concept

ENTORHINAL CORTEX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ENTORHINAL CORTEX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

230Connections

1Hypotheses

3Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	ENTORHINAL CORTEX
Summary	Page for Entorhinal Cortex
Key Genes/Proteins	AMYLOID, TAU, HDAC3, P2RX7, APP
Related Diseases	ALZHEIMER'S DISEASE, AGING
Linked Hypotheses	8 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ENTORHINAL_CORTEX["ENTORHINAL CORTEX"]
    ENTORHINAL_CORTEX -->|"involved_in"| Spatial_Navigation["Spatial Navigation"]
    ENTORHINAL_CORTEX -->|"expressed in"| HIPPOCAMPUS["HIPPOCAMPUS"]
    ENTORHINAL_CORTEX -->|"inhibits"| MICROGLIA["MICROGLIA"]
    ENTORHINAL_CORTEX -->|"inhibits"| TAU["TAU"]
    ENTORHINAL_CORTEX -->|"interacts"| WHITE_MATTER["WHITE MATTER"]
    ENTORHINAL_CORTEX -->|"expressed in"| NEURON["NEURON"]
    Neurofibrillary_Tangles["Neurofibrillary Tangles"] -->|"expressed in"| ENTORHINAL_CORTEX
    Impaired_Neuronal_Activity["Impaired Neuronal Activity"] -->|"expressed in"| ENTORHINAL_CORTEX
    Cell_Death["Cell Death"] -->|"involved_in"| ENTORHINAL_CORTEX
    VIMENTIN["VIMENTIN"] -->|"expressed in"| ENTORHINAL_CORTEX
    ASTROCYTES["ASTROCYTES"] -->|"expressed in"| ENTORHINAL_CORTEX
    NESTIN["NESTIN"] -->|"expressed in"| ENTORHINAL_CORTEX
    SOX2["SOX2"] -->|"expressed in"| ENTORHINAL_CORTEX
    GENES["GENES"] -->|"expressed in"| ENTORHINAL_CORTEX

Outgoing (64)

Target	Relation	Type	Str
P2RX7	inhibits	gene	0.65
HIPPOCAMPUS	expressed_in	brain_region	0.50
MICROGLIA	inhibits	cell_type	0.50
TAU	inhibits	protein	0.50
NEURON	associated_with	cell_type	0.50
SYNAPTIC LOSS	associated_with	phenotype	0.50
CELL SURVIVAL	associated_with	phenotype	0.50
AMYLOID-BETA	associated_with	protein	0.50
P-TAU	associated_with	protein	0.50
OXIDATIVE STRESS	associated_with	phenotype	0.50
IDH2	associated_with	gene	0.50
ROS	associated_with	phenotype	0.50
PSEN1	associated_with	gene	0.50
AQP4	associated_with	gene	0.50
HDAC3	associated_with	gene	0.50
CERAMIDE	associated_with	phenotype	0.50
LRP1	associated_with	gene	0.50
PHOSPHO-TAU	associated_with	protein	0.50
EXCITOTOXICITY	associated_with	phenotype	0.50
PRION	associated_with	protein	0.50
SIRT3	associated_with	gene	0.50
MITOPHAGY	associated_with	phenotype	0.50
PINK1	associated_with	gene	0.50
TREM2	associated_with	gene	0.50
GRANULE CELLS	associated_with	cell_type	0.50
MMSE	associated_with	biomarker	0.50
CSF	associated_with	phenotype	0.50
FDG-PET	associated_with	biomarker	0.50
AMYLOID PET	associated_with	biomarker	0.50
ASTROCYTE	associated_with	cell_type	0.45
GFAP	associated_with	gene	0.45
AMYLOID PLAQUES	associated_with	phenotype	0.45
P2RX7	associated_with	gene	0.45
WNT PATHWAY	associated_with	pathway	0.45
TDP-43	associated_with	gene	0.45
JNK	associated_with	gene	0.45
TAU	associated_with	protein	0.45
DEMENTIA	associated_with	disease	0.45
TFEB	associated_with	gene	0.45
SIRT1	associated_with	gene	0.45
PI3K	associated_with	gene	0.45
AKT	associated_with	gene	0.45
NEUROGENESIS	associated_with	phenotype	0.45
FUS	associated_with	gene	0.45
IBA1	associated_with	gene	0.45
WHITE MATTER	interacts_with	brain_region	0.35
NEURON	expressed_in	cell_type	0.35
TAU	expressed_in	protein	0.35
HIPPOCAMPUS	depletes	brain_region	0.35
NEURON	depletes	cell_type	0.35

Incoming (166)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
AMYLOID	associated_with	protein	0.90
TAU	regulates	protein	0.70
AGING	stabilizes	phenotype	0.70
TAU	stabilizes	protein	0.70
HDAC3	inhibits	gene	0.70
NEURONS	causes	cell_type	0.70
MICROGLIA	associated_with	cell_type	0.66
APP	treats	gene	0.65
CORTEX	treats	brain_region	0.65
ASTROCYTE	inhibits	cell_type	0.65
CA1	inhibits	brain_region	0.65
TAU	interacts_with	protein	0.65
TAU	phosphorylates	protein	0.65
TAU	causes	protein	0.65
TAU	recruits	protein	0.65
NEURON	depleted_in	cell_type	0.60
FDG-PET	stabilizes	biomarker	0.60
FDG-PET	treats	biomarker	0.60
APP	inhibits	gene	0.58
ASTROCYTES	inhibits	cell_type	0.58
TAU	associated_with	protein	0.56
MICROGLIA	inhibits	cell_type	0.56
NEURONS	participates_in	cell_type	0.55
APP	implicated_in	gene	0.55
APP	participates_in	gene	0.55
AMYLOID	expressed_in	protein	0.50
ALZHEIMER'S DISEASE	implicated_in	disease	0.50
aldh1l1	expressed_in	gene	0.50
GFAP	expressed_in	gene	0.50
Astrocytes	expressed_in	cell_type	0.50
Astrocyte	expressed_in	cell_type	0.50
Cortex	expressed_in	brain_region	0.50
Hippocampus	expressed_in	entity	0.50
GENE EXPRESSION	expressed_in	concept	0.50
ALZHEIMER	associated_with	gene	0.50
Alzheimer'S Disease	associated_with	disease	0.50
Cortex	associated_with	brain_region	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
CELL DEATH	associated_with	concept	0.50
NEUROFIBRILLARY TANGLES	associated_with	concept	0.50
Cortex	interacts_with	brain_region	0.50
White Matter	interacts_with	process	0.50
CEREBELLUM	associated_with	concept	0.50
FRONTAL	associated_with	concept	0.50
Hippocampus	associated_with	entity	0.50
NEURONS	associated_with	concept	0.50
Neuroinflammation	associated_with	process	0.50
Neurodegeneration	associated_with	disease	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.625	Alzheimer's disease	Circuit-level neural dynamics in neurode

Mentioning Analyses (3)

Scientific analyses that reference this entity