Mitochondrial Proteostasis Coupling Therapy

graph TD
    ATP6V1A["ATP6V1A"] -->|encodes subunit of| v_ATPase["v-ATPase"]
    ATP6V1A_1["ATP6V1A"] -->|encodes subunit of| lysosomal_acidification["lysosomal acidification"]
    lysosomal_acidification_2["lysosomal acidification"] -->|associated with| PROTEIN_DEGRADATION["PROTEIN_DEGRADATION"]
    HSPA1A["HSPA1A"] -->|regulates| PROTEIN_FOLDING["PROTEIN_FOLDING"]
    PROTEIN_FOLDING_3["PROTEIN_FOLDING"] -.->|inhibits| PROTEIN_AGGREGATION["PROTEIN_AGGREGATION"]
    v_ATPase_4["v-ATPase"] -->|modulates| lysosomal_pH["lysosomal pH"]
    lysosomal_acidification_5["lysosomal acidification"] -->|enables| protein_degradation["protein degradation"]
    protein_degradation_6["protein degradation"] -->|protects against| neurodegeneration["neurodegeneration"]
    ATF5["ATF5"] -->|transcriptional ac| UPRmt["UPRmt"]
    UPRmt_7["UPRmt"] -->|regulates| mitochondrial_proteostasi["mitochondrial proteostasis"]
    mitochondrial_proteostasi_8["mitochondrial proteostasis"] -->|resists| seed_induced_protein_misf["seed-induced protein misfolding"]
    HSPA1A_9["HSPA1A"] -->|facilitates| protein_folding["protein folding"]
    style ATP6V1A fill:#ce93d8,stroke:#333,color:#000
    style v_ATPase fill:#4fc3f7,stroke:#333,color:#000
    style ATP6V1A_1 fill:#ce93d8,stroke:#333,color:#000
    style lysosomal_acidification fill:#81c784,stroke:#333,color:#000
    style lysosomal_acidification_2 fill:#81c784,stroke:#333,color:#000
    style PROTEIN_DEGRADATION fill:#81c784,stroke:#333,color:#000
    style HSPA1A fill:#ce93d8,stroke:#333,color:#000
    style PROTEIN_FOLDING fill:#4fc3f7,stroke:#333,color:#000
    style PROTEIN_FOLDING_3 fill:#4fc3f7,stroke:#333,color:#000
    style PROTEIN_AGGREGATION fill:#4fc3f7,stroke:#333,color:#000
    style v_ATPase_4 fill:#4fc3f7,stroke:#333,color:#000
    style lysosomal_pH fill:#4fc3f7,stroke:#333,color:#000
    style lysosomal_acidification_5 fill:#81c784,stroke:#333,color:#000
    style protein_degradation fill:#4fc3f7,stroke:#333,color:#000
    style protein_degradation_6 fill:#4fc3f7,stroke:#333,color:#000
    style neurodegeneration fill:#ef5350,stroke:#333,color:#000
    style ATF5 fill:#ce93d8,stroke:#333,color:#000
    style UPRmt fill:#81c784,stroke:#333,color:#000
    style UPRmt_7 fill:#81c784,stroke:#333,color:#000
    style mitochondrial_proteostasi fill:#4fc3f7,stroke:#333,color:#000
    style mitochondrial_proteostasi_8 fill:#4fc3f7,stroke:#333,color:#000
    style seed_induced_protein_misf fill:#4fc3f7,stroke:#333,color:#000
    style HSPA1A_9 fill:#ce93d8,stroke:#333,color:#000
    style protein_folding fill:#4fc3f7,stroke:#333,color:#000