gene

HSPH1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSPH1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

56Connections
0Hypotheses
0Analyses
25Outgoing
31Incoming

Summary

HSPH1 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, activates, implicated in. Associated with Als, Cancer, Gastric Cancer. Connected to 37 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolHSPH1
Full NameHeat Shock Protein Family H (Hsp110) Member 1
Chromosome14q21.3.
FunctionMember 1), also known as Hsp105 or Hsp110, is a member of the Hsp110 family of heat shock proteins
Primary Expressionvarious cancers
Molecular Weight110 kDa
PathwaysFerroptosis
UniProt IDQ9Y617
NCBI Gene ID10884
Ensembl IDENSG00000120655
OMIM607547
GeneCardsHSPH1
Human Protein AtlasHSPH1
Associated Diseasesneurodegeneration
InteractionsATF2, FERROPTOSIS, CANCER, SLC7A11, DNAJA1, DNAJB1
KG Connections56 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: HSPH1 — AlphaFold Q9Y617 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

HSPH1 Gene

gene · 737 words

Molecular Chaperones in Neurodegeneration

mechanism · 1736 words

HSPB2 Gene (Heat Shock Protein Family B Member 2)

gene · 1701 words

HSP70 (Heat Shock Protein 70 / HSPA1A)

protein · 1532 words

Hsp105 Protein

protein · 876 words

HSPA6

gene · 791 words

Pathway Diagram

graph TD
    HSPH1["<b>HSPH1</b>"]
    Lymphoma{"Lymphoma"}
    HSPH1 -->|"expressed in"| Lymphoma
    Ms{"Ms"}
    HSPH1 -->|"expressed in"| Ms
    Cancer{"Cancer"}
    HSPH1 -->|"expressed in"| Cancer
    Tumor{"Tumor"}
    HSPH1 -->|"expressed in"| Tumor
    HSPA1L["HSPA1L"]
    HSPH1 -->|"expressed in"| HSPA1L
    HSPA1A["HSPA1A"]
    HSPH1 -->|"expressed in"| HSPA1A
    DNAJC10["DNAJC10"]
    HSPH1 -->|"expressed in"| DNAJC10
    Apoptosis(["Apoptosis"])
    HSPH1 -->|"expressed in"| Apoptosis
    Unfolded_Protein_Response(["Unfolded Protein Response"])
    HSPH1 -->|"expressed in"| Unfolded_Protein_Response
    Nf__b(["Nf-Kappab"])
    HSPH1 -->|"expressed in"| Nf__b
    Phagocytosis(["Phagocytosis"])
    HSPH1 -->|"expressed in"| Phagocytosis
    neurodegeneration["neurodegeneration"]
    HSPH1 -->|"implicated in"| neurodegeneration
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"expressed in"| HSPH1
    CANCER["CANCER"]
    CANCER -->|"expressed in"| HSPH1
    BAG3["BAG3"]
    BAG3 -->|"expressed in"| HSPH1
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"expressed in"| HSPH1
    UBC["UBC"]
    UBC -->|"expressed in"| HSPH1
    HSPD1["HSPD1"]
    HSPD1 -->|"expressed in"| HSPH1
    NF__B["NF-KappaB"]
    NF__B -->|"expressed in"| HSPH1
    DNAJC7["DNAJC7"]
    DNAJC7 -->|"expressed in"| HSPH1
    HSPA6["HSPA6"]
    HSPA6 -->|"expressed in"| HSPH1
    DNAJB1["DNAJB1"]
    DNAJB1 -->|"expressed in"| HSPH1
    IKBKB["IKBKB"]
    IKBKB -->|"expressed in"| HSPH1
    HSPA1B["HSPA1B"]
    HSPA1B -->|"expressed in"| HSPH1
    style HSPH1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (25)

TargetRelationTypeStr
Lymphomaexpressed_indisease0.65
Msexpressed_indisease0.65
Cancerexpressed_indisease0.65
Tumorexpressed_indisease0.65
Tumoractivatesdisease0.65

Incoming (31)

SourceRelationTypeStr
UBIQUITINexpressed_ingene0.60
BAG3expressed_ingene0.60
UBCexpressed_ingene0.60
HSPD1expressed_ingene0.60
DNAJC7expressed_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found