concept

NOTCH SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NOTCH SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

150Connections

0Hypotheses

0Analyses

28Outgoing

41Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	NOTCH SIGNALING
Key Genes/Proteins	LRP1, BIN1, APP, AMYLOID, PIEZO1
Related Diseases	CANCER, APOPTOSIS, CHEMORESISTANCE

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    NOTCH_SIGNALING["NOTCH SIGNALING"]
    NOTCH_SIGNALING -->|"inhibits"| Neurogenesis["Neurogenesis"]
    NOTCH_SIGNALING -->|"regulates"| Developing_Brain_Cell_Fate["Developing Brain Cell Fate"]
    NOTCH_SIGNALING -->|"mediates"| Lateral_Inhibition["Lateral Inhibition"]
    GFAP["GFAP"] -->|"regulates"| NOTCH_SIGNALING
    VIM["VIM"] -->|"regulates"| NOTCH_SIGNALING
    CK2["CK2"] -->|"regulates"| NOTCH_SIGNALING
    PP2A["PP2A"] -->|"regulates"| NOTCH_SIGNALING
    DLK2["DLK2"] -->|"involved_in"| NOTCH_SIGNALING
    SOX2["SOX2"] -->|"involved_in"| NOTCH_SIGNALING
    LRP1_Inhibition["LRP1 Inhibition"] -->|"inhibits"| NOTCH_SIGNALING
    VIMENTIN["VIMENTIN"] -->|"regulates"| NOTCH_SIGNALING

Outgoing (37)

Target	Relation	Type	Str
CANCER	causes	disease	0.65
APOPTOSIS	activates	phenotype	0.65
APOPTOSIS	regulates	phenotype	0.65
OLIGODENDROCYTE	regulates	cell_type	0.65
CANCER	stabilizes	disease	0.60
CHEMORESISTANCE	implicated_in	phenotype	0.55
AMYLOID	associated_with	protein	0.50
CANCER	associated_with	disease	0.45
TUMOR CELLS	associated_with	cell_type	0.45
LEUKEMIA	associated_with	disease	0.45
LRP1	associated_with	gene	0.45
ASTROCYTES	associated_with	cell_type	0.45
ASTROCYTE	associated_with	cell_type	0.45
GFAP	associated_with	gene	0.45
NEUROGENESIS	associated_with	phenotype	0.45
NOTCH1	associated_with	gene	0.45
UBIQUITIN	associated_with	protein	0.45
TBK1	associated_with	gene	0.45
PSEN1	associated_with	gene	0.45
APP	associated_with	gene	0.45
NEURONS	associated_with	cell_type	0.45
BIN1	associated_with	gene	0.45
AKT	associated_with	gene	0.45
VEGF	associated_with	gene	0.45
AGING	associated_with	phenotype	0.45
APOPTOSIS	associated_with	phenotype	0.45
PSEN2	associated_with	gene	0.45
OLIGODENDROCYTE	associated_with	cell_type	0.45

Incoming (113)

Source	Relation	Type	Str
LRP1	causes	gene	0.65
LRP1	inhibits	gene	0.65
BIN1	regulates	gene	0.65
APP	degrades	gene	0.65
NEURONS	targets	cell_type	0.65
AMYLOID	stabilizes	protein	0.60
PIEZO1	activates	gene	0.55
PIEZO1	regulates	gene	0.55
LRP1	modifies	gene	0.55
LRP1	involved_in	gene	0.55
GFAP	expression	gene	0.55
SYNCRIP	involved_in	gene	0.55
HSPG2	regulates	gene	0.55
HSPG2	neurotoxic	gene	0.55
ANGPT1	involved_in	gene	0.55
CLDN1	inhibits	gene	0.55
AQP1	has_variant	gene	0.55
TET2	has_variant	gene	0.55
CHEMORESISTANCE	associated_with	phenotype	0.45
ENDOTHELIAL CELLS	associated_with	cell_type	0.45
TUMOR MICROENVIRONMENT	associated_with	phenotype	0.45
GLIAL FIBRILLARY ACIDIC PROTEIN	associated_with	biomarker	0.45
ALZHEIMER'S DISEASE	associated_with	disease	0.45
NEURODEGENERATION	associated_with	disease	0.45
LEUKEMIA	inhibits	disease	0.35
ASTROCYTES	regulates	cell_type	0.35
ASTROCYTES	inhibits	cell_type	0.35
GFAP	inhibits	gene	0.35
NOTCH	regulates	gene	0.35
ASTROCYTES	expressed_in	cell_type	0.35
NOTCH	expressed_in	gene	0.35
GFAP	expressed_in	gene	0.35
CANCER	therapeutic_target	disease	0.35
NOTCH	interacts_with	gene	0.35
CANCER	inhibits	disease	0.35
CANCER	activates	disease	0.35
CANCER	regulates	disease	0.35
ENDOTHELIAL CELLS	inhibits	cell_type	0.35
ENDOTHELIAL CELLS	regulates	cell_type	0.35
NOTCH	implicated_in	gene	0.35
FRONTOTEMPORAL DEMENTIA	implicated_in	disease	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NOTCH SIGNALING

Understanding Entity Pages

Wiki Pages (20)

HNRNPA2B1 Protein

Oligodendrocytes

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

Niemann-Pick Disease Type C (NPC)

PEN2 Gene

IGF-1 Signaling Pathway in Neurodegeneration

Notch Signaling Pathway in Neurodegeneration

FGF10 — Fibroblast Growth Factor 10

Neurogenesis

DLK2 — Delta-Like Non-Canonical Notch Ligand 2

genetics

Meningeal Lymphatics

KRIT1 — Krev Interaction Trapped 1 (CCM1)

Neurogenesis and Neurodegeneration

PSEN2 — Presenilin 2

Remyelination in Neurodegeneration

KDM3A Gene (JMJD1A)

Gamma-Secretase Complex (γ-Secretase)