gene

TUFM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TUFM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

91Connections
0Hypotheses
0Analyses
50Outgoing
40Incoming

Summary

TUFM is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, activates. Associated with Als, Cancer, Tumor. Connected to 46 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolTUFM
AliasesEF-Tu, mtEF-Tu, EFTU
Chromosome16p11.2
Protein TypeTranslation elongation factor, GTP-binding protein
PathwaysInnate Immunity, Mitophagy
UniProt IDP49411
NCBI Gene ID7284
Ensembl IDENSG00000178952
OMIM609377
GeneCardsTUFM
Human Protein AtlasTUFM
Gene NameTu Translation Elongation Factor, Mitochondrial
Protein ClassTranslation elongation factor, GTP-binding protein
TissueExpression Level
HeartVery high
Associated Diseasesneurodegeneration
InteractionsLC3, TOMM40, AUTOPHAGY, MITOCHONDRIA, AND, APOPTOSIS
KG Connections91 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: TUFM — AlphaFold P49411 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

TUFM Gene

gene · 2437 words

FANCA Gene

gene · 2115 words

DARS2 Protein

protein · 1185 words

TOMM40 Gene

gene · 720 words

TYW5 Gene

gene · 678 words

Genes

index · 271 words

Pathway Diagram

graph TD
    TUFM["<b>TUFM</b>"]
    Als{"Als"}
    TUFM -->|"interacts with"| Als
    Cancer{"Cancer"}
    TUFM -->|"interacts with"| Cancer
    Tumor{"Tumor"}
    TUFM -->|"interacts with"| Tumor
    ULK1["ULK1"]
    TUFM -->|"associated with"| ULK1
    TRAF2["TRAF2"]
    TUFM -->|"associated with"| TRAF2
    DNM1L["DNM1L"]
    TUFM -->|"associated with"| DNM1L
    NLRP3["NLRP3"]
    TUFM -->|"associated with"| NLRP3
    Autophagy(["Autophagy"])
    TUFM -->|"associated with"| Autophagy
    Mitophagy(["Mitophagy"])
    TUFM -->|"activates"| Mitophagy
    Immune_Response(["Immune Response"])
    TUFM -->|"activates"| Immune_Response
    AUTOPHAGY["AUTOPHAGY"]
    TUFM -->|"activates"| AUTOPHAGY
    LC3["LC3"]
    TUFM -->|"interacts with"| LC3
    BCL2["BCL2"]
    BCL2 -->|"associated with"| TUFM
    FUNDC1["FUNDC1"]
    FUNDC1 -->|"associated with"| TUFM
    PARKIN["PARKIN"]
    PARKIN -->|"associated with"| TUFM
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"associated with"| TUFM
    TNF["TNF"]
    TNF -->|"associated with"| TUFM
    FIS1["FIS1"]
    FIS1 -->|"associated with"| TUFM
    AUTOPHAGY -->|"associated with"| TUFM
    SNAP29["SNAP29"]
    SNAP29 -->|"associated with"| TUFM
    LC3 -->|"associated with"| TUFM
    BCL2L13["BCL2L13"]
    BCL2L13 -->|"associated with"| TUFM
    MFF["MFF"]
    MFF -->|"associated with"| TUFM
    PRKN["PRKN"]
    PRKN -->|"associated with"| TUFM
    style TUFM fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (51)

TargetRelationTypeStr
neuronal apoptosispromotesprocess0.80
Alsinteracts_withdisease0.65
Cancerinteracts_withdisease0.65
Tumorinteracts_withdisease0.65
Infectionactivatesdisease0.65

Incoming (40)

SourceRelationTypeStr
BCL2associated_withgene0.60
FUNDC1associated_withgene0.60
PARKINassociated_withgene0.60
UBIQUITINassociated_withgene0.60
TNFassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found