Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about QSOX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
QSOX1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, implicated in. Associated with Als, Cancer, Colorectal Cancer. Connected to 29 entities in the SciDEX knowledge graph.
| Gene Symbol | QSOX1 |
| Full Name | Quiescin Q6 Sulfhydryl Oxidase 1 |
| Aliases | QSOX, Q6, QSCN6 |
| Chromosome | 1q24.2 |
| Protein Family | Sulfhydryl oxidase, ERV/QUSOX family |
| Protein Type | Enzyme |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | various tissues, with high expression in the brain, particularly in neurons and glial cells[@thorpe2002] |
| Molecular Weight | 67 kDa |
| Amino Acids | 609 aa |
| Pathways | Mapk |
| OMIM | 603180 |
| GeneCards | QSOX1 |
| Human Protein Atlas | QSOX1 |
| Protein | QSOX1 |
| Associated Diseases | neurodegeneration |
| Interactions | LAMB2, WNT4, LGALS1, JAK2, GNB4, HSP90B1 |
| KG Connections | 28 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
QSOX1["QSOX1 (Quiescin Sulfhydryl Oxidase 1)"]
EGFR["EGFR"]
PI3K["PI3K"]
AKT["AKT"]
FOXO1["FOXO1"]
JAK2["JAK2"]
WNT4["WNT4"]
Wnt_pathway["Wnt Signaling Pathway"]
MAPK_pathway["MAPK Pathway"]
HSP90B1["HSP90B1 (Endoplasmic Reticulum Chaperone)"]
LAMB2["LAMB2 (Laminin Beta 2)"]
AXON["Axonal Structure"]
ALS["Amyotrophic Lateral Sclerosis"]
Cancer["Cancer Progression"]
Diabetes["Diabetes Mellitus"]
EGFR -->|"activates"| QSOX1
PI3K -->|"regulates"| QSOX1
FOXO1 -->|"activates"| QSOX1
HSP90B1 -->|"activates"| QSOX1
QSOX1 -->|"regulates"| AKT
QSOX1 -->|"activates"| JAK2
QSOX1 -->|"activates"| WNT4
QSOX1 -->|"activates"| Wnt_pathway
QSOX1 -->|"regulates"| MAPK_pathway
QSOX1 -->|"activates"| LAMB2
QSOX1 -->|"regulates"| AXON
QSOX1 -->|"activates"| ALS
QSOX1 -->|"regulates"| Cancer
QSOX1 -->|"regulates"| Diabetes
style QSOX1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
style LAMB2 fill:#1b5e20,stroke:#4caf50,stroke-width:2px
style AXON fill:#1b5e20,stroke:#4caf50,stroke-width:2px
style EGFR fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
style PI3K fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
style AKT fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
style FOXO1 fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
style JAK2 fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
style WNT4 fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
style HSP90B1 fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
style ALS fill:#ef5350,stroke:#d32f2f,stroke-width:2px
style Cancer fill:#7d4200,stroke:#f57c00,stroke-width:2px
style Diabetes fill:#7d4200,stroke:#f57c00,stroke-width:2px| Target | Relation | Type | Str |
|---|---|---|---|
| Melanoma | regulates | disease | 0.65 |
| Diabetes | regulates | disease | 0.65 |
| Colorectal Cancer | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| LAMB2 | activates | gene | 0.60 |
| WNT4 | activates | gene | 0.60 |
| LGALS1 | activates | gene | 0.60 |
| JAK2 | activates | gene | 0.60 |
| AKT | regulates | gene | 0.60 |
| GNB4 | activates | gene | 0.60 |
| AXON | regulates | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| Wnt | activates | pathway | 0.60 |
| Mapk | regulates | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HSP90B1 | activates | gene | 0.60 |
| PI3K | regulates | gene | 0.60 |
| EGFR | activates | gene | 0.60 |
| HSPA4 | activates | gene | 0.60 |
| FOXO1 | activates | gene | 0.60 |
| HSP90AA1 | activates | gene | 0.60 |
| PRKACB | activates | gene | 0.60 |
| PIK3R1 | activates | gene | 0.60 |
| IGF1 | activates | gene | 0.60 |
| CDK1 | activates | gene | 0.60 |
| DIABETES MELLITUS | regulates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| ERBB2 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||