protein

TOMM40

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TOMM40: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

90Connections

0Hypotheses

0Analyses

40Outgoing

50Incoming

Summary

TOMM40 is a protein involved in neurodegeneration research. Key relationships include: regulates, therapeutic target, implicated in. Associated with Inflammation, Osteoarthritis. Connected to 18 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	TOMM40
Full Name	Translocase of Outer Mitochondrial Membrane 40
Chromosome	19q13.32
Function	TOMM40 is the core component of the TOM complex, the primary gateway for protein import into mitochondria.
Molecular Weight	38 kDa
Pathways	Mitophagy
UniProt ID	Q9NTU5
NCBI Gene ID	219988
Ensembl ID	ENSG00000130254
OMIM	608633
GeneCards	TOMM40
Human Protein Atlas	TOMM40
Approach	Status
Mitochondrial Biogenesis Inducers	Research
Gene Therapy	Preclinical
Associated Diseases	Aging, Alzheimer
Interactions	NME8, PTK2B, MS4A6A, PICALM, ABCA7, CR1
KG Connections	90 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TOMM40 — AlphaFold Q9NTU5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (19)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TOMM40["TOMM40 Protein"]
    TOMM20["TOMM20"]
    Mitochondria["Mitochondrial Function"]
    Mitophagy_Path["Mitophagy Pathway"]
    ULK1["ULK1"]
    ATG12["ATG12"]
    LC3["LC3/MAP1LC3B"]
    Apoptosis_Path["Apoptosis Pathway"]
    Oxidative_Stress["Oxidative Stress"]
    Inflammation["Inflammation"]
    TBI["Traumatic Brain Injury"]
    UBB["Ubiquitin (UBB/UBC)"]
    CSNK2B["CSNK2B"]
    Neuroprotection["Neuroprotective Effects"]

    TOMM40 -->|"imports proteins"| Mitochondria
    TOMM20 -->|"cooperates with"| TOMM40
    TOMM40 -->|"regulates"| ULK1
    TOMM40 -->|"regulates"| ATG12
    ULK1 -->|"initiates"| Mitophagy_Path
    ATG12 -->|"promotes"| Mitophagy_Path
    LC3 -->|"regulates"| Mitophagy_Path
    Mitophagy_Path -->|"removes damaged"| Mitochondria
    TOMM40 -->|"can trigger"| Apoptosis_Path
    Oxidative_Stress -->|"damages"| TOMM40
    TOMM40 -->|"therapeutic target for"| Oxidative_Stress
    Inflammation -->|"affects"| TOMM40
    TOMM40 -->|"therapeutic target for"| Inflammation
    TBI -->|"dysregulates"| TOMM40
    UBB -->|"regulates stability"| TOMM40
    CSNK2B -->|"phosphorylates"| TOMM40
    Mitophagy_Path -->|"promotes"| Neuroprotection

    style TOMM40 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style Neuroprotection fill:#1b5e20,stroke:#2e7d32,stroke-width:2px
    style Mitophagy_Path fill:#1b5e20,stroke:#2e7d32,stroke-width:2px
    style ULK1 fill:#4a1a6b,stroke:#8e24aa,stroke-width:2px
    style ATG12 fill:#4a1a6b,stroke:#8e24aa,stroke-width:2px
    style LC3 fill:#4a1a6b,stroke:#8e24aa,stroke-width:2px
    style CSNK2B fill:#4a1a6b,stroke:#8e24aa,stroke-width:2px
    style Apoptosis_Path fill:#ef5350,stroke:#c62828,stroke-width:2px
    style Oxidative_Stress fill:#ef5350,stroke:#c62828,stroke-width:2px
    style TBI fill:#7d4200,stroke:#ef6c00,stroke-width:2px
    style Inflammation fill:#7d4200,stroke:#ef6c00,stroke-width:2px

Outgoing (40)

Target	Relation	Type	Str
Osteoarthritis	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Aging	associated_with	disease	0.65
ALS	regulates	disease	0.65
ATG12	regulates	gene	0.60
ULK1	regulates	gene	0.60
TUFM	inhibits	entity	0.60
NME8	interacts_with	gene	0.60
PTK2B	interacts_with	gene	0.60
MS4A6A	interacts_with	gene	0.60
PICALM	interacts_with	gene	0.60
ABCA7	interacts_with	gene	0.60
CR1	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
ZCWPW1	interacts_with	gene	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
Mitophagy	regulates	pathway	0.60
Apoptosis	activates	pathway	0.60
Mitophagy	activates	pathway	0.60
BRAIN INJURY	activates	gene	0.60
MITOCHONDRIA	inhibits	gene	0.60
MITOPHAGY	activates	gene	0.60
AND	inhibits	gene	0.60
APOPTOSIS	activates	gene	0.60
Neuron	activates	cell_type	0.60
MIRNAS	associated_with	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
Glutamate Signaling	associated_with	pathway	0.60
AND	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
Amyloid	associated_with	pathway	0.60
Ras	activates	protein	0.60
App	associated_with	protein	0.60
Neuron	expressed_in	cell_type	0.55
CD2AP	interacts_with	protein	0.50
disease	interacts_with	disease	0.50

Incoming (50)

Source	Relation	Type	Str
CSNK2B	regulates	gene	0.60
TOMM20	therapeutic_target	gene	0.60
UBB	regulates	gene	0.60
UBC	regulates	gene	0.60
LC3	regulates	gene	0.60
MAP1LC3B	regulates	gene	0.60
TUFM	inhibits	gene	0.60
ZCWPW1	interacts_with	gene	0.60
GAB2	interacts_with	gene	0.60
CR1	interacts_with	gene	0.60
MS4A6A	interacts_with	gene	0.60
ABCA7	interacts_with	gene	0.60
PICALM	interacts_with	gene	0.60
MS4A4E	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
BIN1	interacts_with	gene	0.60
CD2AP	interacts_with	gene	0.60
APOE	regulates	gene	0.60
APOE/TOMM40 LOCUS	regulates	gene	0.60
PTK2B	interacts_with	gene	0.60
NME8	interacts_with	gene	0.60
ABCA7	associated_with	gene	0.60
APOC1	associated_with	gene	0.60
APOE	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
CD2AP	associated_with	gene	0.60
CD33	associated_with	gene	0.60
CLU	associated_with	gene	0.60
CR1	associated_with	gene	0.60
EPHA1	associated_with	gene	0.60
MS4A6A	associated_with	gene	0.60
PICALM	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
TFAM	associated_with	gene	0.60
APOE	activates	gene	0.60
GFP	therapeutic_target	gene	0.60
MITOPHAGY	regulates	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
APOPTOSIS	activates	gene	0.60
AND	inhibits	gene	0.60
MITOPHAGY	activates	gene	0.60
MITOCHONDRIA	inhibits	gene	0.60
BRAIN INJURY	activates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
MIRNAS	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TOMM40

Understanding Entity Pages

Summary

Wiki Pages (19)

TOMM40 Gene

Mitophagy Pathway in Neurodegeneration

TOMM40L — Translocase of Outer Mitochondrial Membrane 40 Like

TIMM21 — Translocase of Inner Mitochondrial Membrane 21

TIMM9

TOMM20 — Translocase of Outer Mitochondrial Membrane 20

TOMM20 Protein

TOMM70

Parkin (PRKN) Neurons

TOMM40 Protein

CD33 (Siglec-3)

mitochondrial-dysfunction-ad

CSNK2B Gene

MS4A4E Gene - Membrane-Spanning 4-Domains A4E

TOMM22 — Translocase of Outer Mitochondrial Membrane 22

TOMM70 Protein

UBB — Ubiquitin B