gene

LAMB2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LAMB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections

0Hypotheses

0Analyses

14Outgoing

14Incoming

Summary

LAMB2 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, implicated in. Associated with Als, Cancer, Colorectal Cancer. Connected to 29 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	LAMB2
Full Name	Laminin Subunit Beta 2
Chromosome	3p21.31
Function	Integrins: α3β1, α6β1, α7β1 mediate adhesion and signaling
Primary Expression	the peripheral nervous system (PNS) where it plays a role in:
Molecular Weight	210 kDa
Amino Acids	798 aa
Exons	32
Pathways	Mapk
UniProt ID	[P55268](https://www.uniprot.org/uniprot/P55268)
Ensembl ID	ENSG00000172037
OMIM	150325
GeneCards	LAMB2
Human Protein Atlas	LAMB2
Peripheral tissues	Kidney glomerular basement membranes, placental basement membranes, cardiac and skeletal muscle
Associated Diseases	neurodegeneration
Interactions	WNT4, LGALS1, JAK2, GNB4, HSP90B1, EGFR
KG Connections	28 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    LAMB2["LAMB2 (Laminin Beta 2)"]
    
    %% Upstream regulators
    EGFR["EGFR"]
    PI3K["PI3K"]
    IGF1["IGF1"]
    FOXO1["FOXO1"]
    HSP90AA1["HSP90AA1"]
    
    %% Downstream targets - genes
    AXON["AXON"]
    AKT["AKT"]
    JAK2["JAK2"]
    WNT4["WNT4"]
    
    %% Pathways
    Wnt_pathway["Wnt Signaling"]
    MAPK_pathway["MAPK Pathway"]
    
    %% Disease outcomes
    ALS["ALS"]
    Diabetes["Diabetes"]
    Cancer["Cancer"]
    
    %% Connections
    EGFR -->|"activates"| LAMB2
    PI3K -->|"regulates"| LAMB2
    IGF1 -->|"activates"| LAMB2
    FOXO1 -->|"activates"| LAMB2
    HSP90AA1 -->|"activates"| LAMB2
    
    LAMB2 -->|"regulates"| AXON
    LAMB2 -->|"regulates"| AKT
    LAMB2 -->|"activates"| JAK2
    LAMB2 -->|"activates"| WNT4
    
    LAMB2 -->|"activates"| Wnt_pathway
    LAMB2 -->|"regulates"| MAPK_pathway
    
    LAMB2 -->|"activates"| ALS
    LAMB2 -->|"regulates"| Diabetes
    LAMB2 -->|"regulates"| Cancer
    
    %% Styling
    style LAMB2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style EGFR fill:#4a1a6b,stroke:#333,stroke-width:2px
    style PI3K fill:#4a1a6b,stroke:#333,stroke-width:2px
    style IGF1 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style FOXO1 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style HSP90AA1 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style AXON fill:#1b5e20,stroke:#333,stroke-width:2px
    style AKT fill:#4a1a6b,stroke:#333,stroke-width:2px
    style JAK2 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style WNT4 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style Wnt_pathway fill:#1b5e20,stroke:#333,stroke-width:2px
    style MAPK_pathway fill:#1b5e20,stroke:#333,stroke-width:2px
    style ALS fill:#ef5350,stroke:#333,stroke-width:2px
    style Diabetes fill:#7d4200,stroke:#333,stroke-width:2px
    style Cancer fill:#7d4200,stroke:#333,stroke-width:2px

Outgoing (14)

Target	Relation	Type	Str
Melanoma	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Colorectal Cancer	regulates	disease	0.65
Cancer	regulates	disease	0.65
Als	activates	disease	0.65
WNT4	activates	gene	0.60
LGALS1	activates	gene	0.60
JAK2	activates	gene	0.60
AKT	regulates	gene	0.60
GNB4	activates	gene	0.60
AXON	regulates	gene	0.60
CANCER	regulates	gene	0.60
Wnt	activates	pathway	0.60
Mapk	regulates	pathway	0.60

Incoming (14)

Source	Relation	Type	Str
HSP90B1	activates	gene	0.60
PI3K	regulates	gene	0.60
EGFR	activates	gene	0.60
HSPA4	activates	gene	0.60
FOXO1	activates	gene	0.60
HSP90AA1	activates	gene	0.60
PRKACB	activates	gene	0.60
PIK3R1	activates	gene	0.60
IGF1	activates	gene	0.60
CDK1	activates	gene	0.60
QSOX1	activates	gene	0.60
DIABETES MELLITUS	regulates	gene	0.60
GENES	activates	gene	0.60
ERBB2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

LAMB2

Understanding Entity Pages

Summary

Wiki Pages (5)

LAMB2 — Laminin Subunit Beta 2

ALS Regional Onset and Spread: Network-Level Staging Model

QSOX1 Gene