Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BCL-XL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | BCL |
| Molecular Weight | 26 kDa |
| Pathways | Pyroptosis, Necroptosis, mitophagy |
| GeneCards | BCL |
| Human Protein Atlas | BCL |
| Interactions | BCL-2, Proteins, EFNB1, MLKL, GSDMD, CASPASE-1 |
| KG Connections | 27 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
BCL_XL["<b>BCL-XL</b>"]
Apoptosis["Apoptosis"]
BCL_XL -->|"regulates"| Apoptosis
BCL_2(["BCL-2"])
BCL_XL -.->|"inhibits"| BCL_2
Proteins(["Proteins"])
BCL_XL -.->|"inhibits"| Proteins
apoptosis["apoptosis"]
BCL_XL -.->|"inhibits"| apoptosis
Pyroptosis["Pyroptosis"]
BCL_XL -.->|"inhibits"| Pyroptosis
Necroptosis["Necroptosis"]
BCL_XL -.->|"inhibits"| Necroptosis
EFNB1(["EFNB1"])
EFNB1 -->|"activates"| BCL_XL
MLKL(["MLKL"])
MLKL -.->|"inhibits"| BCL_XL
GSDMD(["GSDMD"])
GSDMD -.->|"inhibits"| BCL_XL
CASPASE_1(["CASPASE-1"])
CASPASE_1 -.->|"inhibits"| BCL_XL
style BCL_XL fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7| Target | Relation | Type | Str |
|---|---|---|---|
| Apoptosis | regulates | process | 0.70 |
| BCL-2 | inhibits | protein | 0.50 |
| Proteins | inhibits | protein | 0.50 |
| apoptosis | inhibits | process | 0.50 |
| Pyroptosis | inhibits | pathway | 0.50 |
| Necroptosis | inhibits | pathway | 0.50 |
| cancer | inhibits | disease | 0.50 |
| BCL-2 | activates | protein | 0.50 |
| Proteins | activates | protein | 0.50 |
| TUMOR | expressed_in | disease | 0.50 |
| CELL SURVIVAL | expressed_in | concept | 0.50 |
| mitophagy | activates | pathway | 0.50 |
| apoptosis | activates | process | 0.50 |
| HEPATOCYTES | activates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| EFNB1 | activates | gene | 0.50 |
| MLKL | inhibits | gene | 0.50 |
| GSDMD | inhibits | protein | 0.50 |
| CASPASE-1 | inhibits | protein | 0.50 |
| BCL2L1 | inhibits | gene | 0.50 |
| MCL1 | inhibits | gene | 0.50 |
| BCL2 | inhibits | gene | 0.50 |
| caspases | activates | disease | 0.50 |
| EGFR | inhibits | gene | 0.50 |
| EGFR | expressed_in | gene | 0.50 |
| BCL2L1 | expressed_in | gene | 0.50 |
| STAT3 | activates | gene | 0.50 |
| JAK2 | activates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||