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Amyloid-Beta (Aβ)

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slug	proteins-amyloid-beta
entity_type	protein
kg_node_id	AMYLOIDBETA

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related📖AMYLOIDBETA100%

mentions🧪SASP-Driven Aquaporin-4 Dysregulation70%

mentions🧪Aquaporin-4 Polarization Rescue70%

mentions🧪Circadian-Synchronized LRP1 Pathway Activation70%

mentions🧪Synthetic Biology BBB Endothelial Cell Reprogramming70%

mentions🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides70%

related🧫Animal Model Comparison for Neurodegenerative Disease Therap70%

related🧫Endocannabinoid System Dysfunction Validation in Parkinson&#70%

related🧫Glymphatic-Circadian Axis Enhancement Therapy for Parkinson&70%

related🧫Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag70%

related🧫Neural Oscillation Dysfunction Validation in Parkinson'70%

related🧫Oligodendrocyte-Myelin Dysfunction Validation in Parkinson&#70%

related🧫Proteasome-Ubiquitin System Dysfunction Validation in Parkin70%

related🧫Protein Aggregation Kinetic Validation Results70%

related🧫Purinergic Signaling Dysfunction Validation in Parkinson70%

related🧫Regulated Necrosis Validation Study in Parkinson's Dise70%

related🧫Stress Granule Dysfunction Validation in Parkinson's Di70%

related🧫Experiment Validation: In vitro ThT Assay70%

related🧫Animal Model Comparison for Neurodegenerative Disease Therap70%

related🧫Endocannabinoid System Dysfunction Validation in Parkinson&#70%

related🧫Glymphatic-Circadian Axis Enhancement Therapy for Parkinson&70%

related🧫Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag70%

related🧫Neural Oscillation Dysfunction Validation in Parkinson'70%

related🧫Oligodendrocyte-Myelin Dysfunction Validation in Parkinson&#70%

related🧫Proteasome-Ubiquitin System Dysfunction Validation in Parkin70%

related🧫Protein Aggregation Kinetic Validation Results70%

related🧫Purinergic Signaling Dysfunction Validation in Parkinson70%

related🧫Regulated Necrosis Validation Study in Parkinson's Dise70%

related🧫Stress Granule Dysfunction Validation in Parkinson's Di70%

related🧫Experiment Validation: In vitro ThT Assay70%

mentions🧪Palmitoylation-Targeted BACE1 Trafficking Disruptors65%

mentions🧪Autophagosome Maturation Checkpoint Control65%

mentions🧪Glymphatic System-Enhanced Antibody Clearance Reversal65%

mentions🧪Cross-Seeding Prevention Strategy65%

related🧪SASP-Driven Aquaporin-4 Dysregulation63%

related🧪Aquaporin-4 Polarization Rescue63%

related🧪Circadian-Synchronized LRP1 Pathway Activation63%

related🧪Synthetic Biology BBB Endothelial Cell Reprogramming63%

related🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides63%

mentions🧫Generation of Aβ-specific Tregs using CRISPR-Cas960%

mentions🧫AD Combination Therapy Trial: Anti-Aβ + Anti-Tau60%

mentions🧫Why Does Amyloid Removal Only Slow Decline 27%? — Mechanisti60%

mentions🧫Neural Stem Cell Therapy for Alzheimer's Disease60%

see_also📖Neurodegeneration60%

related🧪Palmitoylation-Targeted BACE1 Trafficking Disruptors58%

related🧪Autophagosome Maturation Checkpoint Control58%

related🧪Glymphatic System-Enhanced Antibody Clearance Reversal58%

related🧪Cross-Seeding Prevention Strategy58%

see_also📖Cell-Free DNA Biomarkers in Neurodegeneration55%

