gene

LRRN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LRRN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections
0Hypotheses
0Analyses
22Outgoing
11Incoming

No summary available yet. View on Wiki →

🧬 Gene Info
Gene SymbolLRRN1
Full NameLeucine Rich Repeat Neuronal 1
Chromosome5p15.2
Protein FamilyLeucine-rich repeat (LRR) proteins
Protein TypeReceptor
Functionencodes a transmembrane receptor protein belonging to the leucine-rich repeat (LRR) family.
Primary Expressionthe central nervous system, particularly in regions rich in dopaminergic neurons, where it plays critical roles in neuronal development, synaptic form
Amino Acids662 aa
UniProt ID[Q9UHV9](https://www.uniprot.org/uniprot/Q9UHV9)
Ensembl IDENSG00000171208
GeneCardsLRRN1
Human Protein AtlasLRRN1
Chromosomal location5p15.2
Exon countMultiple exons spanning approximately 20kb
Promoter regionContains neuronal-specific regulatory elements
Associated DiseasesGraves' Disease
KG Connections33 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

LRRN1 — Leucine Rich Repeat Neuronal 1

gene · 1696 words

AHEAD 3-45 Study: A Placebo-Controlled, Double-Blind, Parallel-Treatment Arm,... (NCT04468659)

clinical · 1296 words

Pathway Diagram

graph TD
    LRRN1["<b>LRRN1</b>"]
    Gastric_Cancer["Gastric Cancer"]
    LRRN1 -->|"upregulates"| Gastric_Cancer
    Fas_FasL_Pathway["Fas/FasL Pathway"]
    LRRN1 -->|"inhibits"| Fas_FasL_Pathway
    Graves__Disease["Graves' Disease"]
    LRRN1 -->|"associated with"| Graves__Disease
    Als["Als"]
    LRRN1 -->|"regulates"| Als
    Cancer["Cancer"]
    LRRN1 -->|"regulates"| Cancer
    ALS["ALS"]
    LRRN1 -->|"regulates"| ALS
    ERK1["ERK1"]
    LRRN1 -->|"regulates"| ERK1
    PI3K["PI3K"]
    LRRN1 -->|"regulates"| PI3K
    NEURON["NEURON"]
    LRRN1 -->|"regulates"| NEURON
    SMPD1["SMPD1"]
    LRRN1 -->|"regulates"| SMPD1
    PKC["PKC"]
    LRRN1 -->|"regulates"| PKC
    EPHA8["EPHA8"]
    LRRN1 -->|"regulates"| EPHA8
    P38["P38"]
    LRRN1 -->|"regulates"| P38
    GSK3["GSK3"]
    LRRN1 -->|"regulates"| GSK3
    Neuron["Neuron"]
    LRRN1 -->|"regulates"| Neuron
    SMPD1["SMPD1"]
    SMPD1 -->|"regulates"| LRRN1
    PKC["PKC"]
    PKC -->|"regulates"| LRRN1
    GAIN["GAIN"]
    GAIN -->|"regulates"| LRRN1
    EPHA8["EPHA8"]
    EPHA8 -->|"regulates"| LRRN1
    GSK3["GSK3"]
    GSK3 -->|"regulates"| LRRN1
    AND["AND"]
    AND -->|"regulates"| LRRN1
    NEURON["NEURON"]
    NEURON -->|"regulates"| LRRN1
    P38["P38"]
    P38 -->|"regulates"| LRRN1
    CANCER["CANCER"]
    CANCER -->|"regulates"| LRRN1
    PI3K["PI3K"]
    PI3K -->|"regulates"| LRRN1
    ERK1["ERK1"]
    ERK1 -->|"regulates"| LRRN1
    Neuron["Neuron"]
    LRRN1 -->|"expressed in"| Neuron
    neurodegeneration["neurodegeneration"]
    LRRN1 -->|"implicated in"| neurodegeneration

Outgoing (22)

TargetRelationTypeStr
Fas/FasL Pathwayinhibitspathway0.80
Gastric Cancerupregulatesdisease0.80
Graves' Diseaseassociated_withdisease0.70
Alsregulatesdisease0.65
Cancerregulatesdisease0.65

Incoming (11)

SourceRelationTypeStr
SMPD1regulatesgene0.60
PKCregulatesgene0.60
GAINregulatesgene0.60
EPHA8regulatesgene0.60
P38regulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found