gene

HSPA4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSPA4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

76Connections
0Hypotheses
0Analyses
50Outgoing
19Incoming

Summary

HSPA4 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, implicated in. Associated with Als, Cancer, Colorectal Cancer. Connected to 40 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolHSPA4
Full NameHeat Shock Protein Family A (Hsp70) Member 4
Chromosome1q22
Protein TypeChaperone
FunctionHSPA4 (also known as Hsp70L1 or Apg-2) is a constitutively expressed Hsp70 family member with multiple cellular functions
Primary ExpressionInducible by stress, constitutively expressed in some tissues
PathwaysNF-κB, MAPK
UniProt IDQ9Y4X5
NCBI Gene ID3309
GeneCardsHSPA4
Human Protein AtlasHSPA4
Protein ClassHsp70 Family
Associated Diseasesneurodegeneration
InteractionsFOXO1, HSP90AA1, PRKACB, PIK3R1, IGF1, CDK1
KG Connections76 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: HSPA4 — AlphaFold Q9Y4X5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (15)

Knowledge base pages for this entity

Canonical Page

HSPA4 Gene

gene · 652 words

cbs-psp-daily-action-plan

therapeutic · 30834 words

DNAJB5 (DnaJ Heat Shock Protein Family Member B5)

gene · 2425 words

Heat Shock Proteins

protein · 1421 words

DNAJB1 Gene

gene · 1299 words

Heat Shock Protein 70 (HSPA1A)

protein · 1177 words

Pathway Diagram

graph TD
    HSPA4["<b>HSPA4</b>"]
    Neurodegeneration{"Neurodegeneration"}
    HSPA4 -->|"regulates"| Neurodegeneration
    Multiple_Sclerosis{"Multiple Sclerosis"}
    HSPA4 -->|"regulates"| Multiple_Sclerosis
    Inflammation{"Inflammation"}
    HSPA4 -->|"regulates"| Inflammation
    Als{"Als"}
    HSPA4 -->|"regulates"| Als
    Neuroinflammation{"Neuroinflammation"}
    HSPA4 -->|"regulates"| Neuroinflammation
    Ms{"Ms"}
    HSPA4 -->|"regulates"| Ms
    FOXP1["FOXP1"]
    HSPA4 -->|"regulates"| FOXP1
    DNAJB1["DNAJB1"]
    HSPA4 -->|"regulates"| DNAJB1
    Oxidative_Stress(["Oxidative Stress"])
    HSPA4 -->|"regulates"| Oxidative_Stress
    Complement(["Complement"])
    HSPA4 -->|"regulates"| Complement
    neurodegeneration["neurodegeneration"]
    HSPA4 -->|"implicated in"| neurodegeneration
    PRKCD["PRKCD"]
    PRKCD -->|"associated with"| HSPA4
    style HSPA4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (57)

TargetRelationTypeStr
Neurodegenerationregulatesdisease0.65
Multiple Sclerosisregulatesdisease0.65
Inflammationregulatesdisease0.65
Alsregulatesdisease0.65
Neuroinflammationregulatesdisease0.65

Incoming (19)

SourceRelationTypeStr
PRKCDassociated_withgene0.80
HSP90B1activatesgene0.60
PI3Kregulatesgene0.60
EGFRactivatesgene0.60
YWHAZexpressed_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found