see_also📖Exosomal Biomarkers in Neurodegeneration55%

see_also📖Exosomal miR-155 in Neurodegeneration55%

see_also📖IL-6 (Interleukin-6) in Neurodegeneration55%

see_also📖Liquid Biopsy in Neurodegeneration55%

see_also📖Metabolomic Biomarkers in Neurodegeneration55%

see_also📖Neuroimaging Biomarkers for Neurodegeneration55%

see_also📖Synaptic Biomarkers in Neurodegeneration55%

see_also📖BEACoN Study - Biomarker Exploration in Aging, Cognition and55%

see_also📖Olfactory Mucosa, Blood and Urine for Identification of Earl55%

see_also📖Swedish BioFINDER 2 Study: Biomarkers and Neurodegeneration 55%

see_also📖Beta-Propeller Protein-Associated Neurodegeneration (BPAN)55%

see_also📖China Neurodegeneration Epidemiology55%

see_also📖DALY Methodology — Neurodegeneration55%

see_also📖Disease Progression & Staging in Neurodegeneration55%

see_also📖Economic Burden — Neurodegeneration55%

see_also📖European Neurodegeneration Epidemiology55%

see_also📖Familial vs Sporadic Neurodegeneration Comparison55%

see_also📖Global Neurodegeneration Epidemiology55%

see_also📖India Neurodegeneration Epidemiology55%

see_also📖Japan Neurodegeneration Epidemiology55%

see_also📖Manganese-Related Neurodegeneration (Manganism)55%

see_also📖mitochondrial-dysfunction-neurodegeneration-comparison55%

see_also📖Mitochondrial Diseases and Neurodegeneration Comparison Matr55%

see_also📖Mitochondrial Membrane Protein-Associated Neurodegeneration 55%

see_also📖Neurodegeneration with Brain Iron Accumulation (NBIA)55%

see_also📖Potential Impact Measures — Neurodegeneration55%

see_also📖Pantothenate Kinase-Associated Neurodegeneration (PKAN)55%

see_also📖PLA2G6-Associated Neurodegeneration (PLAN)55%

see_also📖Sleep Disorders in Neurodegeneration55%

see_also📖US Neurodegeneration Epidemiology55%

see_also📖Extracellular Vesicle and Tunneling Nanotube-Mediated Spread55%

see_also📖acetylcholine-signaling-neurodegeneration55%

see_also📖Advanced Glycation End Products in Neurodegeneration55%

see_also📖Advanced In Vitro Models for Neurodegeneration — Organoids, 55%

see_also📖Amylin Signaling in Neurodegeneration55%

see_also📖Antibody Therapy in Neurodegeneration55%

see_also📖Antisense Oligonucleotide (ASO) Therapy in Neurodegeneration55%

see_also📖Autosis Pathway in Neurodegeneration55%

see_also📖Axon Guidance Pathways in Neurodegeneration55%

see_also📖Basal Ganglia Circuit Dysfunction in Neurodegeneration55%

see_also📖becn1-autophagy-initiation-neurodegeneration-causal-chain55%

see_also📖CaMKII Signaling Pathway in Neurodegeneration55%

see_also📖Carbonic Anhydrase Modulator Therapy in Neurodegeneration55%

see_also📖Cerebral Amyloid Angiopathy in Neurodegeneration55%

see_also📖Cerebral Amyloid Angiopathy Pathway in Neurodegeneration55%

see_also📖Cholinergic System Dysfunction in Neurodegeneration55%

see_also📖Chrononutrition and Time-Restricted Eating in Neurodegenerat55%

see_also📖Neural Circuits in Neurodegeneration55%

see_also📖Cognitive Reserve and Resilience in Neurodegeneration55%

see_also📖Computational Disease Models for Neurodegeneration55%

see_also📖Convergent Pathways in Neurodegeneration55%

see_also📖Copper Homeostasis in Neurodegeneration55%

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see_also📖Diffusion MRI (DTI) in Neurodegeneration55%

