gene

GAB2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GAB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections

0Hypotheses

0Analyses

25Outgoing

15Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	GAB2
Full Name	GRB2 Associated Binding Protein 2
Chromosome	11q14.1
Function	PI3K/AKT pathway amplification: Upon tyrosine phosphorylation, GAB2 recruits the p85 regulatory subunit of PI3K, leading to robust AKT activation.
Primary Expression	Brain (hippocampus, cortex), hematopoietic cells, mast cells
Molecular Weight	74 kDa
Amino Acids	676 aa
Exons	25
Pathways	PI3K, MAPK signaling
UniProt ID	Q9UQC2
NCBI Gene ID	9846
Ensembl ID	ENSG00000033327
OMIM	606203
GeneCards	GAB2
Human Protein Atlas	GAB2
Associated Diseases	Alzheimer
Interactions	CR1, MS4A6A, ABCA7, PICALM, MS4A4E, CLU
KG Connections	40 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GAB2 — AlphaFold Q9UQC2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GAB2["<b>GAB2</b>"]
    Alzheimer["Alzheimer"]
    GAB2 -->|"associated with"| Alzheimer
    CR1["CR1"]
    GAB2 -->|"interacts with"| CR1
    MS4A6A["MS4A6A"]
    GAB2 -->|"interacts with"| MS4A6A
    ABCA7["ABCA7"]
    GAB2 -->|"interacts with"| ABCA7
    PICALM["PICALM"]
    GAB2 -->|"interacts with"| PICALM
    ALZHEIMER["ALZHEIMER"]
    GAB2 -->|"associated with"| ALZHEIMER
    MS4A4E["MS4A4E"]
    GAB2 -->|"interacts with"| MS4A4E
    CLU["CLU"]
    GAB2 -->|"interacts with"| CLU
    APOE["APOE"]
    GAB2 -->|"interacts with"| APOE
    BIN1["BIN1"]
    GAB2 -->|"interacts with"| BIN1
    CD2AP["CD2AP"]
    GAB2 -->|"interacts with"| CD2AP
    TOMM40["TOMM40"]
    GAB2 -->|"interacts with"| TOMM40
    NME8["NME8"]
    GAB2 -->|"interacts with"| NME8
    MIRNAS["MIRNAS"]
    GAB2 -->|"associated with"| MIRNAS
    PTK2B["PTK2B"]
    GAB2 -->|"interacts with"| PTK2B
    AMYLOID["AMYLOID"]
    GAB2 -->|"associated with"| AMYLOID
    AND["AND"]
    GAB2 -->|"interacts with"| AND
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    GAB2 -->|"associated with"| ALZHEIMER_S_DISEASE
    GENES["GENES"]
    GAB2 -->|"interacts with"| GENES
    Amyloid["Amyloid"]
    GAB2 -->|"associated with"| Amyloid
    ZCWPW1["ZCWPW1"]
    ZCWPW1 -->|"interacts with"| GAB2
    PTK2B["PTK2B"]
    PTK2B -->|"interacts with"| GAB2
    CD2AP["CD2AP"]
    CD2AP -->|"interacts with"| GAB2
    APOE["APOE"]
    APOE -->|"interacts with"| GAB2
    CR1["CR1"]
    CR1 -->|"interacts with"| GAB2
    BIN1["BIN1"]
    BIN1 -->|"interacts with"| GAB2
    NME8["NME8"]
    NME8 -->|"interacts with"| GAB2
    ABCA7["ABCA7"]
    ABCA7 -->|"interacts with"| GAB2
    neurodegeneration["neurodegeneration"]
    GAB2 -->|"implicated in"| neurodegeneration

Outgoing (25)

Target	Relation	Type	Str
Alzheimer	associated_with	disease	0.65
CR1	interacts_with	gene	0.60
MS4A6A	interacts_with	gene	0.60
ABCA7	interacts_with	gene	0.60
PICALM	interacts_with	gene	0.60
MS4A4E	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
BIN1	interacts_with	gene	0.60
CD2AP	interacts_with	gene	0.60
TOMM40	interacts_with	gene	0.60
NME8	interacts_with	gene	0.60
PTK2B	interacts_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
MIRNAS	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
AND	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
GENES	interacts_with	gene	0.60
Amyloid	associated_with	pathway	0.60
App	associated_with	protein	0.60
ZCWPW1	interacts_with	gene	0.50
MS4A4E	co_mentioned	gene	0.40
PICALM	co_mentioned	gene	0.40
ZCWPW1	co_mentioned	gene	0.40

Incoming (15)

Source	Relation	Type	Str
ZCWPW1	interacts_with	gene	0.60
PTK2B	interacts_with	gene	0.60
CD2AP	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
CR1	interacts_with	gene	0.60
BIN1	interacts_with	gene	0.60
NME8	interacts_with	gene	0.60
ABCA7	interacts_with	gene	0.60
MS4A4E	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
BIN1	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
MIRNAS	associated_with	gene	0.60
APOE	co_mentioned	gene	0.40
CLU	co_mentioned	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GAB2

Understanding Entity Pages

Wiki Pages (7)

GAB2 — GRB2 Associated Binding Protein 2

PLCG2 Gene

GABRE Gene

GAB2 Protein

MS4A4E Gene - Membrane-Spanning 4-Domains A4E