Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HSPH1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
HSPH1 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, activates, implicated in. Associated with Als, Cancer, Gastric Cancer. Connected to 37 entities in the SciDEX knowledge graph.
| Gene Symbol | HSPH1 |
| Full Name | Heat Shock Protein Family H (Hsp110) Member 1 |
| Chromosome | 14q21.3. |
| Function | Member 1), also known as Hsp105 or Hsp110, is a member of the Hsp110 family of heat shock proteins |
| Primary Expression | various cancers |
| Molecular Weight | 110 kDa |
| Pathways | Ferroptosis |
| UniProt ID | Q9Y617 |
| NCBI Gene ID | 10884 |
| Ensembl ID | ENSG00000120655 |
| OMIM | 607547 |
| GeneCards | HSPH1 |
| Human Protein Atlas | HSPH1 |
| Associated Diseases | neurodegeneration |
| Interactions | ATF2, FERROPTOSIS, CANCER, SLC7A11, DNAJA1, DNAJB1 |
| KG Connections | 56 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
HSPH1["<b>HSPH1</b>"]
Lymphoma{"Lymphoma"}
HSPH1 -->|"expressed in"| Lymphoma
Ms{"Ms"}
HSPH1 -->|"expressed in"| Ms
Cancer{"Cancer"}
HSPH1 -->|"expressed in"| Cancer
Tumor{"Tumor"}
HSPH1 -->|"expressed in"| Tumor
HSPA1L["HSPA1L"]
HSPH1 -->|"expressed in"| HSPA1L
HSPA1A["HSPA1A"]
HSPH1 -->|"expressed in"| HSPA1A
DNAJC10["DNAJC10"]
HSPH1 -->|"expressed in"| DNAJC10
Apoptosis(["Apoptosis"])
HSPH1 -->|"expressed in"| Apoptosis
Unfolded_Protein_Response(["Unfolded Protein Response"])
HSPH1 -->|"expressed in"| Unfolded_Protein_Response
Nf__b(["Nf-Kappab"])
HSPH1 -->|"expressed in"| Nf__b
Phagocytosis(["Phagocytosis"])
HSPH1 -->|"expressed in"| Phagocytosis
neurodegeneration["neurodegeneration"]
HSPH1 -->|"implicated in"| neurodegeneration
UBIQUITIN["UBIQUITIN"]
UBIQUITIN -->|"expressed in"| HSPH1
CANCER["CANCER"]
CANCER -->|"expressed in"| HSPH1
BAG3["BAG3"]
BAG3 -->|"expressed in"| HSPH1
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"expressed in"| HSPH1
UBC["UBC"]
UBC -->|"expressed in"| HSPH1
HSPD1["HSPD1"]
HSPD1 -->|"expressed in"| HSPH1
NF__B["NF-KappaB"]
NF__B -->|"expressed in"| HSPH1
DNAJC7["DNAJC7"]
DNAJC7 -->|"expressed in"| HSPH1
HSPA6["HSPA6"]
HSPA6 -->|"expressed in"| HSPH1
DNAJB1["DNAJB1"]
DNAJB1 -->|"expressed in"| HSPH1
IKBKB["IKBKB"]
IKBKB -->|"expressed in"| HSPH1
HSPA1B["HSPA1B"]
HSPA1B -->|"expressed in"| HSPH1
style HSPH1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Lymphoma | expressed_in | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Gastric Cancer | activates | disease | 0.65 |
| HSPA1L | expressed_in | gene | 0.60 |
| HSPA1A | expressed_in | gene | 0.60 |
| DNAJC10 | expressed_in | gene | 0.60 |
| ATF2 | activates | gene | 0.60 |
| HSP90AB1 | expressed_in | gene | 0.60 |
| IKBKB | expressed_in | gene | 0.60 |
| HSPE1 | expressed_in | gene | 0.60 |
| HSP60 | expressed_in | gene | 0.60 |
| DNAJB1 | expressed_in | gene | 0.60 |
| Apoptosis | expressed_in | pathway | 0.60 |
| Unfolded Protein Response | expressed_in | pathway | 0.60 |
| Nf-Κb | expressed_in | pathway | 0.60 |
| Phagocytosis | expressed_in | pathway | 0.60 |
| FERROPTOSIS | activates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| Ferroptosis | activates | pathway | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| UBIQUITIN | expressed_in | gene | 0.60 |
| BAG3 | expressed_in | gene | 0.60 |
| UBC | expressed_in | gene | 0.60 |
| HSPD1 | expressed_in | gene | 0.60 |
| DNAJC7 | expressed_in | gene | 0.60 |
| HSPA6 | expressed_in | gene | 0.60 |
| DNAJB1 | expressed_in | gene | 0.60 |
| IKBKB | expressed_in | gene | 0.60 |
| HSPA1B | expressed_in | gene | 0.60 |
| HSPE1 | expressed_in | gene | 0.60 |
| HSP90AB1 | expressed_in | gene | 0.60 |
| HSP70 | expressed_in | gene | 0.60 |
| SLC7A11 | activates | gene | 0.60 |
| HSPA1L | expressed_in | gene | 0.60 |
| DNAJC10 | expressed_in | gene | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| APOPTOSIS | expressed_in | gene | 0.60 |
| NF-ΚB | expressed_in | gene | 0.60 |
| PHAGOCYTOSIS | expressed_in | gene | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| DNAJA1 | activates | gene | 0.55 |
| DNAJB1 | activates | gene | 0.55 |
| HSP70 | activates | gene | 0.55 |
| HSPA1A | activates | gene | 0.55 |
| HSPA8 | activates | gene | 0.55 |
| DNAJB1 | interacts_with | gene | 0.55 |
| HSC70 | activates | gene | 0.55 |
| HSP110 | activates | gene | 0.55 |
| HSP40 | activates | gene | 0.55 |
| HSP40 | interacts_with | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||