concept

CASPASE8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASPASE8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

32Connections

0Hypotheses

0Analyses

21Outgoing

11Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	Caspase-8
Summary	Page for Caspase-8
Key Genes/Proteins	BCL2, FOXO1, BAX, JUN, EHMT2, CASPASE3
Related Diseases	Lymphoma, Aging, Heart Failure, Cancer, ALS
Related Pathways	Apoptosis

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Caspase-8

protein · 879 words

→

Pathway Diagram

graph TD
    CASPASE8["CASPASE8"]
    CASPASE8 -->|"inhibits"| Aging["Aging"]
    CASPASE8 -->|"inhibits"| Heart_Failure["Heart Failure"]
    CASPASE8 -->|"inhibits"| Cancer["Cancer"]
    CASPASE8 -->|"inhibits"| ALS["ALS"]
    CASPASE8 -->|"inhibits"| Als["Als"]
    CASPASE8 -->|"inhibits"| CANCER["CANCER"]
    CASPASE8 -->|"inhibits"| Apoptosis["Apoptosis"]
    CASPASE8 -->|"inhibits"| APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"inhibits"| CASPASE8
    JUN["JUN"] -->|"inhibits"| CASPASE8
    TNFA["TNFA"] -->|"activates"| CASPASE8
    CANCER -->|"inhibits"| CASPASE8

Outgoing (21)

Target	Relation	Type	Str
Lymphoma	associated_with	disease	0.65
Aging	inhibits	disease	0.65
Heart Failure	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Als	inhibits	disease	0.65
BCL2	associated_with	gene	0.60
FOXO1	associated_with	gene	0.60
BAX	associated_with	gene	0.60
JUN	inhibits	gene	0.60
EHMT2	associated_with	gene	0.60
CASPASE3	associated_with	gene	0.60
CANCER	inhibits	gene	0.60
Apoptosis	inhibits	pathway	0.60
APOPTOSIS	inhibits	gene	0.60
BCL-2	associated_with	gene	0.60
B Cell	inhibits	cell_type	0.60
Caspase	associated_with	protein	0.60
Raf	inhibits	protein	0.60
Ras	associated_with	protein	0.60
B Cell	expressed_in	cell_type	0.55

Incoming (11)

Source	Relation	Type	Str
EHMT2	associated_with	gene	0.60
CASPASE3	associated_with	gene	0.60
BAX	associated_with	gene	0.60
JUN	inhibits	gene	0.60
BCL2	associated_with	entity	0.60
TNFA	activates	protein	0.60
FOXO1	associated_with	gene	0.60
APOPTOSIS	inhibits	gene	0.60
BCL-2	associated_with	gene	0.60
CANCER	inhibits	gene	0.60
AND	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found