LETM1

Understanding Entity Pages

This page aggregates everything SciDEX knows about LETM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

LETM1 is a mitochondrial inner membrane protein that functions as a calcium/proton antiporter, essential for mitochondrial morphology, cristae structure, and implicated in neurodegeneration

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graph TD
    LETM1["<b>LETM1</b>"]
    Cancer{"Cancer"}
    LETM1 -->|"therapeutic target"| Cancer
    Neurodegeneration{"Neurodegeneration"}
    LETM1 -->|"therapeutic target"| Neurodegeneration
    Stroke{"Stroke"}
    LETM1 -->|"therapeutic target"| Stroke
    Ms{"Ms"}
    LETM1 -->|"therapeutic target"| Ms
    Heart_Failure{"Heart Failure"}
    LETM1 -->|"therapeutic target"| Heart_Failure
    Diabetes{"Diabetes"}
    LETM1 -->|"therapeutic target"| Diabetes
    LETM1 -->|"associated with"| Cancer
    LETM1 -->|"associated with"| Diabetes
    LETM1 -->|"associated with"| Heart_Failure
    LETM1 -->|"associated with"| Neurodegeneration
    LETM1 -->|"associated with"| Stroke
    LETM1 -->|"regulates"| Heart_Failure
    OVERVIEW["OVERVIEW"]
    OVERVIEW -->|"regulates"| LETM1
    MCU["MCU"]
    MCU -->|"regulates"| LETM1
    STROKE["STROKE"]
    STROKE -->|"regulates"| LETM1
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"regulates"| LETM1
    CANCER["CANCER"]
    CANCER -->|"regulates"| LETM1
    style LETM1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0