Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MS4A4E: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | MS4A4E |
| Full Name | Membrane-Spanning 4-Domains A4E |
| Aliases | Page for MS4A4E Gene |
| Chromosome | 11q12.2 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | Brain, Spleen, Lymphocytes, Monocytes |
| UniProt ID | Q9NRL3 |
| NCBI Gene ID | 245722 |
| Ensembl ID | ENSG00000166908 |
| GeneCards | MS4A4E |
| Human Protein Atlas | MS4A4E |
| Associated Diseases | Alzheimer |
| Interactions | CLU, APOE, BIN1, CD2AP, TOMM40, NME8 |
| KG Connections | 41 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
MS4A4E["<b>MS4A4E</b>"]
Alzheimer["Alzheimer"]
MS4A4E -->|"associated with"| Alzheimer
CLU["CLU"]
MS4A4E -->|"interacts with"| CLU
APOE["APOE"]
MS4A4E -->|"interacts with"| APOE
BIN1["BIN1"]
MS4A4E -->|"interacts with"| BIN1
CD2AP["CD2AP"]
MS4A4E -->|"interacts with"| CD2AP
TOMM40["TOMM40"]
MS4A4E -->|"interacts with"| TOMM40
NME8["NME8"]
MS4A4E -->|"interacts with"| NME8
MIRNAS["MIRNAS"]
MS4A4E -->|"associated with"| MIRNAS
PTK2B["PTK2B"]
MS4A4E -->|"interacts with"| PTK2B
AND["AND"]
MS4A4E -->|"interacts with"| AND
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
MS4A4E -->|"associated with"| ALZHEIMER_S_DISEASE
GENES["GENES"]
MS4A4E -->|"interacts with"| GENES
ALZHEIMER["ALZHEIMER"]
MS4A4E -->|"associated with"| ALZHEIMER
MS4A6A["MS4A6A"]
MS4A4E -->|"interacts with"| MS4A6A
PICALM["PICALM"]
MS4A4E -->|"interacts with"| PICALM
Amyloid["Amyloid"]
MS4A4E -->|"associated with"| Amyloid
ZCWPW1["ZCWPW1"]
ZCWPW1 -->|"interacts with"| MS4A4E
GAB2["GAB2"]
GAB2 -->|"interacts with"| MS4A4E
CR1["CR1"]
CR1 -->|"interacts with"| MS4A4E
MS4A6A["MS4A6A"]
MS4A6A -->|"interacts with"| MS4A4E
ABCA7["ABCA7"]
ABCA7 -->|"interacts with"| MS4A4E
PICALM["PICALM"]
PICALM -->|"interacts with"| MS4A4E
ALZHEIMER["ALZHEIMER"]
ALZHEIMER -->|"associated with"| MS4A4E
PTK2B["PTK2B"]
PTK2B -->|"interacts with"| MS4A4E
CD2AP["CD2AP"]
CD2AP -->|"interacts with"| MS4A4E
APOE["APOE"]
APOE -->|"interacts with"| MS4A4E
BIN1["BIN1"]
BIN1 -->|"interacts with"| MS4A4E
NME8["NME8"]
NME8 -->|"interacts with"| MS4A4E
AMYLOID["AMYLOID"]
AMYLOID -->|"associated with"| MS4A4E
neurodegeneration["neurodegeneration"]
MS4A4E -->|"implicated in"| neurodegeneration| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | associated_with | disease | 0.65 |
| CLU | interacts_with | gene | 0.60 |
| APOE | interacts_with | gene | 0.60 |
| BIN1 | interacts_with | gene | 0.60 |
| CD2AP | interacts_with | gene | 0.60 |
| TOMM40 | interacts_with | gene | 0.60 |
| NME8 | interacts_with | gene | 0.60 |
| PTK2B | interacts_with | gene | 0.60 |
| MS4A6A | interacts_with | gene | 0.60 |
| PICALM | interacts_with | gene | 0.60 |
| GAB2 | interacts_with | gene | 0.60 |
| ABCA7 | interacts_with | gene | 0.60 |
| CR1 | interacts_with | gene | 0.60 |
| MIRNAS | associated_with | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| GENES | interacts_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| Amyloid | associated_with | pathway | 0.60 |
| App | associated_with | protein | 0.60 |
| ZCWPW1 | interacts_with | gene | 0.50 |
| PICALM | co_mentioned | gene | 0.40 |
| ZCWPW1 | co_mentioned | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ZCWPW1 | interacts_with | gene | 0.60 |
| GAB2 | interacts_with | gene | 0.60 |
| CR1 | interacts_with | gene | 0.60 |
| MS4A6A | interacts_with | gene | 0.60 |
| ABCA7 | interacts_with | gene | 0.60 |
| PICALM | interacts_with | gene | 0.60 |
| PTK2B | interacts_with | gene | 0.60 |
| CD2AP | interacts_with | gene | 0.60 |
| APOE | interacts_with | gene | 0.60 |
| BIN1 | interacts_with | gene | 0.60 |
| NME8 | interacts_with | gene | 0.60 |
| CLU | interacts_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| AMYLOID | associated_with | gene | 0.60 |
| MIRNAS | associated_with | gene | 0.60 |
| APOE | co_mentioned | gene | 0.40 |
| CLU | co_mentioned | gene | 0.40 |
| GAB2 | co_mentioned | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||