gene

GABRB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABRB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections
0Hypotheses
0Analyses
9Outgoing
6Incoming

Summary

GABRB1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, expressed in, biomarker for. Associated with Als, Autism, Ms. Connected to 12 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolGABRB1
Full NameGABA-A Receptor Subunit Beta 1
Chromosome4p13
Protein TypeChannel
FunctionThe GABA-A β1 subunit contributes to receptor function
Molecular Weight54 kDa
Amino Acids223 aa
UniProt IDP18505
NCBI Gene ID2565
Ensembl IDENSG00000112739
OMIM137192
GeneCardsGABRB1
Human Protein AtlasGABRB1
Associated DiseasesMs, Schizophrenia
KG Connections15 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: GABRB1 — AlphaFold P18505 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

GABA-A Receptor Beta 1 Subunit

gene · 828 words

GRM5 Gene - Metabotropic Glutamate Receptor 5

gene · 1738 words

GABA-A Receptor Beta 1 Subunit

protein · 1107 words

mGluR5 (Metabotropic Glutamate Receptor 5)

protein · 1067 words

GABRE Protein (GABA-A Receptor Subunit Epsilon)

protein · 607 words

Proteins

index · 296 words

Pathway Diagram

graph TD
    GABRB1["<b>GABRB1</b>"]
    Als{"Als"}
    GABRB1 -->|"biomarker for"| Als
    Autism{"Autism"}
    GABRB1 -->|"biomarker for"| Autism
    Ms{"Ms"}
    GABRB1 -->|"biomarker for"| Ms
    GABRB1 -->|"associated with"| Ms
    Schizophrenia{"Schizophrenia"}
    GABRB1 -->|"associated with"| Schizophrenia
    GABARAP["GABARAP"]
    GABRB1 -->|"expressed in"| GABARAP
    Toll_Like_Receptor(["Toll-Like Receptor"])
    GABRB1 -->|"associated with"| Toll_Like_Receptor
    neurodegeneration["neurodegeneration"]
    GABRB1 -->|"implicated in"| neurodegeneration
    GABARAPL1["GABARAPL1"]
    GABARAPL1 -->|"expressed in"| GABRB1
    GABARAP -->|"expressed in"| GABRB1
    GRM5["GRM5"]
    GRM5 -->|"associated with"| GABRB1
    GABARAP -->|"associated with"| GABRB1
    style GABRB1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (9)

TargetRelationTypeStr
ds-83b31ef18d49provides_data_fordataset1.00
Alsbiomarker_fordisease0.65
Autismbiomarker_fordisease0.65
Msbiomarker_fordisease0.65
Msassociated_withdisease0.65

Incoming (6)

SourceRelationTypeStr
ds-83b31ef18d49data_indataset1.00
GABARAPL1expressed_ingene0.60
GABARAPexpressed_ingene0.60
GRM5associated_withgene0.60
GABARAPassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found