gene

MS4A4E

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MS4A4E: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections
0Hypotheses
0Analyses
23Outgoing
18Incoming

Summary

Page for MS4A4E Gene - Membrane-Spanning 4-Domains A4E

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🧬 Gene Info
Gene SymbolMS4A4E
Full NameMembrane-Spanning 4-Domains A4E
AliasesPage for MS4A4E Gene
Chromosome11q12.2
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionBrain, Spleen, Lymphocytes, Monocytes
UniProt IDQ9NRL3
NCBI Gene ID245722
Ensembl IDENSG00000166908
GeneCardsMS4A4E
Human Protein AtlasMS4A4E
Associated DiseasesAlzheimer
InteractionsCLU, APOE, BIN1, CD2AP, TOMM40, NME8
KG Connections41 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: MS4A4E — AlphaFold Q9NRL3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

MS4A4E Gene - Membrane-Spanning 4-Domains A4E

gene · 661 words

neuroinflammation

mechanism · 5462 words

Neuroinflammation Pathway

mechanisms · 3067 words

Sporadic vs Familial Alzheimer's Disease: Comprehensive Comparison

disease · 2800 words

EPHA1 Gene

gene · 2484 words

MS4A6A Gene

gene · 2260 words

Pathway Diagram

graph TD
    MS4A4E["<b>MS4A4E</b>"]
    Alzheimer["Alzheimer"]
    MS4A4E -->|"associated with"| Alzheimer
    CLU["CLU"]
    MS4A4E -->|"interacts with"| CLU
    APOE["APOE"]
    MS4A4E -->|"interacts with"| APOE
    BIN1["BIN1"]
    MS4A4E -->|"interacts with"| BIN1
    CD2AP["CD2AP"]
    MS4A4E -->|"interacts with"| CD2AP
    TOMM40["TOMM40"]
    MS4A4E -->|"interacts with"| TOMM40
    NME8["NME8"]
    MS4A4E -->|"interacts with"| NME8
    MIRNAS["MIRNAS"]
    MS4A4E -->|"associated with"| MIRNAS
    PTK2B["PTK2B"]
    MS4A4E -->|"interacts with"| PTK2B
    AND["AND"]
    MS4A4E -->|"interacts with"| AND
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    MS4A4E -->|"associated with"| ALZHEIMER_S_DISEASE
    GENES["GENES"]
    MS4A4E -->|"interacts with"| GENES
    ALZHEIMER["ALZHEIMER"]
    MS4A4E -->|"associated with"| ALZHEIMER
    MS4A6A["MS4A6A"]
    MS4A4E -->|"interacts with"| MS4A6A
    PICALM["PICALM"]
    MS4A4E -->|"interacts with"| PICALM
    Amyloid["Amyloid"]
    MS4A4E -->|"associated with"| Amyloid
    ZCWPW1["ZCWPW1"]
    ZCWPW1 -->|"interacts with"| MS4A4E
    GAB2["GAB2"]
    GAB2 -->|"interacts with"| MS4A4E
    CR1["CR1"]
    CR1 -->|"interacts with"| MS4A4E
    MS4A6A["MS4A6A"]
    MS4A6A -->|"interacts with"| MS4A4E
    ABCA7["ABCA7"]
    ABCA7 -->|"interacts with"| MS4A4E
    PICALM["PICALM"]
    PICALM -->|"interacts with"| MS4A4E
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"associated with"| MS4A4E
    PTK2B["PTK2B"]
    PTK2B -->|"interacts with"| MS4A4E
    CD2AP["CD2AP"]
    CD2AP -->|"interacts with"| MS4A4E
    APOE["APOE"]
    APOE -->|"interacts with"| MS4A4E
    BIN1["BIN1"]
    BIN1 -->|"interacts with"| MS4A4E
    NME8["NME8"]
    NME8 -->|"interacts with"| MS4A4E
    AMYLOID["AMYLOID"]
    AMYLOID -->|"associated with"| MS4A4E
    neurodegeneration["neurodegeneration"]
    MS4A4E -->|"implicated in"| neurodegeneration

Outgoing (23)

TargetRelationTypeStr
Alzheimerassociated_withdisease0.65
CLUinteracts_withgene0.60
APOEinteracts_withgene0.60
BIN1interacts_withgene0.60
CD2APinteracts_withgene0.60

Incoming (18)

SourceRelationTypeStr
ZCWPW1interacts_withgene0.60
GAB2interacts_withgene0.60
CR1interacts_withgene0.60
MS4A6Ainteracts_withgene0.60
ABCA7interacts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found