disease

Heart Failure

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Heart Failure: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

887Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Heart Failure is a disease characterized by neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with Aging, Als, Alzheimer. Connected to 655 entities in the SciDEX knowledge graph.

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Disease Info

Associated Genes	LRP8, LRP5, LRP1, LRP2, LRP1B, LRP4, LDLR, GAIN
Therapeutic Agents	Gliflozins, Tirzepatide
KG Connections	832 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Heart_Failure["Heart Failure"] -->|"therapeutic target"| Immune_Response["Immune Response"]
    Heart_Failure["Heart Failure"] -->|"therapeutic target"| Epigenetic["Epigenetic"]
    Heart_Failure["Heart Failure"] -->|"activates"| Epigenetic_1["Epigenetic"]
    Heart_Failure["Heart Failure"] -->|"associated"| Lipid_Metabolism["Lipid Metabolism"]
    Heart_Failure["Heart Failure"] -->|"associated"| Wnt["Wnt"]
    Heart_Failure["Heart Failure"] -.->|"inhibits"| Apoptosis["Apoptosis"]
    LETM1["LETM1"] -->|"therapeutic target"| Heart_Failure["Heart Failure"]
    MCU["MCU"] -->|"therapeutic target"| Heart_Failure["Heart Failure"]
    OVERVIEW["OVERVIEW"] -->|"therapeutic target"| Heart_Failure["Heart Failure"]
    ASXL1["ASXL1"] -->|"therapeutic target"| Heart_Failure["Heart Failure"]
    style Heart_Failure fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (266)

Target	Relation	Type	Str
Oxidative Stress	activates	pathway	1.00
Cardiac	therapeutic_target	disease	0.95
Stroke	associated_with	disease	0.95
Vascular Remodelling	associated_with	process	0.90
Cardiac	inhibits	disease	0.85
Cardiac	activates	disease	0.85
Fibrosis	activates	disease	0.85
Atherosclerosis	associated_with	disease	0.85
Mitophagy	activates	pathway	0.80
Apoptosis	regulates	pathway	0.80
Mitochondrial Function	therapeutic_target	pathway	0.80
Oxidative Stress	regulates	pathway	0.80
Apoptosis	activates	pathway	0.75
Inflammation	regulates	disease	0.75
Inflammation	activates	disease	0.75
Atherosclerosis	implicated_in	disease	0.75
Obesity	associated_with	disease	0.75
Cardiac	causes	disease	0.75
Inflammation	associated_with	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Epigenetic	therapeutic_target	pathway	0.70
Oxidative Stress	contributes_to	pathway	0.70
Epigenetic	contributes_to	pathway	0.70
Ferroptosis	activates	pathway	0.70
Nf-Κb	inhibits	pathway	0.70
Stem Cell	activates	pathway	0.70
Mitophagy	therapeutic_target	pathway	0.70
Stem Cell	therapeutic_target	pathway	0.70
Oxidative Stress	associated_with	pathway	0.70
Stem Cell	implicated_in	pathway	0.70
Oxidative Stress	therapeutic_target	pathway	0.70
Apoptosis	therapeutic_target	pathway	0.70
Lipid Metabolism	activates	pathway	0.70
Senescence	associated_with	pathway	0.70
Autophagy	inhibits	pathway	0.65
Oxidative Stress	inhibits	pathway	0.65
Type 2 Diabetes	inhibits	disease	0.65
Cardiovascular	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Cardiac	contributes_to	disease	0.65
Als	regulates	disease	0.65
Cardiac	associated_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Cardiac	regulates	disease	0.65
Als	associated_with	disease	0.65
Inflammation	contributes_to	disease	0.65
Arrhythmia	associated_with	disease	0.65
Stroke	activates	disease	0.65
Type 2 Diabetes	activates	disease	0.65
Ischemia	therapeutic_target	disease	0.65

Incoming (621)

Source	Relation	Type	Str
Cardiovascular	associated_with	disease	1.00
Hypertension	associated_with	disease	1.00
OXIDATIVE STRESS	activates	gene	1.00
STROKE	associated_with	gene	1.00
AGING	associated_with	gene	1.00
Als	activates	disease	1.00
Aging	associated_with	disease	1.00
Als	therapeutic_target	disease	1.00
Cardiovascular	activates	disease	1.00
Cardiovascular	therapeutic_target	disease	1.00
Coronary Artery Disease	associated_with	disease	1.00
OXIDATIVE STRESS	regulates	gene	0.95
CANCER	associated_with	gene	0.95
INFLAMMATION	regulates	gene	0.95
APOPTOSIS	regulates	gene	0.95
MITOPHAGY	activates	gene	0.95
INFLAMMATION	activates	gene	0.95
Cardiac Aging	contributes_to	process	0.95
MITOCHONDRIA	therapeutic_target	gene	0.95
Cardiac	activates	disease	0.95
Hypertension	activates	disease	0.95
Diabetes	activates	disease	0.95
Gliflozins	treats	drug	0.95
Mitochondrial Calcium Exchange	associated_with	process	0.90
Chronic Inflammation	involved_in	process	0.90
Type 2 Diabetes	risk_factor_for	disease	0.90
Mitochondrial Calcium Transport	contributes_to	process	0.90
OVERVIEW	therapeutic_target	gene	0.85
Diabetes	associated_with	disease	0.85
Cancer	associated_with	disease	0.85
STAT3	activates	gene	0.85
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	0.85
DIABETES MELLITUS	activates	gene	0.85
OVERVIEW	regulates	gene	0.85
STROKE	activates	gene	0.85
INFLAMMATION	contributes_to	gene	0.85
Clonal Hematopoiesis	contributes_to	process	0.85
Cellular Senescence	involved_in	process	0.85
Cardiac	therapeutic_target	disease	0.85
Cardiovascular	regulates	disease	0.85
GENES	implicated_in	gene	0.85
GENES	associated_with	gene	0.85
INFLAMMATION	associated_with	gene	0.85
Cardiac	regulates	disease	0.85
INFLAMMATION	therapeutic_target	gene	0.85
Clonal Hematopoiesis	associated_with	process	0.85
Selective Autophagy Dysfunction	contributes_to	phenotype	0.85
Atherosclerosis	causes	disease	0.85
Macrophage	associated_with	cell_type	0.85
aberrant mitochondrial calcium homeostasis	contributes_to	phenotype	0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Heart Failure

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

CBS/PSP Supplements Guide

williams-syndrome

Mitochondrial Dysfunction in Parkinson's Disease

Mitochondrial Dysfunction in Neurodegeneration

COX20 Gene - Cytochrome c Oxidase Assembly Factor

Calcium Dysregulation in Neurodegeneration

JPH2 — Junctophilin 2

gladstone

Mitochondrial Support Strategies for CBS/PSP

FGF23 — Fibroblast Growth Factor 23

PNMT Protein

Lupin Pharmaceuticals

Friedreich's Ataxia

NIH Drug Repurposing Program for Neurodegenerative Diseases

Amiloride

SCO1 — Cytochrome c Oxidase Assembly Factor SCO1

Utilisation of Health Services and Quality of Life in Atypical Parkinsonian Syndromes (NCT06645626)