protein

PRKACB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRKACB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

56Connections

0Hypotheses

0Analyses

37Outgoing

19Incoming

Summary

Protein Kinase A Catalytic Subunit Beta — cAMP-dependent serine/threonine kinase involved in neuronal signaling, synaptic plasticity, and memory formation

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🔬 Protein Info

Gene Symbol	PRKACB
Full Name	Protein Kinase cAMP-Activated Catalytic Subunit Beta
Chromosome	1p31.1
Function	PKA catalytic subunit β (PKA-Cβ) catalyzes phosphate transfer: - cAMP binds to regulatory subunits, releasing catalytic subunits - Free catalytic subunits phosphorylate target proteins on serine/threo
Molecular Weight	40.6 kDa
Amino Acids	361 aa
Pathways	Mapk
UniProt ID	P22694
Ensembl ID	ENSG00000142831
GeneCards	PRKACB
Human Protein Atlas	PRKACB
Synaptic plasticity	Phosphorylation of AMPA receptor subunits
Gene transcription	CREB phosphorylation and activation
Ion channel modulation	Regulation of NMDA, AMPA, and voltage-gated channels
Cytoskeletal dynamics	Microtubule-associated proteins
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	PIK3R1, IGF1, CDK1, QSOX1, LAMB2, WNT4
KG Connections	56 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PRKACB — AlphaFold P22694 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PRKACB["PRKACB (PKA Catalytic Subunit beta)"]
    
    %% Upstream regulators
    EGFR["EGFR"]
    PI3K["PI3K"]
    HSP90B1["HSP90B1"]
    FOXO1["FOXO1"]
    
    %% Downstream targets - signaling
    AKT["AKT"]
    IGF1["IGF1"]
    JAK2["JAK2"]
    CDK1["CDK1"]
    
    %% Pathways
    WNT["Wnt Signaling"]
    MAPK["MAPK Pathway"]
    
    %% Neurodegeneration context
    ALS["Amyotrophic Lateral Sclerosis"]
    AXON["Axon Regulation"]
    
    %% Cancer context
    CANCER["Cancer Pathways"]
    
    %% Connections
    EGFR -->|"activates"| PRKACB
    PI3K -->|"regulates"| PRKACB
    HSP90B1 -->|"activates"| PRKACB
    FOXO1 -->|"activates"| PRKACB
    
    PRKACB -->|"regulates"| AKT
    PRKACB -->|"activates"| IGF1
    PRKACB -->|"activates"| JAK2
    PRKACB -->|"activates"| CDK1
    
    PRKACB -->|"activates"| WNT
    PRKACB -->|"regulates"| MAPK
    
    PRKACB -->|"activates"| ALS
    PRKACB -->|"regulates"| AXON
    PRKACB -->|"regulates"| CANCER
    
    %% Styling
    style PRKACB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style IGF1 fill:#1b5e20,stroke:#4caf50,stroke-width:2px
    style AXON fill:#1b5e20,stroke:#4caf50,stroke-width:2px
    style ALS fill:#ef5350,stroke:#d32f2f,stroke-width:2px
    style CANCER fill:#ef5350,stroke:#d32f2f,stroke-width:2px
    style EGFR fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
    style PI3K fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
    style AKT fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
    style FOXO1 fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
    style WNT fill:#7d4200,stroke:#ff9800,stroke-width:2px
    style MAPK fill:#7d4200,stroke:#ff9800,stroke-width:2px

Outgoing (37)

Target	Relation	Type	Str
Melanoma	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Colorectal Cancer	regulates	disease	0.65
Cancer	regulates	disease	0.65
Als	activates	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
Stroke	activates	disease	0.65
Ischemia	activates	disease	0.65
PIK3R1	activates	gene	0.60
IGF1	activates	gene	0.60
CDK1	activates	gene	0.60
QSOX1	activates	gene	0.60
LAMB2	activates	gene	0.60
WNT4	activates	gene	0.60
LGALS1	activates	gene	0.60
JAK2	activates	gene	0.60
AKT	regulates	gene	0.60
GNB4	activates	gene	0.60
PSD95	expressed_in	gene	0.60
SYT1	expressed_in	gene	0.60
ERBB2	activates	gene	0.60
AXON	regulates	gene	0.60
CANCER	regulates	gene	0.60
Wnt	activates	pathway	0.60
Mapk	regulates	pathway	0.60
Synaptic Plasticity	expressed_in	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
Neuron	therapeutic_target	cell_type	0.60
Bdnf	expressed_in	protein	0.60
oxidative stress response	participates_in	pathway	0.60
Apoptosis	activates	pathway	0.60
Cortex	expressed_in	brain_region	0.55
Hippocampus	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55

Incoming (19)

Source	Relation	Type	Str
HSP90B1	activates	gene	0.60
PI3K	regulates	gene	0.60
EGFR	activates	gene	0.60
HSPA4	activates	gene	0.60
FOXO1	activates	gene	0.60
HSP90AA1	activates	gene	0.60
SYT1	expressed_in	gene	0.60
BDNF	expressed_in	gene	0.60
SHANK2	expressed_in	gene	0.60
SYN1	expressed_in	gene	0.60
PSD95	expressed_in	gene	0.60
BAX	expressed_in	gene	0.60
CREB1	expressed_in	gene	0.60
DIABETES MELLITUS	regulates	gene	0.60
GENES	activates	gene	0.60
STROKE	therapeutic_target	gene	0.60
BCL-2	expressed_in	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
PKA	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PRKACB

Understanding Entity Pages

Summary

Wiki Pages (8)

PRKACB — Protein Kinase cAMP-Activated Catalytic Subunit Beta

PRKACB Protein

PRKAR1B — Protein Kinase A Regulatory Subunit 1 Beta

PRKAR1A - Protein Kinase A Regulatory Subunit 1 Alpha

SHANK2 Gene

PRKACG — Protein Kinase A Catalytic Subunit Gamma