see_also📖Digital Phenotyping in Neurodegeneration55%

see_also📖Down Syndrome Neurodegeneration Pathway55%

see_also📖Dystrophic Neurites in Neurodegeneration55%

see_also📖Endocannabinoid System in Neurodegeneration55%

see_also📖Endosomal-Lysosomal Pathway in Neurodegeneration55%

see_also📖Endosomal Sorting Defects in Neurodegeneration55%

see_also📖Endothelin Signaling Pathway in Neurodegeneration55%

see_also📖epigenetics-neurodegeneration55%

see_also📖ESCRT-III Inhibition by Alpha-Synuclein in Neurodegeneration55%

see_also📖FA2H-Associated Neurodegeneration Pathway55%

see_also📖Farnesoid X Receptor (FXR) Signaling in Neurodegeneration55%

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see_also📖GDNF Signaling Pathway in Neurodegeneration55%

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see_also📖Glucocorticoid Signaling Pathway in Neurodegeneration55%

see_also📖Glycosylation in Neurodegeneration55%

see_also📖gp130/IL-6 Family Cytokine Signaling in Neurodegeneration55%

see_also📖Hippocampal Neurogenesis in Neurodegeneration55%

see_also📖Histone Modification Pathways in Neurodegeneration55%

see_also📖HMGB1 Signaling in Neurodegeneration55%

see_also📖Homocysteine Neurotoxicity and Neurodegeneration55%

see_also📖IGF-1 Signaling Pathway in Neurodegeneration55%

see_also📖IL-1 Signaling Pathway in Neurodegeneration55%

see_also📖Integrated Stress Response in Neurodegeneration55%

see_also📖interleukin-6-signaling-neurodegeneration55%

see_also📖Intrinsic Apoptosis Pathway in Neurodegeneration55%

see_also📖Ion Channel Dysfunction in Neurodegeneration: Cross-Disease 55%

see_also📖Kidney-Brain Neurodegeneration Axis55%

see_also📖Lipid Dysregulation in Neurodegeneration55%

see_also📖Lipid Metabolism Dysregulation in Neurodegeneration55%

see_also📖Lysosomal Calcium Dysregulation in Neurodegeneration55%

see_also📖Magnetic Resonance Spectroscopy in Neurodegeneration55%

see_also📖Metal Homeostasis Dysregulation in Neurodegeneration55%

see_also📖Metal Homeostasis in Neurodegeneration55%

see_also📖Microglial Priming Pathway in Neurodegeneration55%

see_also📖MicroRNA Dysfunction in Neurodegeneration55%

see_also📖Mineralocorticoid Receptor Signaling in Neurodegeneration55%

see_also📖Mitochondrial Dynamics Pathway in Neurodegeneration55%

see_also📖Mitochondrial Fusion in Neurodegeneration55%

see_also📖Molecular Chaperones in Neurodegeneration55%

see_also📖mTOR Signaling in Neurodegeneration55%

see_also📖mTOR Signaling Pathway in Neurodegeneration55%

see_also📖Neural Circuit Disruption in Neurodegeneration55%

see_also📖Neurexin/Neuroligin Synaptic Adhesion Modulator Therapy in N55%

see_also📖Neurofilament Light Chain (NfL) Mechanism in Neurodegenerati55%

see_also📖Neuronal Hyperexcitability in Neurodegeneration55%

see_also📖Neuropil Threads in Neurodegeneration55%

see_also📖Neurotensin Signaling in Neurodegeneration55%

see_also📖Neurovascular Unit Dysfunction in Neurodegeneration55%

see_also📖NF-kB Signaling Pathway in Neurodegeneration55%

see_also📖Nitric Oxide Signaling in Neurodegeneration55%

see_also📖Noradrenergic Signaling Pathway in Neurodegeneration55%

see_also📖Neuropeptide Y Signaling in Neurodegeneration55%

see_also📖NRF2 Signaling Pathway in Neurodegeneration55%

see_also📖Nuclear Pore Complex Dysfunction in Neurodegeneration55%

see_also📖Orexin Signaling in Neurodegeneration55%

see_also📖OSK Reprogramming and Yamanaka Factors in Neurodegeneration55%

