Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EPHA8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Ephrin Type-A Receptor 8, a receptor tyrosine kinase involved in neuronal development, axon guidance, and cognitive function
| Gene Symbol | EPHA8 |
| Full Name | Ephrin Type-A Receptor 8 |
| Chromosome | 1p36.22 |
| Protein Type | Receptor |
| Function | Hippocampal Function: EPHA8 is highly expressed in CA1 pyramidal neurons where it regulates synaptic plasticity and spatial memory formation[@li2019]. |
| Primary Expression | Pyramidal neurons, Interneurons, Glia |
| Molecular Weight | 105 kDa |
| Amino Acids | 986 aa |
| Exons | 18 |
| UniProt ID | Q9Y232 |
| NCBI Gene ID | 2045 |
| Ensembl ID | ENSG00000077312 |
| OMIM | 603306 |
| GeneCards | EPHA8 |
| Human Protein Atlas | EPHA8 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
EPHA8["<b>EPHA8</b>"]
Als{"Als"}
EPHA8 -->|"regulates"| Als
Cancer{"Cancer"}
EPHA8 -->|"regulates"| Cancer
ALS{"ALS"}
EPHA8 -->|"regulates"| ALS
P38(["P38"])
EPHA8 -->|"associated_with"| P38
GSK3(["GSK3"])
EPHA8 -->|"associated_with"| GSK3
Neuron["Neuron"]
EPHA8 -->|"regulates"| Neuron
LRRN1(["LRRN1"])
LRRN1 -->|"regulates"| EPHA8
ERK1(["ERK1"])
ERK1 -->|"associated_with"| EPHA8
PI3K(["PI3K"])
PI3K -->|"associated_with"| EPHA8
NEURON(["NEURON"])
NEURON -->|"regulates"| EPHA8
style EPHA8 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8| Target | Relation | Type | Str |
|---|---|---|---|
| Als | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| P38 | associated_with | gene | 0.60 |
| PI3K | associated_with | gene | 0.60 |
| ERK1 | associated_with | gene | 0.60 |
| LRRN1 | regulates | gene | 0.60 |
| SMPD1 | regulates | gene | 0.60 |
| GSK3 | associated_with | gene | 0.60 |
| Neuron | regulates | cell_type | 0.60 |
| AND | associated_with | gene | 0.60 |
| NEURON | regulates | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| Interferon | regulates | protein | 0.60 |
| Cytokine | regulates | protein | 0.60 |
| Erk | associated_with | protein | 0.60 |
| Fgf | associated_with | protein | 0.60 |
| Ras | regulates | protein | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
| Proteins | associated_with | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||