gene

CD200

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD200: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

60Connections

0Hypotheses

0Analyses

40Outgoing

20Incoming

Summary

CD200 membrane glycoprotein - immune checkpoint that regulates microglial activation and neuroinflammation in neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	CD200
Full Name	Cluster of Differentiation 200
Aliases	CD200 membrane glycoprotein
Chromosome	3q12-13
Function	is a widely expressed membrane glycoprotein that serves as a critical immune checkpoint molecule in the central nervous system.
Primary Expression	the central nervous system:
Molecular Weight	47 kDa
Amino Acids	269 aa
Exons	5
Pathways	Microglia Activation, Phagocytosis, inflammation, phagocytosis
UniProt ID	[P14210](https://www.uniprot.org/uniprot/P14210)
Ensembl ID	ENSG00000100288
OMIM	155730
GeneCards	CD200
Human Protein Atlas	CD200
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	MRC1, FGF2, FGF9, DIABETIC RETINOPATHY, AND, MICROGLIA
KG Connections	60 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (19)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CD200["<b>CD200</b>"]
    Neurodegeneration["Neurodegeneration"]
    CD200 -->|"activates"| Neurodegeneration
    ALS["ALS"]
    CD200 -->|"activates"| ALS
    Inflammation["Inflammation"]
    CD200 -->|"activates"| Inflammation
    Diabetes["Diabetes"]
    CD200 -->|"regulates"| Diabetes
    CD200R1["CD200R1"]
    CD200 -->|"associated with"| CD200R1
    IL10["IL10"]
    CD200 -->|"associated with"| IL10
    TGFB1["TGFB1"]
    CD200 -->|"associated with"| TGFB1
    MRC1["MRC1"]
    CD200 -->|"associated with"| MRC1
    IL4["IL4"]
    CD200 -->|"associated with"| IL4
    CYTOKINES["CYTOKINES"]
    CD200 -->|"therapeutic target"| CYTOKINES
    DIABETIC_RETINOPATHY["DIABETIC RETINOPATHY"]
    CD200 -->|"activates"| DIABETIC_RETINOPATHY
    AND["AND"]
    CD200 -->|"activates"| AND
    MICROGLIA["MICROGLIA"]
    CD200 -->|"activates"| MICROGLIA
    Phagocytosis["Phagocytosis"]
    CD200 -->|"activates"| Phagocytosis
    Microglia_Activation["Microglia Activation"]
    CD200 -->|"activates"| Microglia_Activation
    IL_4["IL-4"]
    CD200 -->|"associated with"| IL_4
    AND["AND"]
    CD200 -->|"associated with"| AND
    GUT_BRAIN_AXIS["GUT-BRAIN AXIS"]
    CD200 -->|"regulates"| GUT_BRAIN_AXIS
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"activates"| CD200
    MICROGLIA_ACTIVATION["MICROGLIA ACTIVATION"]
    MICROGLIA_ACTIVATION -->|"activates"| CD200
    PHAGOCYTOSIS["PHAGOCYTOSIS"]
    PHAGOCYTOSIS -->|"activates"| CD200
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"activates"| CD200
    GENES["GENES"]
    GENES -->|"associated with"| CD200
    TGFB1["TGFB1"]
    TGFB1 -->|"associated with"| CD200
    IL10["IL10"]
    IL10 -->|"associated with"| CD200
    CD200R1["CD200R1"]
    CD200R1 -->|"associated with"| CD200
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"regulates"| CD200
    Microglia["Microglia"]
    CD200 -->|"expressed in"| Microglia
    Hippocampus["Hippocampus"]
    CD200 -->|"expressed in"| Hippocampus
    neurodegeneration["neurodegeneration"]
    CD200 -->|"implicated in"| neurodegeneration

Outgoing (40)

Target	Relation	Type	Str
Neurodegeneration	activates	disease	0.65
ALS	activates	disease	0.65
Inflammation	activates	disease	0.65
Diabetes	regulates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
CD200R1	associated_with	gene	0.60
IL10	associated_with	gene	0.60
TGFB1	associated_with	gene	0.60
MRC1	associated_with	gene	0.60
IL4	associated_with	gene	0.60
Rb	therapeutic_target	protein	0.60
phagocytosis	activates	process	0.60
FGF2	inhibits	gene	0.60
FGF9	inhibits	gene	0.60
neuroinflammation	regulates	disease	0.60
CYTOKINES	therapeutic_target	gene	0.60
DIABETIC RETINOPATHY	activates	gene	0.60
AND	activates	gene	0.60
MICROGLIA	activates	gene	0.60
Phagocytosis	activates	pathway	0.60
Microglia Activation	activates	pathway	0.60
IL-4	associated_with	gene	0.60
AND	associated_with	gene	0.60
GUT-BRAIN AXIS	regulates	gene	0.60
INFLAMMATION	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
Cytokine	therapeutic_target	protein	0.60
Blood-Brain Barrier	inhibits	pathway	0.60
Endothelial	inhibits	cell_type	0.60
Ras	therapeutic_target	protein	0.60
microglia	expressed_in	cell_type	0.60
oligodendrocytes	expressed_in	cell_type	0.60
oxidative stress response	participates_in	pathway	0.60
Microglia	expressed_in	cell_type	0.55
Hippocampus	expressed_in	brain_region	0.55
MRC1	interacts_with	gene	0.50
DIABETES	regulates	disease	0.50
Retinopathy	regulates	disease	0.50
inflammation	activates	pathway	0.50
IL-4	interacts_with	concept	0.50

Incoming (20)

Source	Relation	Type	Str
TGFB1	associated_with	gene	0.60
IL10	associated_with	gene	0.60
CD200R1	associated_with	gene	0.60
IL4	associated_with	gene	0.60
MRC1	associated_with	gene	0.60
CD200R1	inhibits	gene	0.60
NEURODEGENERATION	activates	gene	0.60
MICROGLIA ACTIVATION	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
GENES	associated_with	gene	0.60
CYTOKINES	regulates	gene	0.60
MICROGLIA	activates	gene	0.60
DIABETIC RETINOPATHY	activates	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
TGFB1	interacts_with	gene	0.50
CD200R1	interacts_with	gene	0.50
IL10	interacts_with	gene	0.50
microglia	regulates	cell_type	0.50
microglia	activates	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CD200

Understanding Entity Pages

Summary

Wiki Pages (19)

CD200 Gene

neuroinflammation

CD200R1 Gene

Section 106: Gene Therapy Vectors in CBS/PSP

Microglial Polarization

Neuroprotective Microglia

CD200R1-Protein

CD200 Protein

il34-protein

Neuroimmune Interface Pathway

Section 147 Neuroimmune Interface and Glial-Neuronal Crosstalk Therapy in CBS/PSP

Microglia Modulation Therapy for Neurodegeneration

Advanced Neuroimmune Interface and Glial-Neuronal Crosstalk Therapy in CBS/PSP

Microglial Priming and Innate Immune Tolerance Therapy for Neurodegeneration

Nigral Microglia in Parkinson's Disease

Surveying Microglia

CD47 Protein