Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CATHEPSIND: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet.
No AI portrait yet
| Gene Symbol | CTSD |
| Full Name | Cathepsin D |
| Aliases | CPSD, CLN10 |
| Chromosome | 11p15.5 |
| Protein Type | Protease |
| Function | is a lysosomal aspartic protease encoded by the CTSD gene. |
| Primary Expression | Brain, liver, macrophages, neurons, microglia |
| Molecular Weight | 48 kDa |
| Pathways | Akt, Angiogenesis, Apoptosis, Autophagy, Blood-Brain Barrier |
| UniProt ID | P07339 |
| NCBI Gene ID | 1509 |
| Ensembl ID | ENSG00000103811 |
| GeneCards | CTSD |
| Human Protein Atlas | CTSD |
| Associated Diseases | AD, ADH, Aging, ALI, Als |
| Known Drugs/Compounds | CHLOROQUINE, COENZYME Q10, H2S, rapamycin, RAPAMYCIN |
| Interactions | ABCA1, ABCD3, ACTB, Actin, ADRA2A, AGING |
| SciDEX Hypotheses | Cathepsin D Enhancement for Tau Degradation |
| KG Connections | 1554 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CATHEPSIND["CATHEPSIND"]
neurodegeneration["neurodegeneration"]
CATHEPSIND -->|"implicated_in"| neurodegeneration
style CATHEPSIND fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CATHEPSIND in their description or question text
No additional research found