see_also📖P-Body (Processing Body) Pathway in Neurodegeneration55%

see_also📖Paranodal Dysfunction in Neurodegeneration55%

see_also📖Paraptosis in Neurodegeneration55%

see_also📖Parthanatos in Neurodegeneration55%

see_also📖Pericyte Loss in Neurodegeneration55%

see_also📖Peripheral Immune-Brain Crosstalk in Neurodegeneration55%

see_also📖PKR Pathway in Neurodegeneration55%

see_also📖PPAR Signaling Pathway in Neurodegeneration55%

see_also📖Prion Diseases in Neurodegeneration55%

see_also📖Prion-Like Spread in Neurodegeneration55%

see_also📖Prion Protein Metabolism in Neurodegeneration55%

see_also📖Progesterone Signaling Pathway in Neurodegeneration55%

see_also📖Prognostic Biomarkers in Neurodegeneration55%

see_also📖Protein Aggregation Comparison in Neurodegeneration55%

see_also📖Protein Aggregation Seeds in Neurodegeneration55%

see_also📖Protein O-GlcNAcylation Pathway in Neurodegeneration55%

see_also📖Cortical Involvement and Neurodegeneration in Progressive Su55%

see_also📖Purinergic Signaling in Neurodegeneration55%

see_also📖Quantum Biology and Coherent Energy Transfer in Neurodegener55%

see_also📖R-Loop Stress in Neurodegeneration55%

see_also📖RAN Translation in Neurodegeneration55%

see_also📖Retinal Degeneration Pathway in Neurodegeneration55%

see_also📖Ribosome Dysfunction in Neurodegeneration55%

see_also📖RNA Splicing in Neurodegeneration55%

see_also📖RNA-Targeted Therapies in Neurodegeneration55%

see_also📖Ribonuclease κ and Circular RNAs: A New Mechanism of Aging a55%

see_also📖S100 Protein Signaling Pathway in Neurodegeneration55%

see_also📖Senescent Cell Clearance in Neurodegeneration55%

see_also📖Serotonergic Dysfunction in Neurodegeneration55%

see_also📖Sex Differences in Neurodegeneration55%

see_also📖Short Chain Fatty Acids in Neurodegeneration55%

see_also📖Sigma-1 Receptor Signaling in Neurodegeneration55%

see_also📖Sirtuin-Mitochondrial Biogenesis Axis in Neurodegeneration55%

see_also📖Sleep Dysfunction in Neurodegeneration55%

see_also📖SUMOylation in Neurodegeneration55%

see_also📖synaptic-vesicle-cycling-neurodegeneration55%

see_also📖Synthetic Lethality and PARP Inhibition in Neurodegeneration55%

see_also📖T-Cell Dysfunction in Neurodegeneration55%

see_also📖Tertiary Lymphoid Organs in Neurodegeneration55%

see_also📖Therapeutic Targets in Neurodegeneration55%

see_also📖Transdiagnostic Proteomic Changes in Neurodegeneration55%

see_also📖ubiquitin-proteasome-dysfunction-neurodegeneration55%

see_also📖Ubiquitin-Proteasome System Dysfunction in Neurodegeneration55%

see_also📖Vagus Nerve Pathway in Neurodegeneration55%

see_also📖VEGF Signaling and Cerebral Angiogenesis in Neurodegeneratio55%

see_also📖vip-vasoactive-intestinal-peptide-signaling-neurodegeneratio55%

see_also📖WNK1-Bilirubin Signaling in Neuroinflammation and Neurodegen55%

see_also📖Wnt/β-Catenin Signaling Pathway in Neurodegeneration55%

related🧫Generation of Aβ-specific Tregs using CRISPR-Cas954%

related🧫AD Combination Therapy Trial: Anti-Aβ + Anti-Tau54%

related🧫Why Does Amyloid Removal Only Slow Decline 27%? — Mechanisti54%

related🧫Neural Stem Cell Therapy for Alzheimer's Disease54%

mentions🧪LRP1-Dependent Tau Uptake Disruption50%

mentions🧪Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m50%

related🔬What are the mechanisms underlying blood-brain barrier trans50%

related🔬What are the mechanisms underlying autophagy-lysosome pathwa50%

