP1 activates DDIT3
XBP1 therapeutic_target CLDN5
XBP1 activates HSPA5
XBP1 therapeutic_target OCLN

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