Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about COPPER: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | COPPER |
Knowledge base pages for this entity
graph TD
COPPER["COPPER"]
COPPER -->|"binds_to"| GPX4["GPX4"]
COPPER -->|"promotes"| ferroptosis["ferroptosis"]
COPPER -->|"downregulates"| BNIP3["BNIP3"]
COPPER -->|"mediates"| Cuproptosis["Cuproptosis"]
COPPER -->|"binds"| Lipoylated_TCA_Cycle_Component["Lipoylated TCA Cycle Components"]
COPPER -->|"activates"| autophagy["autophagy"]
COPPER -->|"activates"| NFKB["NFKB"]
DMSA["DMSA"] -->|"targets"| COPPER
CP["CP"] -->|"binds"| COPPER
ATP7A["ATP7A"] -->|"regulates"| COPPER
Amyloid__["Amyloid beta"] -->|"interacts"| COPPER| Target | Relation | Type | Str |
|---|---|---|---|
| GPX4 | binds_to | protein | 0.95 |
| ferroptosis | promotes | process | 0.95 |
| BNIP3 | downregulates | gene | 0.95 |
| Synaptic Damage | associated_with | phenotype | 0.95 |
| Cuproptosis | mediates | process | 0.95 |
| Cognitive Impairment | causes | phenotype | 0.95 |
| Autophagy | activates | process | 0.95 |
| Spermatogenesis Disorder | causes | disease | 0.93 |
| Lipoylated TCA Cycle Components | binds | protein | 0.90 |
| BAX | upregulates | protein | 0.90 |
| OXIDATIVE STRESS | promotes | process | 0.90 |
| APOPTOSIS | promotes | process | 0.90 |
| CREB | suppresses | protein | 0.90 |
| NTRK1 | downregulates | protein | 0.90 |
| autophagy | activates | process | 0.85 |
| GPX4 | upstream_of | protein | 0.85 |
| BDNF | downregulates | protein | 0.85 |
| DLAT | upregulates | protein | 0.85 |
| HSP70 | upregulates | protein | 0.85 |
| PSD95 | inhibits | protein | 0.85 |
| SYP | inhibits | protein | 0.85 |
| NFKB | activates | protein | 0.85 |
| ALZHEIMER'S DISEASE | associated_with | disease | 0.85 |
| PARKINSON'S DISEASE | associated_with | disease | 0.85 |
| Synaptic Plasticity | associated_with | process | 0.85 |
| FDX1 | upregulates | protein | 0.85 |
| SLC40A1 | regulates | gene | 0.80 |
| ferroptosis | induces | process | 0.80 |
| cancer | therapeutic_target | disease | 0.80 |
| LOXL4 | associated_with | enzyme | 0.80 |
| PSD95 | downregulates | protein | 0.80 |
| SYP | downregulates | protein | 0.80 |
| Microglia | associated_with | cell_type | 0.80 |
| Wilson's disease | associated_with | disease | 0.70 |
| Tumor Metastasis | contributes_to | biological_process | 0.70 |
| mitochondrial membrane potential | inhibits | process | 0.70 |
| OPA1 | inhibits | gene | 0.70 |
| MFN1 | inhibits | gene | 0.70 |
| DRP1 | activates | gene | 0.70 |
| PINK1/Parkin-dependent mitophagy | activates | pathway | 0.70 |
| mitochondrial ROS | promotes | process | 0.70 |
| oxidative stress | activates | process | 0.70 |
| apoptosis | activates | process | 0.70 |
| Parkinson's Disease | biomarker_for | disease | 0.70 |
| PGC-1α | inhibits | gene | 0.70 |
| MTOR | inhibits | protein | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||