Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DCTN5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | DCTN5 |
| Full Name | DCTN5 |
| Chromosome | 16p12.2 |
| Protein Type | Gene |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | Spinal Cord |
| Pathways | Mitophagy, Alpha-Synuclein |
| NCBI Gene ID | Search NCBI |
| GeneCards | DCTN5 |
| Human Protein Atlas | DCTN5 |
| Associated Diseases | ALS, Neurodegeneration, Parkinson |
| Interactions | DCAF17, UBIQUITIN, PINK1, H2AX, P62, SNCA |
| KG Connections | 45 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
DCTN5["<b>DCTN5</b>"]
TREM2["TREM2"]
DCTN5 -->|"associated with"| TREM2
microglia["microglia"]
DCTN5 -->|"expressed in"| microglia
OxPC["OxPC"]
DCTN5 -->|"associated with"| OxPC
neurodegeneration["neurodegeneration"]
DCTN5 -->|"associated with"| neurodegeneration
STRRIDE["STRRIDE"]
DCTN5 -->|"associated with"| STRRIDE
DCTN5 -->|"implicated in"| neurodegeneration
style DCTN5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| TREM2 | associated_with | gene | 0.80 |
| OxPC | associated_with | chemical | 0.80 |
| microglia | expressed_in | cell_type | 0.80 |
| STRRIDE | associated_with | entity | 0.70 |
| Neurodegeneration | inhibits | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Parkinson | inhibits | disease | 0.65 |
| Parkinson | causes | disease | 0.65 |
| ALS | causes | disease | 0.65 |
| Neurodegeneration | causes | disease | 0.65 |
| DCAF17 | activates | gene | 0.60 |
| UBIQUITIN | inhibits | gene | 0.60 |
| PINK1 | inhibits | gene | 0.60 |
| H2AX | inhibits | gene | 0.60 |
| P62 | inhibits | gene | 0.60 |
| SNCA | activates | gene | 0.60 |
| DAPK1 | activates | gene | 0.60 |
| P62 | causes | gene | 0.60 |
| PARKINSON | inhibits | gene | 0.60 |
| Mitophagy | inhibits | pathway | 0.60 |
| PARKINSON'S DISEASE | causes | gene | 0.60 |
| ALPHA-SYNUCLEIN | causes | gene | 0.60 |
| Alpha-Synuclein | causes | pathway | 0.60 |
| Mitophagy | causes | pathway | 0.60 |
| Alpha-Synuclein | inhibits | protein | 0.60 |
| Ras | inhibits | protein | 0.60 |
| Spinal Cord | expressed_in | brain_region | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| DAPK1 | activates | gene | 0.60 |
| H2AX | causes | gene | 0.60 |
| DCAF17 | activates | gene | 0.60 |
| PINK1 | causes | gene | 0.60 |
| SNCA | activates | gene | 0.60 |
| UBIQUITIN | causes | gene | 0.60 |
| UBIQUITIN | inhibits | gene | 0.60 |
| P62 | inhibits | gene | 0.60 |
| H2AX | inhibits | gene | 0.60 |
| PINK1 | inhibits | gene | 0.60 |
| MITOPHAGY | inhibits | gene | 0.60 |
| NEURODEGENERATION | causes | gene | 0.60 |
| DNA | causes | gene | 0.60 |
| NEUROTOXICITY | causes | gene | 0.60 |
| PARKINSON | causes | gene | 0.60 |
| AND | activates | gene | 0.60 |
| MITOPHAGY | causes | gene | 0.60 |
| PARKINSON | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||