Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HES5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
HES5 is a basic helix-loop-helix transcription factor, key effector of Notch signaling, involved in neural stem cell maintenance and neurogenesis
| Gene Symbol | HES5 |
| Full Name | Hairy and Enhancer of Split 5 |
| Chromosome | 1p36.32 |
| Protein Family | HES family (bHLH transcription factor) |
| Protein Type | Transcription Factor |
| Function | is a basic helix-loop-helix (bHLH) transcription factor that functions as a transcriptional repressor and serves as a key effector of the Notch signaling pathway. |
| Primary Expression | the ventricular and subventricular zones, where neural stem cells reside |
| Amino Acids | 199 aa |
| Pathways | Notch signaling, Notch |
| UniProt ID | [Q5JT76](https://www.uniprot.org/uniprot/Q5JT76) |
| Ensembl ID | ENSG00000197921 |
| OMIM | 604527 |
| GeneCards | HES5 |
| Human Protein Atlas | HES5 |
| Subventricular zone (SVZ) | Neural stem cells |
| Associated Diseases | neurodegeneration |
| Interactions | C-FOS, TNF-Α, NEUROINFLAMMATION, DEPRESSION, IFN, TNF |
| KG Connections | 24 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
HES5["<b>HES5</b>"]
Aging{"Aging"}
HES5 -->|"expressed in"| Aging
Ms{"Ms"}
HES5 -->|"expressed in"| Ms
SOX2["SOX2"]
HES5 -->|"expressed in"| SOX2
Epigenetic(["Epigenetic"])
HES5 -->|"expressed in"| Epigenetic
neurodegeneration["neurodegeneration"]
HES5 -->|"implicated in"| neurodegeneration
style HES5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Aging | expressed_in | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Parkinson | activates | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Neuroinflammation | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Depression | activates | disease | 0.65 |
| SOX2 | expressed_in | gene | 0.60 |
| HES1 | expressed_in | gene | 0.60 |
| Epigenetic | expressed_in | pathway | 0.60 |
| C-FOS | activates | gene | 0.60 |
| TNF-Α | activates | gene | 0.60 |
| NEUROINFLAMMATION | activates | gene | 0.60 |
| DEPRESSION | activates | gene | 0.60 |
| IFN | activates | gene | 0.60 |
| Notch | expressed_in | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||