Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HSPA4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
HSPA4 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, implicated in. Associated with Als, Cancer, Colorectal Cancer. Connected to 40 entities in the SciDEX knowledge graph.
| Gene Symbol | HSPA4 |
| Full Name | Heat Shock Protein Family A (Hsp70) Member 4 |
| Chromosome | 1q22 |
| Protein Type | Chaperone |
| Function | HSPA4 (also known as Hsp70L1 or Apg-2) is a constitutively expressed Hsp70 family member with multiple cellular functions |
| Primary Expression | Inducible by stress, constitutively expressed in some tissues |
| Pathways | NF-κB, MAPK |
| UniProt ID | Q9Y4X5 |
| NCBI Gene ID | 3309 |
| GeneCards | HSPA4 |
| Human Protein Atlas | HSPA4 |
| Protein Class | Hsp70 Family |
| Associated Diseases | neurodegeneration |
| Interactions | FOXO1, HSP90AA1, PRKACB, PIK3R1, IGF1, CDK1 |
| KG Connections | 76 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
HSPA4["<b>HSPA4</b>"]
Neurodegeneration{"Neurodegeneration"}
HSPA4 -->|"regulates"| Neurodegeneration
Multiple_Sclerosis{"Multiple Sclerosis"}
HSPA4 -->|"regulates"| Multiple_Sclerosis
Inflammation{"Inflammation"}
HSPA4 -->|"regulates"| Inflammation
Als{"Als"}
HSPA4 -->|"regulates"| Als
Neuroinflammation{"Neuroinflammation"}
HSPA4 -->|"regulates"| Neuroinflammation
Ms{"Ms"}
HSPA4 -->|"regulates"| Ms
FOXP1["FOXP1"]
HSPA4 -->|"regulates"| FOXP1
DNAJB1["DNAJB1"]
HSPA4 -->|"regulates"| DNAJB1
Oxidative_Stress(["Oxidative Stress"])
HSPA4 -->|"regulates"| Oxidative_Stress
Complement(["Complement"])
HSPA4 -->|"regulates"| Complement
neurodegeneration["neurodegeneration"]
HSPA4 -->|"implicated in"| neurodegeneration
PRKCD["PRKCD"]
PRKCD -->|"associated with"| HSPA4
style HSPA4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Neurodegeneration | regulates | disease | 0.65 |
| Multiple Sclerosis | regulates | disease | 0.65 |
| Inflammation | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Neuroinflammation | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Melanoma | regulates | disease | 0.65 |
| Diabetes | regulates | disease | 0.65 |
| Colorectal Cancer | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| ALS | expressed_in | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| FOXP1 | regulates | gene | 0.60 |
| DNAJB1 | regulates | gene | 0.60 |
| FOXO1 | activates | gene | 0.60 |
| HSP90AA1 | activates | gene | 0.60 |
| PRKACB | activates | gene | 0.60 |
| PIK3R1 | activates | gene | 0.60 |
| IGF1 | activates | gene | 0.60 |
| CDK1 | activates | gene | 0.60 |
| QSOX1 | activates | gene | 0.60 |
| LAMB2 | activates | gene | 0.60 |
| WNT4 | activates | gene | 0.60 |
| LGALS1 | activates | gene | 0.60 |
| JAK2 | activates | gene | 0.60 |
| AKT | regulates | gene | 0.60 |
| GNB4 | activates | gene | 0.60 |
| NFKBIA | expressed_in | gene | 0.60 |
| ENO1 | expressed_in | gene | 0.60 |
| RHOA | expressed_in | gene | 0.60 |
| CYCS | expressed_in | gene | 0.60 |
| ITGAM | expressed_in | gene | 0.60 |
| PPARG | expressed_in | gene | 0.60 |
| RELA | expressed_in | gene | 0.60 |
| SOD1 | expressed_in | gene | 0.60 |
| TP53 | expressed_in | gene | 0.60 |
| VDAC1 | expressed_in | gene | 0.60 |
| YWHAZ | expressed_in | gene | 0.60 |
| SIRT1 | interacts_with | gene | 0.60 |
| SIRT1 | associated_with | gene | 0.60 |
| neuroinflammation | interacts_with | disease | 0.60 |
| Oxidative Stress | regulates | pathway | 0.60 |
| Complement | regulates | pathway | 0.60 |
| DIABETES MELLITUS | regulates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| ERBB2 | activates | gene | 0.60 |
| AXON | regulates | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| Wnt | activates | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PRKCD | associated_with | gene | 0.80 |
| HSP90B1 | activates | gene | 0.60 |
| PI3K | regulates | gene | 0.60 |
| EGFR | activates | gene | 0.60 |
| YWHAZ | expressed_in | gene | 0.60 |
| HSP90AB1 | expressed_in | gene | 0.60 |
| CAV1 | expressed_in | gene | 0.60 |
| VDAC1 | expressed_in | gene | 0.60 |
| PI3K | expressed_in | gene | 0.60 |
| SOD1 | expressed_in | gene | 0.60 |
| RELA | expressed_in | gene | 0.60 |
| ITGAM | expressed_in | gene | 0.60 |
| PPARG | expressed_in | gene | 0.60 |
| TP53 | expressed_in | gene | 0.60 |
| AKT | expressed_in | gene | 0.60 |
| CYCS | expressed_in | gene | 0.60 |
| ENO1 | expressed_in | gene | 0.60 |
| ANXA5 | expressed_in | gene | 0.60 |
| CCND1 | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||