gene

MRC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MRC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

103Connections

0Hypotheses

0Analyses

50Outgoing

46Incoming

Summary

MRC1 (CD206) encodes a C-type lectin receptor expressed on macrophages, dendritic cells, and microglia, mediating immune recognition, phagocytosis, and clearance of glycoproteins in neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	MRC1
Full Name	Mannose Receptor C Type 1 (CD206)
Aliases	CD206
Chromosome	10p12.33
Protein Type	Receptor
Function	encodes a C-type lectin receptor that plays a critical role in immune recognition and clearance of glycoproteins.
Molecular Weight	175 kDa
Amino Acids	1456 aa
Exons	30
Pathways	Immune Response
UniProt ID	[P22897](https://www.uniprot.org/uniprot/P22897)
Ensembl ID	ENSG00000138739
GeneCards	MRC1
Human Protein Atlas	MRC1
Associated Diseases	Als, Cirrhosis, Fibrosis
Interactions	ITGAM, CD14, JUN, CANCER, ICAM1, TLR2
KG Connections	103 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MRC1["<b>MRC1</b>"]
    Ms{"Ms"}
    MRC1 -->|"expressed in"| Ms
    Cancer{"Cancer"}
    MRC1 -->|"activates"| Cancer
    Tumor{"Tumor"}
    MRC1 -->|"activates"| Tumor
    Heart_Failure{"Heart Failure"}
    MRC1 -->|"regulates"| Heart_Failure
    Als{"Als"}
    MRC1 -->|"regulates"| Als
    Hepatitis{"Hepatitis"}
    MRC1 -->|"regulates"| Hepatitis
    Cardiac{"Cardiac"}
    MRC1 -->|"regulates"| Cardiac
    IL1B["IL1B"]
    MRC1 -->|"expressed in"| IL1B
    P53["P53"]
    MRC1 -->|"expressed in"| P53
    ITGAM["ITGAM"]
    MRC1 -->|"activates"| ITGAM
    TNF["TNF"]
    MRC1 -->|"expressed in"| TNF
    NF__B["NF-KappaB"]
    MRC1 -->|"expressed in"| NF__B
    ICAM1["ICAM1"]
    ICAM1 -->|"activates"| MRC1
    TREM2["TREM2"]
    TREM2 -->|"expressed in"| MRC1
    TLR2["TLR2"]
    TLR2 -->|"activates"| MRC1
    NFKBIA["NFKBIA"]
    NFKBIA -->|"activates"| MRC1
    CCR1["CCR1"]
    CCR1 -->|"regulates"| MRC1
    style MRC1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (57)

Target	Relation	Type	Str
Ms	expressed_in	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Heart Failure	regulates	disease	0.65
Als	regulates	disease	0.65
Hepatitis	regulates	disease	0.65
Cardiac	regulates	disease	0.65
Cirrhosis	associated_with	disease	0.65
Fibrosis	associated_with	disease	0.65
Als	associated_with	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
IL1B	expressed_in	gene	0.60
ITGAM	activates	gene	0.60
TNF	expressed_in	gene	0.60
CXCL2	expressed_in	gene	0.60
CD14	activates	gene	0.60
PPARG	expressed_in	gene	0.60
JUN	activates	gene	0.60
C1QB	regulates	gene	0.60
CD38	regulates	gene	0.60
CD163	regulates	gene	0.60
CXCL10	regulates	gene	0.60
HIF1A	associated_with	gene	0.60
PPAR	associated_with	gene	0.60
IL4	associated_with	gene	0.60
CASP1	associated_with	gene	0.60
IL13	associated_with	gene	0.60
FGF2	associated_with	gene	0.60
PI3K	expressed_in	gene	0.60
CD200	associated_with	gene	0.60
PPARG	associated_with	gene	0.60
APOE	associated_with	gene	0.60
Rb	therapeutic_target	protein	0.60
P53	expressed_in	gene	0.60
NF-ΚB	expressed_in	gene	0.60
CANCER	activates	gene	0.60
TNF-Α	expressed_in	gene	0.60
MSR1	expressed_in	gene	0.60
Nf-Κb	expressed_in	pathway	0.60
Oxidative Phosphorylation	expressed_in	pathway	0.60
Immune Response	regulates	pathway	0.60
P53 Pathway	expressed_in	pathway	0.60
IRS1	associated_with	gene	0.60
MIRNAS	expressed_in	gene	0.60
T Cell	expressed_in	cell_type	0.60
CYTOKINES	therapeutic_target	gene	0.60
AND	expressed_in	gene	0.60
RAS	expressed_in	gene	0.60
AND	associated_with	gene	0.60
GUT-BRAIN AXIS	regulates	gene	0.60

Incoming (46)

Source	Relation	Type	Str
ICAM1	activates	gene	0.60
TREM2	expressed_in	gene	0.60
TLR2	activates	gene	0.60
NFKBIA	activates	gene	0.60
CCR1	regulates	gene	0.60
TERT	associated_with	gene	0.60
IL1B	expressed_in	gene	0.60
CD14	activates	gene	0.60
TNF	expressed_in	gene	0.60
ITGAM	activates	gene	0.60
JUN	activates	gene	0.60
CXCL2	expressed_in	gene	0.60
ICAM1	associated_with	gene	0.60
PPARG	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
IL13	associated_with	gene	0.60
APOE	associated_with	gene	0.60
FGF2	associated_with	gene	0.60
CASP1	associated_with	gene	0.60
CD200	associated_with	gene	0.60
CD200R1	associated_with	gene	0.60
IL10	associated_with	gene	0.60
TGFB1	associated_with	gene	0.60
PPAR	associated_with	gene	0.60
AKT	expressed_in	gene	0.60
IL4	associated_with	gene	0.60
CCR2	associated_with	gene	0.60
GENES	expressed_in	gene	0.60
NF-ΚB	expressed_in	gene	0.60
P53	expressed_in	gene	0.60
MSR1	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
CANCER	activates	gene	0.60
TNF-Α	expressed_in	gene	0.60
RAS	expressed_in	gene	0.60
GENES	associated_with	gene	0.60
MIRNAS	expressed_in	gene	0.60
CYTOKINES	regulates	gene	0.60
IL-4	associated_with	gene	0.60
IRS1	associated_with	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
HIF1A	associated_with	gene	0.50
TGFB1	interacts_with	gene	0.50
CD200R1	interacts_with	gene	0.50
IL10	interacts_with	gene	0.50
CD200	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MRC1

Understanding Entity Pages

Summary

Wiki Pages (5)

MRC1 — Mannose Receptor C Type 1

CCR1

CD200 Gene