related🔬Investigate how lipid raft composition (cholesterol metaboli50%

related🔬What are the mechanisms underlying rna binding protein dysre50%

related🔬What are the mechanisms underlying mitochondrial transfer be50%

related🧪Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna50%

related🧪Circadian Rhythm Entrainment of Reactive Astrocytes50%

related🧪Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A50%

related🧪Temporal Decoupling via Circadian Clock Reset50%

related🧪Circadian Clock-Autophagy Synchronization50%

related🧪Flotillin-1 Stabilization Compounds50%

related🧪GFAP-Positive Reactive Astrocyte Subtype Delineation50%

related🧪APOE-Dependent Autophagy Restoration50%

related🧪Nutrient-Sensing Epigenetic Circuit Reactivation50%

related🧪The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction50%

related🧪TFEB-PGC1α Mitochondrial-Lysosomal Decoupling50%

related🧪Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam50%

related🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer50%

related🧪APOE Isoform Conversion Therapy50%

related🧪APOE4 Allosteric Rescue via Small Molecule Chaperones50%

related🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction50%

related🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%

related🧪APOE4-Selective Lipid Nanoemulsion Therapy50%

related🧪Competitive APOE4 Domain Stabilization Peptides50%

related🧪APOE Isoform Expression Across Glial Subtypes50%

related🧪CYP46A1 Overexpression Gene Therapy50%

related🧪Pericyte Contractility Reset via Selective PDGFR-β Agonism50%

related🧪Magnetosonic-Triggered Transferrin Receptor Clustering50%

related🧪TREM2 Conformational Stabilizers for Synaptic Discrimination50%

related🧪APOE-TREM2 Interaction Modulation50%

related🧪TREM2-Mediated Selective Aggregate Clearance Pathway50%

related🧪TREM2-Dependent Microglial Senescence Transition50%

related🧪TREM2-mediated microglial tau clearance enhancement50%

related🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%

related🧪SASP-Driven Aquaporin-4 Dysregulation50%

related🧪Aquaporin-4 Polarization Rescue50%

related🧪HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor50%

related🧪Lysosomal Positioning Dynamics Modulation50%

related🧪Trans-Synaptic Adhesion Molecule Modulation50%

related🧪Selective HDAC3 Inhibition with Cognitive Enhancement50%

related🧪HDAC3-Selective Inhibition for Clock Reset50%

related🔬What are the mechanisms underlying blood-brain barrier trans50%

related🔬What are the mechanisms underlying autophagy-lysosome pathwa50%

related🔬Investigate how lipid raft composition (cholesterol metaboli50%

related🔬What are the mechanisms underlying rna binding protein dysre50%

related🔬What are the mechanisms underlying mitochondrial transfer be50%

related🔬Analyze circuit-level changes in neurodegeneration using All50%

related🔬Is disrupted sleep a cause or consequence of neurodegenerati50%

related🔬Anti-amyloid antibodies (lecanemab, donanemab) have ~0.1% br50%

related🔬APOE4 differs from APOE3 by C112R causing domain interaction50%

see_also🧪Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna50%

see_also🧪Circadian Rhythm Entrainment of Reactive Astrocytes50%

see_also🧪Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A50%

see_also🧪Temporal Decoupling via Circadian Clock Reset50%

see_also🧪Circadian Clock-Autophagy Synchronization50%

