gene

ATP7A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATP7A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

51Connections

0Hypotheses

0Analyses

40Outgoing

11Incoming

0Experiments

0Debates

Summary

ATP7A is a gene implicated in neurodegeneration research. Key relationships include: expressed in, inhibits, interacts with. Associated with Als, Cancer, Carcinoma. Connected to 15 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ATP7A
Full Name	Copper-Transport ATPase
Chromosome	Xq21.1
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	most tissues except the liver, making it the primary copper transporter for extrahepatic copper metabolism
Molecular Weight	163 kDa
Amino Acids	1500 aa
UniProt ID	[Q9Y5K9](https://www.uniprot.org/uniprot/Q9Y5K9)
Ensembl ID	ENSG00000136939
OMIM	300011
GeneCards	ATP7A
Human Protein Atlas	ATP7A
8 Transmembrane Helices	Form the copper translocation pore
Copper Binding Sites	6 N-terminal CXXC motifs for copper binding
Gate Region	Regulates access to the transport channel
Associated Diseases	developmental delay, Menkes disease, neurodegeneration
Interactions	AND, Aβ, CP, FDX1, P53, VCP
KG Connections	51 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ATP7A

gene · 959 words

→

ATP7A Protein - Copper-transporting ATPase 1

protein · 2524 words

→

Pathway Diagram

graph TD
    ATP7A["<b>ATP7A</b>"]
    Als{"Als"}
    ATP7A -->|"inhibits"| Als
    Ms{"Ms"}
    ATP7A -->|"expressed in"| Ms
    Cancer{"Cancer"}
    ATP7A -->|"expressed in"| Cancer
    Carcinoma{"Carcinoma"}
    ATP7A -->|"inhibits"| Carcinoma
    P53["P53"]
    ATP7A -->|"activates"| P53
    SOD1["SOD1"]
    ATP7A -->|"expressed in"| SOD1
    SP1["SP1"]
    ATP7A -->|"expressed in"| SP1
    ABCG1["ABCG1"]
    ATP7A -->|"expressed in"| ABCG1
    SLC22A5["SLC22A5"]
    ATP7A -->|"expressed in"| SLC22A5
    CANCER["CANCER"]
    ATP7A -->|"expressed in"| CANCER
    ABCG2["ABCG2"]
    ATP7A -->|"expressed in"| ABCG2
    neurodegeneration["neurodegeneration"]
    ATP7A -->|"implicated in"| neurodegeneration
    CP["CP"]
    CP -->|"interacts with"| ATP7A
    ABCD3["ABCD3"]
    ABCD3 -->|"expressed in"| ATP7A
    ABCA2["ABCA2"]
    ABCA2 -->|"expressed in"| ATP7A
    style ATP7A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (40)

Target	Relation	Type	Str
Menkes disease	causes	disease	0.90
copper homeostasis	regulates	process	0.88
copper	regulates	chemical	0.80
copper transport	participates_in	biological_process	0.80
Ferroptosis	regulates	process	0.75
neurodegeneration	associated_with	disease	0.70
developmental delay	associated_with	phenotype	0.70
Ms	expressed_in	disease	0.65
Als	inhibits	disease	0.65
Alzheimer	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Carcinoma	inhibits	disease	0.65
Alzheimer	transports	disease	0.65
Blood-Brain Barrier	transports	pathway	0.60
hippocampus	expressed_in	brain_region	0.60
Oxidative Stress	transports	pathway	0.60
Amyloid	transports	pathway	0.60
CANCER	expressed_in	gene	0.60
endothelial cells	expressed_in	cell_type	0.60
Oxidative Stress	expressed_in	pathway	0.60
Blood-Brain Barrier	expressed_in	pathway	0.60
Endothelial	activates	cell_type	0.60
Endothelial	transports	cell_type	0.60
P53	activates	gene	0.60
ATP7B	translocates_to	gene	0.60
VCP	interacts_with	gene	0.60
ALZHEIMER	transports	gene	0.60
Aβ	activates	protein	0.60
ABCG1	expressed_in	gene	0.60
SLC22A5	expressed_in	gene	0.60
ABCG2	expressed_in	gene	0.60
FDX1	activates	gene	0.60
CRISPR-Cas	participates_in	pathway	0.60
SOD1	expressed_in	gene	0.60
SP1	expressed_in	gene	0.60
Endothelial Cell	expressed_in	cell_type	0.55
Hippocampus	expressed_in	brain_region	0.55
Hippocampus	activates	entity	0.50
ENDOTHELIAL	activates	concept	0.50
ENDOTHELIAL CELLS	activates	concept	0.50

Incoming (11)

Source	Relation	Type	Str
CP	interacts_with	protein	0.70
ALZHEIMER	transports	gene	0.60
OXIDATIVE STRESS	transports	gene	0.60
ROS	transports	gene	0.60
AND	activates	gene	0.60
ABCD3	expressed_in	gene	0.60
ABCA2	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
ROS	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	transports	gene	0.60
AMYLOID	transports	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity