gene

DLK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DLK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

45Connections
0Hypotheses
0Analyses
32Outgoing
13Incoming

Summary

DLK2 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, expressed in, regulates. Associated with ALS, Als. Connected to 31 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolDLK2
Full NameDelta-Like Non-Canonical Notch Ligand 2
Chromosome6p25.1
Functionis a single-pass transmembrane protein that functions as a non-canonical Notch ligand.
Primary Expressionhematopoietic stem and progenitor cells - Adipose tissue: Regulated during adipogenesis - Liver and kidney: Moderate expression in parenchymal
Amino Acids387 aa
Exons8
PathwaysNotch, Notch signaling
UniProt IDQ9Y5F7
NCBI Gene ID203522
Ensembl IDENSG00000154640
OMIM612651
GeneCardsDLK2
Human Protein AtlasDLK2
N-terminal extracellular domainContains multiple epidermal growth factor-like (EGF) repeats (typically 6-8) that mediate protein-protein interactions
Associated Diseasesneurodegeneration
InteractionsNOTCH1, GFAP, EGF, NESTIN, SOX2, VIMENTIN
KG Connections45 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: DLK2 — AlphaFold Q9Y5F7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

DLK2 — Delta-Like Non-Canonical Notch Ligand 2

gene · 3673 words

NESTIN: Intermediate Filament Protein in Neural Stem Cells and Neurodegeneration

gene · 1827 words

NOTCH1 Gene

gene · 690 words

Genes

index · 271 words

Pathway Diagram

graph TD
    DLK2["<b>DLK2</b>"]
    Als{"Als"}
    DLK2 -->|"expressed in"| Als
    DLK2 -->|"inhibits"| Als
    ALS{"ALS"}
    DLK2 -->|"expressed in"| ALS
    Neurogenesis(["Neurogenesis"])
    DLK2 -->|"expressed in"| Neurogenesis
    Notch(["Notch"])
    DLK2 -->|"inhibits"| Notch
    ALDH1L1["ALDH1L1"]
    DLK2 -->|"expressed in"| ALDH1L1
    GENES["GENES"]
    DLK2 -->|"inhibits"| GENES
    NESTIN["NESTIN"]
    DLK2 -->|"expressed in"| NESTIN
    NOTCH1["NOTCH1"]
    DLK2 -->|"inhibits"| NOTCH1
    GFAP["GFAP"]
    DLK2 -->|"inhibits"| GFAP
    EGF["EGF"]
    DLK2 -->|"inhibits"| EGF
    DLK2 -->|"inhibits"| NESTIN
    SOX2["SOX2"]
    SOX2 -->|"inhibits"| DLK2
    EGF -->|"expressed in"| DLK2
    GFAP -->|"inhibits"| DLK2
    NESTIN -->|"expressed in"| DLK2
    ALDH1L1 -->|"expressed in"| DLK2
    NOTCH1 -->|"inhibits"| DLK2
    ALDH1L1 -->|"inhibits"| DLK2
    VIMENTIN["VIMENTIN"]
    VIMENTIN -->|"inhibits"| DLK2
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"inhibits"| DLK2
    GENES -->|"inhibits"| DLK2
    ASTROCYTE["ASTROCYTE"]
    ASTROCYTE -->|"inhibits"| DLK2
    GFAP -->|"regulates"| DLK2
    style DLK2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (32)

TargetRelationTypeStr
Notch Signalinginvolved_inpathway0.85
Notch Signaling Pathwaycomponent_ofpathway0.75
Alsexpressed_indisease0.65
Alsinhibitsdisease0.65
ALSexpressed_indisease0.65

Incoming (13)

SourceRelationTypeStr
SOX2inhibitsgene0.60
EGFexpressed_ingene0.60
GFAPinhibitsgene0.60
NESTINexpressed_ingene0.60
ALDH1L1expressed_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found