Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CD200R1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CD200 Receptor 1 - an inhibitory immune receptor that regulates microglial activation and neuroinflammation in neurodegenerative diseases
| Gene Symbol | CD200R1 |
| Aliases | CD200 Receptor 1 |
| Chromosome | 3q13.2 |
| Function | encodes a type I transmembrane protein with extracellular immunoglobulin-like domains, a transmembrane region, and a cytoplasmic tail containing multiple motifs that mediate inhibitory signaling. |
| Molecular Weight | 50 kDa |
| Amino Acids | 436 aa |
| Ensembl ID | ENSG00000163508 |
| GeneCards | CD200R1 |
| Human Protein Atlas | CD200R1 |
| PI3K/Akt pathway modulation | The receptor can activate PI3K signaling that promotes cell survival and anti-inflammatory phenotypes |
| MAPK pathway inhibition | CD200R1 signaling dampens ERK and p38 MAPK activation in response to inflammatory stimuli |
| NF-κB suppression | The receptor inhibits NF-κB nuclear translocation and transcriptional activity |
| STAT signaling | CD200R1 can influence STAT1 and STAT3 phosphorylation states |
| Associated Diseases | Parkinson, neurodegeneration |
| Interactions | IL10, CD200, MRC1, TGFB1, MICROGLIA |
| KG Connections | 39 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CD200R1["<b>CD200R1</b>"]
Parkinson{"Parkinson"}
CD200R1 -->|"associated_with"| Parkinson
Neuroinflammation{"Neuroinflammation"}
CD200R1 -->|"regulates"| Neuroinflammation
Multiple_Sclerosis{"Multiple Sclerosis"}
CD200R1 -->|"activates"| Multiple_Sclerosis
IL10(["IL10"])
CD200R1 -->|"associated_with"| IL10
TGFB1(["TGFB1"])
CD200R1 -->|"associated_with"| TGFB1
NFKB1["NFKB1"]
NFKB1 -->|"regulates"| CD200R1
CD200(["CD200"])
CD200 -->|"associated_with"| CD200R1
GENES(["GENES"])
GENES -->|"associated_with"| CD200R1
style CD200R1 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson | regulates | disease | 0.65 |
| Neuroinflammation | regulates | disease | 0.65 |
| Multiple Sclerosis | activates | disease | 0.65 |
| IL10 | associated_with | gene | 0.60 |
| TGFB1 | associated_with | gene | 0.60 |
| MRC1 | associated_with | gene | 0.60 |
| IL4 | associated_with | gene | 0.60 |
| CD200 | associated_with | gene | 0.60 |
| CD200 | inhibits | gene | 0.60 |
| Rb | therapeutic_target | protein | 0.60 |
| IL10 | binds_to | gene | 0.60 |
| TGFB1 | binds_to | gene | 0.60 |
| IL4 | binds_to | gene | 0.60 |
| CYTOKINES | therapeutic_target | gene | 0.60 |
| CYTOKINES | regulates | gene | 0.60 |
| IL-4 | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| GUT-BRAIN AXIS | regulates | gene | 0.60 |
| Cytokine | therapeutic_target | protein | 0.60 |
| Microglia | activates | cell_type | 0.60 |
| Neuron | regulates | cell_type | 0.60 |
| Dopaminergic | regulates | cell_type | 0.60 |
| Blood-Brain Barrier | inhibits | pathway | 0.60 |
| Endothelial | inhibits | cell_type | 0.60 |
| Ras | therapeutic_target | protein | 0.60 |
| Hippocampus | expressed_in | brain_region | 0.55 |
| microglia | expressed_in | cell_type | 0.55 |
| IL10 | interacts_with | gene | 0.50 |
| CD200 | interacts_with | gene | 0.50 |
| MRC1 | interacts_with | gene | 0.50 |
| IL-4 | interacts_with | concept | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||