🧫
Why Does Amyloid Removal Only Slow Decline 27%? — Mechanistic investigation
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-wiki-experiments-amyloid-
🧫 Experiment Protocol
Clinical
Metadata
| experiment_type | clinical |
| source | {'type': 'manual', 'source_name': 'wiki', 'extraction_date': '2026-04-16T01:00:16.901843Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['CENTIRON'], 'diseases': ["Alzheimer's Disease"]} |
| model_system | human |
| summary | # Why Does Amyloid Removal Only Slow Decline 27%? — Mechanistic investigation ## Background and Rationale The amyloid cascade hypothesis has dominated Alzheimer's disease (AD) research for over three |
| replication_status | single_study |
| methodology_notes | Phase 1 (Months 0-3): Recruit 240 mild cognitive impairment/early AD patients, stratified by APOE4 status and CSF p-tau181 levels. Collect baseline measurements including 18F-flortaucipir PET, 11C-PIB |
| primary_outcome | Validate Why Does Amyloid Removal Only Slow Decline 27%? — Mechanistic investigation |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.901848'} |
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