gene 1,775 words KG: JAG1 2026-03-27
kind:genesection:genesstate:published
Contents

JAG1 — Jagged 1

🧬 Gene Info
Gene SymbolJAG1
Full NameJagged 1 (Notch Ligand)
Chromosome20p12.2
Functionis a critical member of the Notch ligand family that plays essential roles in cell fate determination, embryonic development, tissue homeostasis, and increasingly recognized functions in neurodegen...
Primary ExpressionCerebral cortex, Cochlea, Liver, Heart
Molecular Weight~134 kDa
Amino Acids218 aa
PathwaysNotch, NOTCH, Notch signaling
UniProt IDP78504
NCBI Gene ID1950
Ensembl IDENSG00000101384
OMIM184756
GeneCardsJAG1
Human Protein AtlasJAG1
Protein Length1,218 amino acids
Associated DiseasesALS, neurodegeneration
InteractionsNOTCH1, ULK1, Rb, NOTCH, RNA, APOPTOSIS
KG Connections202 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (1)

Epigenetic Memory Reprogramming for Alzheimer's Disease
Score: 0.47

Related Analyses (2)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: inhibits
Packard Center for ALS Research
institution · KG edge: activates
DKK1 — Dickkopf WNT Signaling Pathway Inhibitor 1
gene · KG edge: therapeutic_target
CTNNB1 — Catenin Beta 1
gene · KG edge: therapeutic_target
CREBBP Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

JAG1 therapeutic_target MITF
JAG1 therapeutic_target GAIN
JAG1 therapeutic_target AXIN2
JAG1 therapeutic_target CD44
JAG1 therapeutic_target ALDH1A1
JAG1 therapeutic_target FGF18
JAG1 therapeutic_target ATF3
JAG1 therapeutic_target IL10
JAG1 therapeutic_target DKK1
JAG1 therapeutic_target PPARD