see_also🧪Flotillin-1 Stabilization Compounds50%

see_also🧪GFAP-Positive Reactive Astrocyte Subtype Delineation50%

see_also🧪APOE-Dependent Autophagy Restoration50%

see_also🧪Nutrient-Sensing Epigenetic Circuit Reactivation50%

see_also🧪The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction50%

see_also🧪TFEB-PGC1α Mitochondrial-Lysosomal Decoupling50%

see_also🧪Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam50%

see_also🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer50%

see_also🧪APOE Isoform Conversion Therapy50%

see_also🧪APOE4 Allosteric Rescue via Small Molecule Chaperones50%

see_also🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction50%

see_also🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%

see_also🧪APOE4-Selective Lipid Nanoemulsion Therapy50%

see_also🧪Competitive APOE4 Domain Stabilization Peptides50%

see_also🧪APOE Isoform Expression Across Glial Subtypes50%

see_also🧪CYP46A1 Overexpression Gene Therapy50%

see_also🧪Pericyte Contractility Reset via Selective PDGFR-β Agonism50%

see_also🧪Magnetosonic-Triggered Transferrin Receptor Clustering50%

see_also🧪TREM2 Conformational Stabilizers for Synaptic Discrimination50%

see_also🧪APOE-TREM2 Interaction Modulation50%

see_also🧪TREM2-Mediated Selective Aggregate Clearance Pathway50%

see_also🧪TREM2-Dependent Microglial Senescence Transition50%

see_also🧪TREM2-mediated microglial tau clearance enhancement50%

see_also🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%

see_also🧪SASP-Driven Aquaporin-4 Dysregulation50%

see_also🧪Aquaporin-4 Polarization Rescue50%

see_also🧪HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor50%

see_also🧪Lysosomal Positioning Dynamics Modulation50%

see_also🧪Trans-Synaptic Adhesion Molecule Modulation50%

see_also🧪Selective HDAC3 Inhibition with Cognitive Enhancement50%

see_also🧪HDAC3-Selective Inhibition for Clock Reset50%

see_also📖LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for APOE45%

see_also📖KarXT for Alzheimer's Disease Cognitive Impairment - MI45%

see_also📖A Phase 3, Randomised, Double-blinded, Placebo-controlled St45%

see_also📖Novartis Alzheimer's Disease Phase 2 Trial (NCT0709451645%

see_also📖Rotigotine and Rivastigmine Combination Therapy for Alzheime45%

see_also📖APOE4 (Apolipoprotein E4)45%

see_also📖Cross-National Cancer-Dementia Correlation and Shared Diseas45%

see_also📖Cancer-Dementia Inverse Correlation: Epidemiological Evidenc45%

see_also📖SNCA — Alpha-Synuclein Gene Entity Page45%

see_also📖NLRP3 Inflammasome Inhibitors for Parkinson's Disease45%

mentions📖BioArctic AB40%

mentions📖Cognicann40%

mentions📖Idorsia Pharmaceuticals Ltd.40%

mentions📖Kinexx Co., Ltd.40%

mentions📖Moscow State University40%

mentions📖Peking University40%

mentions📖Polyneuron Pharmaceuticals AG40%

mentions📖Priavoid GmbH40%

mentions📖Simcere Pharmaceutical Co., Ltd.40%

mentions📖University of Maastricht40%

mentions📖University of Rostock40%

mentions📖cu-anschutz-medical-campus40%

mentions🔬Investigate how lipid raft composition (cholesterol metaboli40%

mentions🔬Is disrupted sleep a cause or consequence of neurodegenerati40%

mentions🔬Anti-amyloid antibodies (lecanemab, donanemab) have ~0.1% br40%

mentions🔬APOE4 differs from APOE3 by C112R causing domain interaction40%

mentions🔬Analyze circuit-level changes in neurodegeneration using All40%

related🧪Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m40%