Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DLK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DLK2 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, expressed in, regulates. Associated with ALS, Als. Connected to 31 entities in the SciDEX knowledge graph.
| Gene Symbol | DLK2 |
| Full Name | Delta-Like Non-Canonical Notch Ligand 2 |
| Chromosome | 6p25.1 |
| Function | is a single-pass transmembrane protein that functions as a non-canonical Notch ligand. |
| Primary Expression | hematopoietic stem and progenitor cells - Adipose tissue: Regulated during adipogenesis - Liver and kidney: Moderate expression in parenchymal |
| Amino Acids | 387 aa |
| Exons | 8 |
| Pathways | Notch, Notch signaling |
| UniProt ID | Q9Y5F7 |
| NCBI Gene ID | 203522 |
| Ensembl ID | ENSG00000154640 |
| OMIM | 612651 |
| GeneCards | DLK2 |
| Human Protein Atlas | DLK2 |
| N-terminal extracellular domain | Contains multiple epidermal growth factor-like (EGF) repeats (typically 6-8) that mediate protein-protein interactions |
| Associated Diseases | neurodegeneration |
| Interactions | NOTCH1, GFAP, EGF, NESTIN, SOX2, VIMENTIN |
| KG Connections | 45 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
DLK2["<b>DLK2</b>"]
Als{"Als"}
DLK2 -->|"expressed in"| Als
DLK2 -->|"inhibits"| Als
ALS{"ALS"}
DLK2 -->|"expressed in"| ALS
Neurogenesis(["Neurogenesis"])
DLK2 -->|"expressed in"| Neurogenesis
Notch(["Notch"])
DLK2 -->|"inhibits"| Notch
ALDH1L1["ALDH1L1"]
DLK2 -->|"expressed in"| ALDH1L1
GENES["GENES"]
DLK2 -->|"inhibits"| GENES
NESTIN["NESTIN"]
DLK2 -->|"expressed in"| NESTIN
NOTCH1["NOTCH1"]
DLK2 -->|"inhibits"| NOTCH1
GFAP["GFAP"]
DLK2 -->|"inhibits"| GFAP
EGF["EGF"]
DLK2 -->|"inhibits"| EGF
DLK2 -->|"inhibits"| NESTIN
SOX2["SOX2"]
SOX2 -->|"inhibits"| DLK2
EGF -->|"expressed in"| DLK2
GFAP -->|"inhibits"| DLK2
NESTIN -->|"expressed in"| DLK2
ALDH1L1 -->|"expressed in"| DLK2
NOTCH1 -->|"inhibits"| DLK2
ALDH1L1 -->|"inhibits"| DLK2
VIMENTIN["VIMENTIN"]
VIMENTIN -->|"inhibits"| DLK2
ASTROCYTES["ASTROCYTES"]
ASTROCYTES -->|"inhibits"| DLK2
GENES -->|"inhibits"| DLK2
ASTROCYTE["ASTROCYTE"]
ASTROCYTE -->|"inhibits"| DLK2
GFAP -->|"regulates"| DLK2
style DLK2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Notch Signaling | involved_in | pathway | 0.85 |
| Notch Signaling Pathway | component_of | pathway | 0.75 |
| Als | expressed_in | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| ALS | expressed_in | disease | 0.65 |
| ALDH1L1 | expressed_in | gene | 0.60 |
| NESTIN | expressed_in | gene | 0.60 |
| NOTCH1 | inhibits | gene | 0.60 |
| GFAP | inhibits | gene | 0.60 |
| EGF | inhibits | gene | 0.60 |
| NESTIN | inhibits | gene | 0.60 |
| SOX2 | inhibits | gene | 0.60 |
| GFAP | expressed_in | entity | 0.60 |
| NOTCH1 | expressed_in | entity | 0.60 |
| SOX2 | expressed_in | entity | 0.60 |
| VIMENTIN | expressed_in | entity | 0.60 |
| EGF | expressed_in | gene | 0.60 |
| VIMENTIN | inhibits | gene | 0.60 |
| Neurogenesis | expressed_in | pathway | 0.60 |
| Notch | inhibits | pathway | 0.60 |
| GENES | inhibits | gene | 0.60 |
| Neurogenesis | inhibits | pathway | 0.60 |
| AND | inhibits | gene | 0.60 |
| ASTROCYTES | inhibits | gene | 0.60 |
| NOTCH | inhibits | gene | 0.60 |
| Astrocyte | inhibits | cell_type | 0.60 |
| ASTROCYTE | inhibits | gene | 0.60 |
| Entorhinal Cortex | expressed_in | brain_region | 0.55 |
| Hippocampus | expressed_in | brain_region | 0.55 |
| Cortex | expressed_in | brain_region | 0.55 |
| Astrocyte | expressed_in | cell_type | 0.55 |
| Astrocytes | inhibits | cell_type | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SOX2 | inhibits | gene | 0.60 |
| EGF | expressed_in | gene | 0.60 |
| GFAP | inhibits | gene | 0.60 |
| NESTIN | expressed_in | gene | 0.60 |
| ALDH1L1 | expressed_in | gene | 0.60 |
| NOTCH1 | inhibits | gene | 0.60 |
| ALDH1L1 | inhibits | gene | 0.60 |
| VIMENTIN | inhibits | gene | 0.60 |
| ASTROCYTES | inhibits | gene | 0.60 |
| GENES | inhibits | gene | 0.60 |
| ASTROCYTE | inhibits | gene | 0.60 |
| NOTCH | inhibits | gene | 0.60 |
| GFAP | regulates | protein | 0.56 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||