gene

ERK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ERK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

172Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

ERK2 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, implicated in. Associated with Aging, Als, Alzheimer. Connected to 122 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MAPK1
Full Name	Mitogen-Activated Protein Kinase 1
Aliases	ERK2, p42 MAPK, PRKM1
Chromosome	22q11.22
Protein Family	MAP kinase family, CMGC group
Protein Type	Kinase
Function	is a protein involved in various cellular processes relevant to neurodegeneration.
Subcellular Localization	Cytoplasm, nucleus
Molecular Weight	41 kDa
Amino Acids	360 aa
Pathways	MAPK, Mapk, MAPK signaling, MAPK pathway
UniProt ID	P28482
NCBI Gene ID	5594
Ensembl ID	ENSG00000100030
GeneCards	MAPK1
Human Protein Atlas	MAPK1
Associated Diseases	ALS, Aging, Alzheimer, Cancer, Carcinoma
Known Drugs/Compounds	Zuojin Pill, Chrysotoxine, DEP, DMP, DOP
Interactions	MAP1LC3B, MTOR, TLR4, LC3, TFEB, AKT
KG Connections	948 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ERK2 — AlphaFold P28482 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ERK2["ERK2"] -->|"phosphorylates"| PKM2["PKM2"]
    ERK2["ERK2"] -->|"activates"| Cancer["Cancer"]
    ERK2["ERK2"] -->|"activates"| Carcinoma["Carcinoma"]
    ERK2["ERK2"] -->|"activates"| Tumor["Tumor"]
    ERK2["ERK2"] -->|"activates"| Als["Als"]
    ERK2["ERK2"] -->|"activates"| Ms["Ms"]
    DRP1["DRP1"] -->|"activates"| ERK2["ERK2"]
    TNF["TNF"] -->|"associated"| ERK2["ERK2"]
    FERROPTOSIS["FERROPTOSIS"] -->|"associated"| ERK2["ERK2"]
    ERK1["ERK1"] -->|"associated"| ERK2["ERK2"]
    style ERK2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (112)

Target	Relation	Type	Str
Mitochondrial Fission	mediates	process	0.90
PKM2	phosphorylates	protein	0.80
Mapk	associated_with	pathway	0.80
Als	activates	disease	0.75
Mapk	activates	pathway	0.70
ERK	activates	gene	0.70
Autophagy	activates	pathway	0.70
Cancer	activates	disease	0.65
Carcinoma	activates	disease	0.65
Tumor	activates	disease	0.65
Ms	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Parkinson	activates	disease	0.65
Alzheimer	activates	disease	0.65
Huntington	activates	disease	0.65
Heart Failure	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Fibrosis	activates	disease	0.65
Als	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	regulates	disease	0.65
Cancer	phosphorylates	disease	0.65
Melanoma	associated_with	disease	0.65
Hypertension	activates	disease	0.65
Tumor	implicated_in	disease	0.65
Cancer	implicated_in	disease	0.65
Aging	implicated_in	disease	0.65
Carcinoma	implicated_in	disease	0.65
Als	inhibits	disease	0.65
Infection	activates	disease	0.65
Diabetes	activates	disease	0.65
Lymphoma	activates	disease	0.65
DRP1	activates	gene	0.60
ATF4	activates	gene	0.60
TFAM	activates	gene	0.60
BCL2	activates	gene	0.60
BAX	activates	gene	0.60
ERK1	activates	gene	0.60
ERK1	regulates	gene	0.60
CHOP	activates	gene	0.60
MIRO1	activates	gene	0.60
DRP1	phosphorylates	gene	0.60
CYLD	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
MAPK3	activates	gene	0.60
MAPK1	activates	gene	0.60
VEGF	activates	gene	0.60
LC3	activates	gene	0.60
MAPK3	associated_with	gene	0.60
STAT3	associated_with	gene	0.60

Incoming (60)

Source	Relation	Type	Str
ERK1	activates	gene	0.80
ERK1	associated_with	gene	0.70
DRP1	activates	gene	0.60
TNF	associated_with	gene	0.60
MAPK3	associated_with	gene	0.60
MAPK1	associated_with	gene	0.60
NLRP3	activates	gene	0.60
ULK1	associated_with	gene	0.60
BTRC	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
CYLD	associated_with	gene	0.60
ERK1	regulates	gene	0.60
MAPK3	activates	gene	0.60
MAPK1	activates	gene	0.60
MYC	expressed_in	gene	0.60
DUSP1	activates	gene	0.60
DUSP6	activates	gene	0.60
DRP1	phosphorylates	gene	0.60
BAX	activates	gene	0.60
TFAM	activates	gene	0.60
BCL2	activates	gene	0.60
TRIM16	implicated_in	gene	0.60
PI3K	activates	gene	0.60
SRC	activates	gene	0.60
IGF1	activates	gene	0.60
NTS	activates	gene	0.60
EGFR	activates	gene	0.60
MAPK1	causes	gene	0.60
SLC6A4	activates	gene	0.60
CASP3	activates	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
MITOPHAGY	activates	gene	0.60
CYTOKINES	activates	gene	0.60
CANCER	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
ERK	regulates	gene	0.60
CANCER	associated_with	gene	0.60
RAS	activates	gene	0.60
CANCER	phosphorylates	gene	0.60
APOPTOSIS	activates	gene	0.60
ERK	activates	gene	0.60
GENES	activates	gene	0.60
EXERCISE	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEURODEGENERATIVE DISORDERS	activates	gene	0.60
HUNTINGTON	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
PARKINSON	activates	gene	0.60
AND	associated_with	gene	0.60
MITOCHONDRIA	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ERK2

Understanding Entity Pages

Summary

Wiki Pages (21)

ERK2 (MAPK1)

erk-mapk-signaling-neurodegeneration

ERK1 Protein

ERK2 Protein

GDNF Family Neurotrophic Factor Signaling Pathway in Neurodegeneration

NTF5 — Neurotrophin 5

AGER/RAGE Protein

MAP2K2 Gene

Protein Aggregation in Neurodegenerative Disease Comparison

TFEB Autophagy Pathway

MAPK4 Gene

ERK1 (MAPK3) — Extracellular Signal-Regulated Kinase 1

MEK2 Protein

MEK1 Protein

ERK2 Protein

mapk1-protein

RPS6KA1 — Ribosomal Protein S6 Kinase A1

MAPK3 Gene - ERK1