GADD34

Understanding Entity Pages

This page aggregates everything SciDEX knows about GADD34: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

GADD34 (Growth Arrest and DNA Damage Inducible Protein 34 / PPP1R15A) is a stress-induced gene that encodes a regulatory subunit of protein phosphatase 1, playing dual roles in stress recovery and apoptosis in neurodegeneration.

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graph TD
    GADD34["<b>GADD34</b>"]
    Als{"Als"}
    GADD34 -->|"activates"| Als
    XBP1["XBP1"]
    GADD34 -->|"activates"| XBP1
    Er_Stress(["Er Stress"])
    GADD34 -->|"activates"| Er_Stress
    Unfolded_Protein_Response(["Unfolded Protein Response"])
    GADD34 -->|"activates"| Unfolded_Protein_Response
    Apoptosis(["Apoptosis"])
    GADD34 -->|"activates"| Apoptosis
    neurodegeneration["neurodegeneration"]
    GADD34 -->|"implicated in"| neurodegeneration
    ATF4["ATF4"]
    ATF4 -->|"activates"| GADD34
    DDIT3["DDIT3"]
    DDIT3 -->|"activates"| GADD34
    GENES["GENES"]
    GENES -->|"activates"| GADD34
    ERN1["ERN1"]
    ERN1 -->|"activates"| GADD34
    TREM2["TREM2"]
    TREM2 -->|"activates"| GADD34
    ATF6["ATF6"]
    ATF6 -->|"activates"| GADD34
    style GADD34 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0