concept

FDX1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FDX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

82Connections

0Hypotheses

0Analyses

50Outgoing

25Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	FDX1
Related Diseases	Hepatocellular Carcinoma, HCC Cell Proliferation, HCC Cell Invasion, ROS, hepatocellular carcinoma
Related Pathways	PI3K/AKT, PI3K

Wiki Pages (4)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    FDX1["FDX1"]
    FDX1 -->|"regulates"| mitophagy["mitophagy"]
    FDX1 -->|"downregulates"| Hepatocellular_Carcinoma["Hepatocellular Carcinoma"]
    FDX1 -->|"inhibits"| HCC_Cell_Proliferation["HCC Cell Proliferation"]
    FDX1 -->|"inhibits"| HCC_Cell_Invasion["HCC Cell Invasion"]
    FDX1 -->|"inhibits"| ROS["ROS"]
    FDX1 -.protects against.-> hepatocellular_carcinoma["hepatocellular carcinoma"]
    FDX1 -->|"inhibits"| PI3K_AKT["PI3K/AKT"]
    MITOPHAGY["MITOPHAGY"] -->|"activates"| FDX1
    DLAT["DLAT"] -->|"activates"| FDX1
    AKT["AKT"] -->|"activates"| FDX1
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"activates"| FDX1
    LC3["LC3"] -->|"activates"| FDX1
    GFP["GFP"] -->|"activates"| FDX1
    ROS -->|"activates"| FDX1
    RNA["RNA"] -->|"activates"| FDX1

Outgoing (57)

Target	Relation	Type	Str
mitophagy	regulates	process	0.95
Hepatocellular Carcinoma	downregulates	disease	0.95
HCC Cell Proliferation	inhibits	phenotype	0.92
HCC Cell Invasion	inhibits	phenotype	0.92
ROS	inhibits	phenotype	0.90
hepatocellular carcinoma	protects_against	disease	0.90
ROS production	induces	process	0.90
ferroptosis	mediates	process	0.90
hepatocellular carcinoma	biomarker_for	disease	0.88
PI3K/AKT	inhibits	pathway	0.85
Metabolic Reprogramming	regulates	process	0.85
PI3K	activates	pathway	0.80
Ferroptosis	involved_in	process	0.80
Alzheimer	inhibits	disease	0.65
Als	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Carcinoma	activates	disease	0.65
ALS	inhibits	disease	0.65
Als	expressed_in	disease	0.65
AUTOPHAGY	associated_with	gene	0.60
ROS	activates	gene	0.60
Autophagy	associated_with	pathway	0.60
Mitophagy	activates	pathway	0.60
Pi3K/Akt	activates	pathway	0.60
CREB	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
HSP70	activates	gene	0.60
SYP	inhibits	gene	0.60
BAX	activates	gene	0.60
PARKINSON	inhibits	gene	0.60
TRKB	inhibits	gene	0.60
Synaptic Plasticity	inhibits	pathway	0.60
Apoptosis	activates	pathway	0.60
Neuron	activates	cell_type	0.60
RNA	activates	gene	0.60
LC3	activates	gene	0.60
AND	activates	gene	0.60
DLAT	activates	gene	0.60
Bdnf	inhibits	protein	0.60
Akt	activates	protein	0.60
App	activates	protein	0.60
Rb	inhibits	protein	0.60
CD4	expressed_in	gene	0.60
GLS	associated_with	gene	0.60
Immune Response	expressed_in	pathway	0.60
Mitochondrial Function	expressed_in	pathway	0.60
T Cell	expressed_in	cell_type	0.60
autophagy pathway	participates_in	pathway	0.60

Incoming (25)

Source	Relation	Type	Str
Copper	upregulates	compound	0.85
MITOPHAGY	activates	gene	0.60
DLAT	activates	gene	0.60
AKT	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
LC3	activates	gene	0.60
GFP	activates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
ROS	activates	gene	0.60
RNA	activates	gene	0.60
AND	activates	gene	0.60
PARKINSON	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
TRKB	inhibits	gene	0.60
NEURODEGENERATIVE DISEASES	inhibits	gene	0.60
CREB	inhibits	gene	0.60
SYP	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
HSP70	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
PARKINSON'S DISEASE	inhibits	gene	0.60
PI3K	activates	gene	0.60
BAX	activates	gene	0.60
ATP7A	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FDX1

Understanding Entity Pages

Wiki Pages (4)

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