Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CDH23: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | CDH23 |
| Full Name | Cadherin 23 |
| Chromosome | 10q22.1 |
| Function | encodes a member of the cadherin superfamily of calcium-dependent cell adhesion molecules. |
| Primary Expression | photoreceptors: |
| Amino Acids | 654 aa |
| UniProt ID | Q9Y6M7 |
| NCBI Gene ID | 64061 |
| Ensembl ID | ENSG00000107736 |
| GeneCards | CDH23 |
| Human Protein Atlas | CDH23 |
| Protein Name | Cadherin-23 |
| Associated Diseases | ALS, Inflammation, Neuroinflammation, Ptsd |
| KG Connections | 35 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CDH23["<b>CDH23</b>"]
Als["Als"]
CDH23 -->|"associated with"| Als
Neuroinflammation["Neuroinflammation"]
CDH23 -->|"associated with"| Neuroinflammation
Alzheimer["Alzheimer"]
CDH23 -->|"therapeutic target"| Alzheimer
Aging["Aging"]
CDH23 -->|"therapeutic target"| Aging
Neuroinflammation["Neuroinflammation"]
CDH23 -->|"therapeutic target"| Neuroinflammation
ALS["ALS"]
CDH23 -->|"associated with"| ALS
Inflammation["Inflammation"]
CDH23 -->|"associated with"| Inflammation
GRM2["GRM2"]
CDH23 -->|"associated with"| GRM2
MITOCHONDRIA["MITOCHONDRIA"]
CDH23 -->|"associated with"| MITOCHONDRIA
HAPLN1["HAPLN1"]
CDH23 -->|"associated with"| HAPLN1
CCR5["CCR5"]
CDH23 -->|"associated with"| CCR5
P2RY12["P2RY12"]
CDH23 -->|"associated with"| P2RY12
AMYLOID["AMYLOID"]
CDH23 -->|"therapeutic target"| AMYLOID
APOPTOSIS["APOPTOSIS"]
CDH23 -->|"therapeutic target"| APOPTOSIS
ALZHEIMER["ALZHEIMER"]
CDH23 -->|"therapeutic target"| ALZHEIMER
AGING["AGING"]
CDH23 -->|"therapeutic target"| AGING
Oxidative_Stress["Oxidative Stress"]
CDH23 -->|"therapeutic target"| Oxidative_Stress
Apoptosis["Apoptosis"]
CDH23 -->|"therapeutic target"| Apoptosis
AND["AND"]
CDH23 -->|"associated with"| AND
Oxidative_Phosphorylation["Oxidative Phosphorylation"]
CDH23 -->|"associated with"| Oxidative_Phosphorylation
GENES["GENES"]
GENES -->|"associated with"| CDH23
NEUROINFLAMMATION["NEUROINFLAMMATION"]
NEUROINFLAMMATION -->|"associated with"| CDH23
P2RY12["P2RY12"]
P2RY12 -->|"associated with"| CDH23
CCR5["CCR5"]
CCR5 -->|"associated with"| CDH23
Amygdala["Amygdala"]
CDH23 -->|"expressed in"| Amygdala
Cortex["Cortex"]
CDH23 -->|"expressed in"| Cortex
Hippocampus["Hippocampus"]
CDH23 -->|"expressed in"| Hippocampus
Cerebellum["Cerebellum"]
CDH23 -->|"expressed in"| Cerebellum
neurodegeneration["neurodegeneration"]
CDH23 -->|"implicated in"| neurodegeneration| Target | Relation | Type | Str |
|---|---|---|---|
| Ptsd | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Neuroinflammation | associated_with | disease | 0.65 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| Aging | therapeutic_target | disease | 0.65 |
| Neuroinflammation | therapeutic_target | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| GRM2 | associated_with | gene | 0.60 |
| HAPLN1 | associated_with | gene | 0.60 |
| CCR5 | associated_with | gene | 0.60 |
| P2RY12 | associated_with | gene | 0.60 |
| MITOCHONDRIA | associated_with | gene | 0.60 |
| AMYLOID | therapeutic_target | gene | 0.60 |
| APOPTOSIS | therapeutic_target | gene | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
| AGING | therapeutic_target | gene | 0.60 |
| Oxidative Stress | therapeutic_target | pathway | 0.60 |
| Apoptosis | therapeutic_target | pathway | 0.60 |
| AND | associated_with | gene | 0.60 |
| Oxidative Phosphorylation | associated_with | pathway | 0.60 |
| Chemokine | associated_with | protein | 0.60 |
| Amygdala | expressed_in | brain_region | 0.55 |
| Cortex | expressed_in | brain_region | 0.55 |
| Hippocampus | expressed_in | brain_region | 0.55 |
| Cerebellum | expressed_in | brain_region | 0.55 |
| P2Y12 | associated_with | protein | 0.50 |
| GLUTAMATE | associated_with | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| P2RY12 | associated_with | gene | 0.60 |
| CCR5 | associated_with | gene | 0.60 |
| HAPLN1 | associated_with | gene | 0.60 |
| GRM2 | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| NEUROINFLAMMATION | associated_with | gene | 0.60 |
| MITOCHONDRIA | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||