concept

DAM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DAM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

9Hypotheses

30Analyses

15Outgoing

11Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	DAM
Summary	Page for Disease-Associated Microglia (DAM)
Key Genes/Proteins	TREM2, SYK, AMYLOID
Related Diseases	Alzheimer's Disease, NEURODEGENERATION, ALZHEIMERS
Linked Hypotheses	11 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DAM["DAM"]
    DAM -->|"component_of"| Microglia["Microglia"]
    DAM -->|"interacts"| Amyloid_Beta["Amyloid Beta"]
    DAM -.protects against.-> Neurodegeneration["Neurodegeneration"]
    DAM -->|"involved_in"| Phagocytosis["Phagocytosis"]
    DAM -->|"involved_in"| Alzheimer_s_Disease["Alzheimer's Disease"]
    DAM -->|"mediates"| Amyloid_Beta_Phagocytosis["Amyloid-Beta Phagocytosis"]
    DAM -->|"expressed in"| CNS["CNS"]
    TREM2["TREM2"] -->|"activates"| DAM

Outgoing (20)

Target	Relation	Type	Str
Alzheimer's Disease	associated_with	disease	0.95
Phagocytosis	involved_in	process	0.90
microglia	associated_with	cell_type	0.85
Neurodegeneration	protects_against	process	0.85
Alzheimer's Disease	involved_in	disease	0.85
Amyloid-Beta Phagocytosis	mediates	process	0.80
NEURODEGENERATION	associated_with	phenotype	0.72
ALZHEIMERS	associated_with	disease	0.72
CNS	expressed_in	brain_region	0.68
SYK	interacts_with	gene	0.65
SYK	activates	gene	0.65
AMYLOID	causes	protein	0.65
TREM2	causes	gene	0.65
TREM2	regulates	gene	0.65
APOE	interacts_with	gene	0.64

Incoming (11)

Source	Relation	Type	Str
TREM2	activates	protein	0.87
APOE	activates	gene	0.65
ASTROCYTES	treats	cell_type	0.65
NEUROINFLAMMATION	causes	phenotype	0.65
MICROGLIA	interacts_with	cell_type	0.65
MITOPHAGY	protects_against	phenotype	0.65
FRONTAL CORTEX	associated_with	brain_region	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
CORTEX	associated_with	brain_region	0.45
VORINOSTAT	associated_with	drug	0.45
NLRP3 INFLAMMASOME	associated_with	pathway	0.45

Targeting Hypotheses (9)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Multi-Target Hypothesis: Aβ-Induced Cholinergic Damage is Pa	0.700	-	Do β-amyloid plaques and neurofibrillary
Mitochondrial DAMPs-Driven AIM2 Inflammasome Activation in N	0.582	neurodegeneration	What are the mechanisms by which gut mic
PARP1 Inhibition Blocks Poly(PR)-Triggered DNA Damage and Su	0.562	neurodegeneration	What upstream mechanisms trigger p53 act
Cell-Type Specific TREM2 Upregulation in DAM Microglia	0.519	Alzheimer's Disease	SEA-AD Gene Expression Profiling — Allen
Microglial TREM2 downregulation impairs damage-associated re	0.507	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V

TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Functio	0.499	neuroinflammation	Why do TAM receptors protect against neu
DAMP-Scavenging Microglial Reset	0.462	-	Neuroinflammation and microglial priming
Stage-Selective TREM2 Agonism — Boosting DAM Phagocytosis in	0.458	Alzheimer's disease	TREM2 agonism vs antagonism in DAM micro
MITF Acts as the Primary Transcriptional Effector Downstream	0.444	neurodegeneration	How does HDAC1/2 deletion specifically e

Mentioning Analyses (30)

