Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GABRB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GABRB1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, expressed in, biomarker for. Associated with Als, Autism, Ms. Connected to 12 entities in the SciDEX knowledge graph.
| Gene Symbol | GABRB1 |
| Full Name | GABA-A Receptor Subunit Beta 1 |
| Chromosome | 4p13 |
| Protein Type | Channel |
| Function | The GABA-A β1 subunit contributes to receptor function |
| Molecular Weight | 54 kDa |
| Amino Acids | 223 aa |
| UniProt ID | P18505 |
| NCBI Gene ID | 2565 |
| Ensembl ID | ENSG00000112739 |
| OMIM | 137192 |
| GeneCards | GABRB1 |
| Human Protein Atlas | GABRB1 |
| Associated Diseases | Ms, Schizophrenia |
| KG Connections | 15 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GABRB1["<b>GABRB1</b>"]
Als{"Als"}
GABRB1 -->|"biomarker for"| Als
Autism{"Autism"}
GABRB1 -->|"biomarker for"| Autism
Ms{"Ms"}
GABRB1 -->|"biomarker for"| Ms
GABRB1 -->|"associated with"| Ms
Schizophrenia{"Schizophrenia"}
GABRB1 -->|"associated with"| Schizophrenia
GABARAP["GABARAP"]
GABRB1 -->|"expressed in"| GABARAP
Toll_Like_Receptor(["Toll-Like Receptor"])
GABRB1 -->|"associated with"| Toll_Like_Receptor
neurodegeneration["neurodegeneration"]
GABRB1 -->|"implicated in"| neurodegeneration
GABARAPL1["GABARAPL1"]
GABARAPL1 -->|"expressed in"| GABRB1
GABARAP -->|"expressed in"| GABRB1
GRM5["GRM5"]
GRM5 -->|"associated with"| GABRB1
GABARAP -->|"associated with"| GABRB1
style GABRB1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Als | biomarker_for | disease | 0.65 |
| Autism | biomarker_for | disease | 0.65 |
| Ms | biomarker_for | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Schizophrenia | associated_with | disease | 0.65 |
| GABARAP | expressed_in | gene | 0.60 |
| Toll-Like Receptor | associated_with | pathway | 0.60 |
| benchmark_ot_ad_answer_key:GABRB1 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| GABARAPL1 | expressed_in | gene | 0.60 |
| GABARAP | expressed_in | gene | 0.60 |
| GRM5 | associated_with | gene | 0.60 |
| GABARAP | associated_with | gene | 0.60 |
| benchmark_ot_ad_answer_key:GABRB1 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||