CCL4

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCL4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

CCL4 (C-C motif chemokine ligand 4), also known as MIP-1β, is a CC chemokine that plays critical roles in neuroinflammation, microglial activation, and neurodegenerative processes in Alzheimer's disease, Parkinson's disease, and multiple sclerosis.

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flowchart TD
    CCL4["CCL4"] -->|"activates"| CCR5["CCR5"]
    CCL4["CCL4"] -->|"activates"| Inflammation["Inflammation"]
    CCL4["CCL4"] -->|"activates"| Ms["Ms"]
    CCL4["CCL4"] -->|"activates"| Fibrosis["Fibrosis"]
    CCL4["CCL4"] -->|"activates"| Huntington["Huntington"]
    CCL4["CCL4"] -->|"activates"| Tauopathy["Tauopathy"]
    CCL4["CCL4"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
    CCL4["CCL4"] -->|"associated with"| Fibrosis["Fibrosis"]
    CCL4["CCL4"] -->|"associated with"| Ms["Ms"]
    CCL4["CCL4"] -->|"associated with"| Inflammation["Inflammation"]
    CCL4["CCL4"] -->|"activates"| Autoimmune["Autoimmune"]
    CCL4["CCL4"] -->|"activates"| Als["Als"]
    style CCL4 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style CCR5 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Huntington fill:#ef5350,stroke:#333,color:#e0e0e0
    style Tauopathy fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
    style Autoimmune fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0