Scientific analyses that reference this entity

What are the cell-type-specific transcriptomic signatures of vulnerability in SE

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.576

How do synthetic EVs achieve brain-specific targeting while avoiding reticuloend

drug delivery | 2026-04-15 | 0 hypotheses

Are age-related static epigenetic patterns pathogenic or protective compensatory

epigenetics | 2026-04-15 | 0 hypotheses

Do CXCL10-recruited CD8+ T cells provide neuroprotection or cause damage in agin

neuroimmunology | 2026-04-15 | 1 hypotheses Top: 0.514

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.455

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797]	Zhou Y, Song WM, Andhey PS, Swain A, Lev	Nat Med	2020	1
Moderate Effects of the Arginine to Histidine R47H Variant of the Triggering Rec [PMID:41890852]	["Ramirez G", "Hernandez D", "Teal A", "	Research square	2026	0
Increased plasma soluble TREM2 levels in non-Alzheimer's dementia. [PMID:41920402]	Güven G, Gezegen H, Şahin E, Samancı B,	Acta neurologica Belgica	2026	0
AI-guided design of cyclic peptide binders targeting TREM2 using CycleRFdiffusio [PMID:41435973]	Cho S, Zhu R, Kuncewicz K, Duan H, Gabr	Bioorg Med Chem Lett	2026	0
ITAM-Syk signaling mediates the rebound phenomenon after anti-RANKL antibody dis [PMID:41490759]	Ishizu H, Hasegawa T, Shimizu T, Yamamot	Bone	2026	0
Oxaliplatin-artesunate conjugate intensifies suppression on colorectal cancer by [PMID:41520444]	Tan Y, Yang T, Jiang S, Li S, Cai L et a	J Inorg Biochem	2026	0
Diankuang Mengxing Decoction exerts neuroprotective effects in post-stroke depre [PMID:41534750]	Yang X, Zhao Y, Liu W, Feng J, Wu X et a	J Ethnopharmacol	2026	0
Loss of Triggering Receptor Expressed on Myeloid Cells 2 Impairs Microglial Func [PMID:41643896]	Chen G, Wang Z, Zhao C, Wang C, Li Y et	Am J Pathol	2026	0
Microglial metabolic reprogramming in Alzheimer's disease: Pathways, mechanisms, [PMID:41651180]	Yang FG, Yang H, Han SW, Wang JT, Gao W	Ageing Res Rev	2026	0
Plant-derived bioactive compounds modulate the gut microbiota in Alzheimer's dis [PMID:41678917]	Xue D, Hu X, Li R, Sun T, Qian S et al.	Phytomedicine	2026	0
Triggering Receptor Expressed on Myeloid Cells-2 Regulates Innate Lymphoid Cell [PMID:41928407]	Shen HC, Chen NJ, Sun CY, Yu WK, Su VY e	Kaohsiung J Med Sci	2026	0
TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604]	Yang HC, Deng YS, Zhang J, Zhang T, Song	J Alzheimers Dis	2026	0
Hierarchical Targeting of TREM2(+) Myeloid Cells via Acid-Triggered OMVs Reprogr [PMID:41945876]	Chen F, Xue Y, Ma X, Chen L, Shao Z et a	Adv Sci (Weinh)	2026	0
Correction to "A Strategy Involving Microporous Microneedles Integrated with CAR [PMID:41952643]	Unknown	Advanced materials (Deerfield	2026	0
Glycoursodeoxycholic acid regulates peritoneal monocytic myeloid-derived suppres [PMID:41955910]	Wang R, Wang B, Li B, Zhang J, Li Y et a	J Autoimmun	2026	0
A scalable human-zebrafish xenotransplantation model reveals gastrosome-mediated [PMID:41957412]	Villani A, Wittmann J, Wyss T, Mallona I	Commun Biol	2026	0
Dual Role of Microglial TREM2 in Neuronal Degeneration and Regeneration After Ax [PMID:41963086]	Pottorf TS, Lane EL, Haley-Johnson Z, Uk	J Neurosci	2026	0
TREM2-mediated microglial phagocytosis of inhibitory synapses contributes to pro [PMID:41965330]	Wang X, Zhou H, Zhai Y, Zhang Y, Cheng Y	Cell Death Discov	2026	0
Population-scale burden analysis of rare damaging coding variants identifies nov [PMID:41867223]	Le Guen Y, Peña-Tauber A, Pulgrossi RC,	medRxiv : the preprint server	2026	0
TREM2 as a possible link between Alzheimer's disease and diabetes mellitus. [PMID:41862118]	Chen W, Huang N, Huang W, Wang M, Luo Y,	Experimental neurology	2026	0

DAM

Understanding Entity Pages

Wiki Pages (21)

Disease-Associated Microglia (DAM)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

neuroinflammation

Alzheimer's Disease

Microglial Cells — Cell Type Hierarchy

TREM2 Mechanism Hub

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Oligodendrocytes

TREM2 Microglial Signaling Pathway in Neurodegeneration

AI and Machine Learning in Neurodegeneration

substantia-nigra

Epigenetic Alterations in Alzheimer's Disease

Charité - Universitätsmedizin Berlin

Traumatic Brain Injury and Neurodegeneration Pathway

Glia-Neuron Crosstalk in Alzheimer's Disease

Neuroprotection Strategies in Neurodegeneration

Experiment Prioritization Index — Neurodegeneration

Microglial Senescence Pathway in Neurodegeneration

Nanomedicine Approaches to Alzheimer's Disease

Pathway Diagram

Outgoing (20)

Incoming (11)

Targeting Hypotheses (9)

Mentioning Analyses (30)

What are the cell-type-specific transcriptomic signatures of vulnerability in SE

How do synthetic EVs achieve brain-specific targeting while avoiding reticuloend

Are age-related static epigenetic patterns pathogenic or protective compensatory

Do CXCL10-recruited CD8+ T cells provide neuroprotection or cause damage in agin

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

What molecular mechanisms cause iPLA2β deficiency to specifically damage mitocho

Does clusterin exacerbate or protect against neuronal death in neurodegeneration

How does APOE4's beneficial immune function reconcile with its established role

Why does the V1613M variant reduce amyloid pathology when ABCA7 loss-of-function

Why do TAM receptors protect against neuroinvasive viruses despite their known i

Why do TAM receptors protect against neuroinvasive viruses despite their known i

What is the molecular mechanism by which oligodendroglial MCT1 disruption causes

Do astrocytes functionally express TRIM46, and can PKCα phosphorylate it to driv

How can functional hyperconnectivity patterns distinguish compensatory mechanism

Do β-amyloid plaques and neurofibrillary tangles cause or result from cholinergi

Does DNAJB6 directly inhibit cross-seeding between tau, α-synuclein, and TDP-43

What is the actual quantitative contribution of FcRn-mediated transcytosis to BB

Is C1q elevation in AD pathogenic or compensatory for amyloid clearance?

What are the molecular signatures that distinguish protective vs. harmful microg

How can circuit-level neurodegeneration mechanisms be identified without complet

Can P16INK4A expression reliably distinguish harmful from beneficial senescent m

Do tau aggregates represent protective responses or primary pathogenic drivers i

Is myelin loss in AD causal or an adaptive response to neuronal damage?

Which neural cell types exhibit the most pronounced gene expression alterations

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or c

Do transferred mitochondria from diseased astrocytes carry pathological damage t

Can pathological vs physiological C1q tagging be distinguished at the molecular

Do chronic stress granule inhibition strategies impair normal cellular stress re

Does SYK activation provide neuroprotection or exacerbate neuroinflammation in e

Do SPM receptors undergo desensitization with chronic agonist treatment, prevent

Related Papers (20)