gene

NME8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NME8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

73Connections
0Hypotheses
0Analyses
40Outgoing
33Incoming

Summary

NME8 Gene

View on Wiki →

🧬 Gene Info
Gene SymbolNME8
Protein TypeKinase
Functionencodes a protein with nucleoside diphosphate kinase (NDPK) activity and a thioredoxin domain
Primary Expressionthe retina and olfactory bulb, consistent with its role in ciliary function
UniProt IDQ9NPJ3
Ensembl IDENSG00000186919
GeneCardsNME8
Human Protein AtlasNME8
NDPK DomainNucleoside diphosphate kinase activity
Thioredoxin DomainOxidoreductase activity
Ciliary/Flagellar FunctionEssential for sperm motility and respiratory cilia
NDPK ActivityMaintains nucleotide pools for DNA/RNA synthesis
Thioredoxin ActivityAntioxidant function, maintaining cellular redox balance
Microtubule RegulationInvolved in microtubule organization
Protein Thiol-Disulfide OxidoreductaseCatalyzes disulfide bond formation/reduction
Associated DiseasesAls, Alzheimer, Ms
InteractionsPTK2B, ZCWPW1, ABCA7, GAB2, MS4A4E, CLU
KG Connections73 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: NME8 — AlphaFold Q9NPJ3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (10)

Knowledge base pages for this entity

Canonical Page

NME8 Gene

gene · 621 words

Sporadic vs Familial Alzheimer's Disease: Comprehensive Comparison

disease · 2800 words

GWAS Findings Hub: Alzheimer's and Parkinson's Disease

mechanism · 1349 words

NME8/NDPK8 Protein

protein · 884 words

CASS4 — Cas Scaffold Protein Family Member 4

gene · 768 words

CASS4 Protein

protein · 752 words

Pathway Diagram

graph TD
    NME8["NME8"]
    Ms{"Ms"}
    NME8 -->|"associated_with"| Ms
    Als{"Als"}
    NME8 -->|"associated_with"| Als
    Alzheimer{"Alzheimer"}
    NME8 -->|"associated_with"| Alzheimer
    ALZHEIMER["ALZHEIMER"]
    NME8 -->|"associated_with"| ALZHEIMER
    BIN1["BIN1"]
    NME8 -->|"associated_with"| BIN1
    CD2AP["CD2AP"]
    NME8 -->|"associated_with"| CD2AP
    INPP5D["INPP5D"]
    NME8 -->|"associated_with"| INPP5D
    EPHA1["EPHA1"]
    NME8 -->|"associated_with"| EPHA1
    CLU["CLU"]
    NME8 -->|"associated_with"| CLU
    CELF1["CELF1"]
    NME8 -->|"associated_with"| CELF1
    AND["AND"]
    NME8 -->|"associated_with"| AND
    GENES["GENES"]
    NME8 -->|"associated_with"| GENES
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    NME8 -->|"associated_with"| ALZHEIMER_S_DISEASE
    MEF2C["MEF2C"]
    NME8 -->|"associated_with"| MEF2C
    PTK2B["PTK2B"]
    NME8 -->|"associated_with"| PTK2B

Outgoing (40)

TargetRelationTypeStr
Msassociated_withdisease0.65
Alsassociated_withdisease0.65
Alzheimerassociated_withdisease0.65
BIN1associated_withgene0.60
CD2APassociated_withgene0.60

Incoming (33)

SourceRelationTypeStr
PLD3associated_withgene0.60
ABCA7associated_withgene0.60
SORL1associated_withgene0.60
PICALMassociated_withgene0.60
CR1associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found