gene

BTRC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BTRC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections
0Hypotheses
0Analyses
12Outgoing
11Incoming

Summary

Beta-Transducin Repeat Containing Protein - F-box ubiquitin ligase subunit involved in protein degradation and neurodegeneration

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🧬 Gene Info
Gene SymbolBTRC
Full NameBeta-Transducin Repeat Containing Protein
Chromosome10q24.32
Protein TypeLigase
Functionis a critical regulator of numerous cellular processes, including cell cycle progression, DNA damage responses, circadian rhythm, inflammatory signaling, and protein quality control.
Amino Acids542 aa
PathwaysAutophagy, Inflammasome, Mitophagy, Nlrp3 Inflammasome
UniProt ID[Q9Y297](https://www.uniprot.org/uniprot/Q9Y297)
Ensembl IDENSG00000166167
GeneCardsBTRC
Human Protein AtlasBTRC
Recognition motifDSGxxS or DSxGxxS (where x is any amino acid)
Phosphorylation requirementBoth serine residues must be phosphorylated
Dimerization requirementβ-TrCP functions as a dimer
NF-κB pathwayIκBα, IκBβ, NF-κB2/p100, HBV X protein
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsCANCER, AUTOPHAGY, NLRP3, MITOPHAGY, CYTOKINES, MITOCHONDRIA
KG Connections23 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

BTRC Gene

gene · 1877 words

beta-catenin-protein

protein · 1814 words

F-Box/WD Repeat-Containing Protein 1 (β-TrCP1) Protein

protein · 622 words

Proteins

index · 296 words

Genes

index · 271 words

Pathway Diagram

graph TD
    BTRC["<b>BTRC</b>"]
    Als{"Als"}
    BTRC -->|"activates"| Als
    Cancer{"Cancer"}
    BTRC -->|"activates"| Cancer
    CANCER["CANCER"]
    BTRC -->|"activates"| CANCER
    ERK1["ERK1"]
    BTRC -->|"associated with"| ERK1
    AUTOPHAGY["AUTOPHAGY"]
    BTRC -->|"activates"| AUTOPHAGY
    ERK2["ERK2"]
    BTRC -->|"associated with"| ERK2
    Autophagy(["Autophagy"])
    BTRC -->|"activates"| Autophagy
    Proteasome(["Proteasome"])
    BTRC -->|"associated with"| Proteasome
    Inflammasome(["Inflammasome"])
    BTRC -->|"activates"| Inflammasome
    Mitophagy(["Mitophagy"])
    BTRC -->|"activates"| Mitophagy
    Mapk(["Mapk"])
    BTRC -->|"associated with"| Mapk
    neurodegeneration["neurodegeneration"]
    BTRC -->|"implicated in"| neurodegeneration
    MAPK3["MAPK3"]
    MAPK3 -->|"associated with"| BTRC
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"activates"| BTRC
    MAPK1["MAPK1"]
    MAPK1 -->|"associated with"| BTRC
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"activates"| BTRC
    NLRP3["NLRP3"]
    NLRP3 -->|"activates"| BTRC
    ULK1["ULK1"]
    ULK1 -->|"associated with"| BTRC
    style BTRC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (12)

TargetRelationTypeStr
Alsactivatesdisease0.65
Canceractivatesdisease0.65
ERK1associated_withgene0.60
ERK2associated_withgene0.60
CANCERactivatesgene0.60

Incoming (11)

SourceRelationTypeStr
MAPK3associated_withgene0.60
MAPK1associated_withgene0.60
NLRP3activatesgene0.60
ULK1associated_withgene0.60
ERK2associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found