Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LRRN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | LRRN1 |
| Full Name | Leucine Rich Repeat Neuronal 1 |
| Chromosome | 5p15.2 |
| Protein Family | Leucine-rich repeat (LRR) proteins |
| Protein Type | Receptor |
| Function | encodes a transmembrane receptor protein belonging to the leucine-rich repeat (LRR) family. |
| Primary Expression | the central nervous system, particularly in regions rich in dopaminergic neurons, where it plays critical roles in neuronal development, synaptic form |
| Amino Acids | 662 aa |
| UniProt ID | [Q9UHV9](https://www.uniprot.org/uniprot/Q9UHV9) |
| Ensembl ID | ENSG00000171208 |
| GeneCards | LRRN1 |
| Human Protein Atlas | LRRN1 |
| Chromosomal location | 5p15.2 |
| Exon count | Multiple exons spanning approximately 20kb |
| Promoter region | Contains neuronal-specific regulatory elements |
| Associated Diseases | Graves' Disease |
| KG Connections | 33 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
LRRN1["<b>LRRN1</b>"]
Gastric_Cancer["Gastric Cancer"]
LRRN1 -->|"upregulates"| Gastric_Cancer
Fas_FasL_Pathway["Fas/FasL Pathway"]
LRRN1 -->|"inhibits"| Fas_FasL_Pathway
Graves__Disease["Graves' Disease"]
LRRN1 -->|"associated with"| Graves__Disease
Als["Als"]
LRRN1 -->|"regulates"| Als
Cancer["Cancer"]
LRRN1 -->|"regulates"| Cancer
ALS["ALS"]
LRRN1 -->|"regulates"| ALS
ERK1["ERK1"]
LRRN1 -->|"regulates"| ERK1
PI3K["PI3K"]
LRRN1 -->|"regulates"| PI3K
NEURON["NEURON"]
LRRN1 -->|"regulates"| NEURON
SMPD1["SMPD1"]
LRRN1 -->|"regulates"| SMPD1
PKC["PKC"]
LRRN1 -->|"regulates"| PKC
EPHA8["EPHA8"]
LRRN1 -->|"regulates"| EPHA8
P38["P38"]
LRRN1 -->|"regulates"| P38
GSK3["GSK3"]
LRRN1 -->|"regulates"| GSK3
Neuron["Neuron"]
LRRN1 -->|"regulates"| Neuron
SMPD1["SMPD1"]
SMPD1 -->|"regulates"| LRRN1
PKC["PKC"]
PKC -->|"regulates"| LRRN1
GAIN["GAIN"]
GAIN -->|"regulates"| LRRN1
EPHA8["EPHA8"]
EPHA8 -->|"regulates"| LRRN1
GSK3["GSK3"]
GSK3 -->|"regulates"| LRRN1
AND["AND"]
AND -->|"regulates"| LRRN1
NEURON["NEURON"]
NEURON -->|"regulates"| LRRN1
P38["P38"]
P38 -->|"regulates"| LRRN1
CANCER["CANCER"]
CANCER -->|"regulates"| LRRN1
PI3K["PI3K"]
PI3K -->|"regulates"| LRRN1
ERK1["ERK1"]
ERK1 -->|"regulates"| LRRN1
Neuron["Neuron"]
LRRN1 -->|"expressed in"| Neuron
neurodegeneration["neurodegeneration"]
LRRN1 -->|"implicated in"| neurodegeneration| Target | Relation | Type | Str |
|---|---|---|---|
| Fas/FasL Pathway | inhibits | pathway | 0.80 |
| Gastric Cancer | upregulates | disease | 0.80 |
| Graves' Disease | associated_with | disease | 0.70 |
| Als | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| ERK1 | regulates | gene | 0.60 |
| PI3K | regulates | gene | 0.60 |
| SMPD1 | regulates | gene | 0.60 |
| PKC | regulates | gene | 0.60 |
| EPHA8 | regulates | gene | 0.60 |
| P38 | regulates | gene | 0.60 |
| NEURON | regulates | gene | 0.60 |
| GSK3 | regulates | gene | 0.60 |
| Neuron | regulates | cell_type | 0.60 |
| Interferon | regulates | protein | 0.60 |
| Cytokine | regulates | protein | 0.60 |
| Erk | regulates | protein | 0.60 |
| Fgf | regulates | protein | 0.60 |
| Ras | regulates | protein | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||