gene

WNT4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WNT4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections

0Hypotheses

0Analyses

12Outgoing

16Incoming

Summary

WNT4 encodes a secreted signaling molecule that activates canonical and non-canonical Wnt pathways, critical for brain development, neuroprotection, and neurodegenerative disease processes.

View on Wiki →

🧬 Gene Info

Gene Symbol	WNT4
Full Name	WNT4
Chromosome	1p36.23
Protein Type	Gene
Function	is a member of the Wnt family of secreted lipid-modified signaling proteins that play critical roles in development, tissue homeostasis, and disease processes.
Primary Expression	various brain regions and regulates neural stem cell maintenance, neuronal differentiation, synapse formation, and neuroprotection
Amino Acids	351 aa
Exons	4
Pathways	WNT, Wnt, Wnt signaling
UniProt ID	P56705
NCBI Gene ID	7498
Ensembl ID	ENSG00000163359
GeneCards	WNT4
Human Protein Atlas	WNT4
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	LGALS1, JAK2, GNB4, HSP90B1, EGFR, HSPA4
KG Connections	28 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: WNT4 — AlphaFold P56705 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    WNT4["WNT4 Gene"]
    
    %% Upstream Regulators
    PI3K["PI3K"]
    FOXO1["FOXO1"]
    EGFR["EGFR"]
    IGF1["IGF1"]
    HSP90AA1["HSP90AA1"]
    
    %% Downstream Targets
    WNT_PATHWAY["Wnt Signaling Pathway"]
    MAPK_PATHWAY["MAPK Pathway"]
    AKT["AKT"]
    JAK2["JAK2"]
    LGALS1["LGALS1"]
    
    %% Disease Connections
    ALS["Amyotrophic Lateral Sclerosis"]
    DIABETES["Diabetes Mellitus"]
    CANCER["Cancer"]
    
    %% Pathway Connections
    PI3K -->|"regulates"| WNT4
    FOXO1 -->|"activates"| WNT4
    EGFR -->|"activates"| WNT4
    IGF1 -->|"activates"| WNT4
    HSP90AA1 -->|"activates"| WNT4
    
    WNT4 -->|"activates"| WNT_PATHWAY
    WNT4 -->|"regulates"| MAPK_PATHWAY
    WNT4 -->|"regulates"| AKT
    WNT4 -->|"activates"| JAK2
    WNT4 -->|"activates"| LGALS1
    
    WNT4 -->|"activates"| ALS
    WNT4 -->|"regulates"| DIABETES
    WNT4 -->|"regulates"| CANCER
    
    %% Styling
    style WNT4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style PI3K fill:#4a1a6b,stroke:#333,stroke-width:2px
    style FOXO1 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style EGFR fill:#4a1a6b,stroke:#333,stroke-width:2px
    style IGF1 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style HSP90AA1 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style WNT_PATHWAY fill:#1b5e20,stroke:#333,stroke-width:2px
    style MAPK_PATHWAY fill:#1b5e20,stroke:#333,stroke-width:2px
    style AKT fill:#1b5e20,stroke:#333,stroke-width:2px
    style JAK2 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style LGALS1 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style ALS fill:#ef5350,stroke:#333,stroke-width:2px
    style DIABETES fill:#7d4200,stroke:#333,stroke-width:2px
    style CANCER fill:#ef5350,stroke:#333,stroke-width:2px

Outgoing (12)

Target	Relation	Type	Str
Melanoma	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Colorectal Cancer	regulates	disease	0.65
Cancer	regulates	disease	0.65
Als	activates	disease	0.65
LGALS1	activates	gene	0.60
JAK2	activates	gene	0.60
AKT	regulates	gene	0.60
GNB4	activates	gene	0.60
CANCER	regulates	gene	0.60
Wnt	activates	pathway	0.60
Mapk	regulates	pathway	0.60

Incoming (16)

Source	Relation	Type	Str
HSP90B1	activates	gene	0.60
PI3K	regulates	gene	0.60
EGFR	activates	gene	0.60
HSPA4	activates	gene	0.60
FOXO1	activates	gene	0.60
HSP90AA1	activates	gene	0.60
PRKACB	activates	gene	0.60
PIK3R1	activates	gene	0.60
IGF1	activates	gene	0.60
CDK1	activates	gene	0.60
QSOX1	activates	gene	0.60
LAMB2	activates	gene	0.60
DIABETES MELLITUS	regulates	gene	0.60
GENES	activates	gene	0.60
ERBB2	activates	gene	0.60
AXON	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found