gene

NRXN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NRXN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

44Connections

0Hypotheses

0Analyses

28Outgoing

16Incoming

0Experiments

0Debates

Summary

Page for NRXN2 Gene

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🧬 Gene Info

Gene Symbol	NRXN2
Full Name	Neurexin 2
Chromosome	11q13.2
Function	encodes a presynaptic cell adhesion molecule essential for synaptic transmission.
Molecular Weight	180 kDa
UniProt ID	Q9UHG0
NCBI Gene ID	9379
Ensembl ID	Ensembl
GeneCards	NRXN2
Human Protein Atlas	NRXN2
Disease	Mechanism
Autism Spectrum Disorder	Mutations affect synaptic connectivity
Schizophrenia	Altered expression in brains
Alzheimer's Disease	Role in synaptic dysfunction
Approach	Status
Associated Diseases	ALS, Alzheimer
Interactions	NPTX2, NLGN1, CTSB, CTSD, NRXN3, NRXN1
KG Connections	44 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (17)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NRXN2["<b>NRXN2</b>"]
    Alzheimer["Alzheimer"]
    NRXN2 -->|"inhibits"| Alzheimer
    Dementia["Dementia"]
    NRXN2 -->|"inhibits"| Dementia
    Alzheimer["Alzheimer"]
    NRXN2 -->|"regulates"| Alzheimer
    Als["Als"]
    NRXN2 -->|"regulates"| Als
    ALS["ALS"]
    NRXN2 -->|"regulates"| ALS
    DEMENTIA["DEMENTIA"]
    NRXN2 -->|"inhibits"| DEMENTIA
    NPTX2["NPTX2"]
    NRXN2 -->|"interacts with"| NPTX2
    NLGN1["NLGN1"]
    NRXN2 -->|"interacts with"| NLGN1
    Neuron["Neuron"]
    NRXN2 -->|"interacts with"| Neuron
    NLGN1["NLGN1"]
    NRXN2 -->|"regulates"| NLGN1
    VGF["VGF"]
    NRXN2 -->|"regulates"| VGF
    SYNAPSE["SYNAPSE"]
    NRXN2 -->|"inhibits"| SYNAPSE
    CTSB["CTSB"]
    NRXN2 -->|"inhibits"| CTSB
    CTSD["CTSD"]
    NRXN2 -->|"inhibits"| CTSD
    ALZHEIMER["ALZHEIMER"]
    NRXN2 -->|"regulates"| ALZHEIMER
    AND["AND"]
    NRXN2 -->|"regulates"| AND
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    NRXN2 -->|"regulates"| ALZHEIMER_S_DISEASE
    NRXN3["NRXN3"]
    NRXN2 -->|"regulates"| NRXN3
    NRXN1["NRXN1"]
    NRXN2 -->|"regulates"| NRXN1
    EXOSOMES["EXOSOMES"]
    EXOSOMES -->|"inhibits"| NRXN2
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"inhibits"| NRXN2
    NRXN1["NRXN1"]
    NRXN1 -->|"regulates"| NRXN2
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"regulates"| NRXN2
    NRXN3["NRXN3"]
    NRXN3 -->|"regulates"| NRXN2
    AMYLOID["AMYLOID"]
    AMYLOID -->|"inhibits"| NRXN2
    CST3["CST3"]
    CST3 -->|"inhibits"| NRXN2
    CTSS["CTSS"]
    CTSS -->|"inhibits"| NRXN2
    NPTX1["NPTX1"]
    NPTX1 -->|"regulates"| NRXN2
    SERPINA3["SERPINA3"]
    SERPINA3 -->|"inhibits"| NRXN2
    GENES["GENES"]
    GENES -->|"regulates"| NRXN2

Outgoing (28)

Target	Relation	Type	Str
Alzheimer	inhibits	disease	0.65
Dementia	inhibits	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
ALS	regulates	disease	0.65
NPTX2	interacts_with	gene	0.60
NLGN1	interacts_with	gene	0.60
NLGN1	regulates	gene	0.60
VGF	regulates	gene	0.60
CTSB	inhibits	gene	0.60
CTSD	inhibits	gene	0.60
NRXN3	regulates	gene	0.60
NRXN1	regulates	gene	0.60
Presenilin	regulates	protein	0.60
DEMENTIA	inhibits	gene	0.60
Neuron	interacts_with	cell_type	0.60
SYNAPSE	inhibits	gene	0.60
ALZHEIMER	regulates	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
EXOSOMES	inhibits	gene	0.60
ALS	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
Cortex	expressed_in	brain_region	0.55
Hippocampus	expressed_in	brain_region	0.55
NRXN3	interacts_with	gene	0.50
NRXN1	interacts_with	protein	0.50
NRXN3	co_expressed_with	gene	0.50

Incoming (16)

Source	Relation	Type	Str
NRXN1	regulates	gene	0.60
NRXN3	regulates	gene	0.60
CST3	inhibits	gene	0.60
CTSS	inhibits	gene	0.60
NPTX1	regulates	gene	0.60
SERPINA3	inhibits	gene	0.60
NLGN1	regulates	gene	0.60
EXOSOMES	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
ALZHEIMER	regulates	gene	0.60
AMYLOID	inhibits	gene	0.60
GENES	regulates	gene	0.60
DEMENTIA	inhibits	gene	0.60
NLGN1	interacts_with	gene	0.55
NRXN1	interacts_with	gene	0.55
NRXN1	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

NRXN2

Understanding Entity Pages

Summary

Wiki Pages (17)

NRXN2 Gene

Synaptogenesis in Neurodegeneration

Neurexin/Neuroligin Synaptic Adhesion Modulator Therapy in Neurodegeneration

LRRTM2 Gene

NLGN3 Gene

CNTNAP4 Gene

NTNG2

Neurexin-1 Protein (NRXN1)

NLGN4Y Gene

NRXN2 Protein

NRXN3 Protein

NLGN2 Gene

NRXN3 Gene

Cerebellin-1 Protein

Neuroligin-1 Protein

Neurexin-1 Protein

LRRTM4 Protein