protein

HEATR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HEATR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections

0Hypotheses

0Analyses

22Outgoing

5Incoming

0Experiments

0Debates

Summary

Page for HEATR1 Protein

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🔬 Protein Info

Gene Symbol	HEATR1
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	neurons of the brain and spinal cord, where it supports ribosomal RNA processing and protein synthesis essential for neuronal sur
Subcellular Localization	the nucleolus, the site of ribosome biogenesis. Its HEAT repeat domains mediate protein-protein interactions essential f
Molecular Weight	299 kDa
Pathways	Apoptosis, Cell Cycle, Proteasome, apoptosis pathway, ubiquitin-proteasome
Ensembl ID	ENSG00000109118
GeneCards	HEATR1
Human Protein Atlas	HEATR1
Ribosomal Large Subunit Biogenesis	HEATR1 is essential for 60S ribosomal subunit maturation and export from the nucleus to the cytoplasm[@kress2013]
rRNA Processing	Required for proper processing of 18S rRNA precursor, the critical step in small ribosomal subunit formation[@tumialis2014]
Pre-rRNA Assembly	Associates with the 90S pre-ribosomal particle and participates in early processing steps
RNA Polymerase I Transcription	Facilitates transcription of ribosomal DNA by RNA polymerase I in the nucleolus
Cell Cycle Regulation	Necessary for cell cycle progression through its role in ribosome production
Brain	Cerebral cortex, hippocampus, basal ganglia, and cerebellum
Associated Diseases	Tumor
KG Connections	27 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HEATR1 Gene

gene · 641 words

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HEATR1 Protein

protein · 657 words

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Pathway Diagram

graph TD
    HEATR1["HEATR1"]
    Cancer{"Cancer"}
    HEATR1 -->|"expressed_in"| Cancer
    Aging{"Aging"}
    HEATR1 -->|"expressed_in"| Aging
    Tumor{"Tumor"}
    HEATR1 -->|"associated_with"| Tumor
    Carcinoma{"Carcinoma"}
    HEATR1 -->|"expressed_in"| Carcinoma
    DNA(["DNA"])
    HEATR1 -->|"expressed_in"| DNA
    RNA(["RNA"])
    HEATR1 -->|"expressed_in"| RNA
    APOPTOSIS(["APOPTOSIS"])
    APOPTOSIS -->|"associated_with"| HEATR1
    style HEATR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (22)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:HEATR1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Cancer	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Tumor	associated_with	disease	0.65
Carcinoma	expressed_in	disease	0.65
APOPTOSIS	associated_with	gene	0.60
CANCER	expressed_in	gene	0.60
DNA	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
Cell Cycle	associated_with	pathway	0.60
Proteasome	associated_with	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
Apoptosis	associated_with	pathway	0.60
Hepatocyte	expressed_in	cell_type	0.60
Ras	expressed_in	protein	0.60
cancer	expressed_in	disease	0.50
GENE EXPRESSION	expressed_in	concept	0.50
TUMOR	associated_with	disease	0.50
apoptosis	associated_with	process	0.50
CELL CYCLE	associated_with	cell_type	0.50

Incoming (5)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:HEATR1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
RNA	expressed_in	gene	0.60
DNA	expressed_in	gene	0.60
APOPTOSIS	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HEATR1 in their description or question text

No additional research found