HES1

Understanding Entity Pages

This page aggregates everything SciDEX knows about HES1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

HES1 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, expressed in. Associated with Aging, Als, Amyotrophic Lateral Sclerosis. Connected to 46 entities in the SciDEX knowledge graph.

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graph TD
    HES1["<b>HES1</b>"]
    Ischemia{"Ischemia"}
    HES1 -->|"activates"| Ischemia
    Als{"Als"}
    HES1 -->|"expressed in"| Als
    HES1 -->|"activates"| Als
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    HES1 -->|"activates"| Amyotrophic_Lateral_Sclerosis
    HES1 -->|"inhibits"| Als
    NESTIN["NESTIN"]
    HES1 -->|"activates"| NESTIN
    NOTCH1["NOTCH1"]
    HES1 -->|"expressed in"| NOTCH1
    GFAP["GFAP"]
    HES1 -->|"activates"| GFAP
    Neurogenesis(["Neurogenesis"])
    HES1 -->|"activates"| Neurogenesis
    Notch(["Notch"])
    HES1 -->|"expressed in"| Notch
    ASTROCYTES["ASTROCYTES"]
    HES1 -->|"activates"| ASTROCYTES
    SOD1["SOD1"]
    HES1 -->|"activates"| SOD1
    NGF["NGF"]
    NGF -->|"activates"| HES1
    DCX["DCX"]
    DCX -->|"activates"| HES1
    BDNF["BDNF"]
    BDNF -->|"activates"| HES1
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"activates"| HES1
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"activates"| HES1
    MOTOR_NEURONS["MOTOR NEURONS"]
    MOTOR_NEURONS -->|"activates"| HES1
    NESTIN -->|"inhibits"| HES1
    GFAP -->|"inhibits"| HES1
    style HES1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0